14 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BMP7	Bone morphogenetic protein 7. (431 aa)
	SIX4	SIX homeobox 4. (781 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	STAT1	Signal transducer and activator of transcription. (758 aa)
	PDGFRB	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
	WT1	WT1 transcription factor. (514 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	BASP1	Brain abundant, membrane attached signal protein 1. (226 aa)
	SIX1	SIX homeobox 1. (284 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
	PAX2	PAX2 isoform 1. (417 aa)
	TCF21	Transcription factor 21. (179 aa)
	OSR1	Odd-skipped related transcription factor 1. (266 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (968 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BASP1	WT1	ENSPTRP00000067678	ENSPTRP00000087673	Brain abundant, membrane attached signal protein 1.	WT1 transcription factor.	0.615
BMP7	PAX2	ENSPTRP00000023489	ENSPTRP00000091068	Bone morphogenetic protein 7.	PAX2 isoform 1.	0.457
BMP7	SHH	ENSPTRP00000023489	ENSPTRP00000075730	Bone morphogenetic protein 7.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.648
BMP7	SMAD4	ENSPTRP00000023489	ENSPTRP00000017047	Bone morphogenetic protein 7.	Mothers against decapentaplegic homolog.	0.699
BMP7	WNT4	ENSPTRP00000023489	ENSPTRP00000063328	Bone morphogenetic protein 7.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.411
PAX2	BMP7	ENSPTRP00000091068	ENSPTRP00000023489	PAX2 isoform 1.	Bone morphogenetic protein 7.	0.457
PAX2	SHH	ENSPTRP00000091068	ENSPTRP00000075730	PAX2 isoform 1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.479
PAX2	SIX1	ENSPTRP00000091068	ENSPTRP00000070117	PAX2 isoform 1.	SIX homeobox 1.	0.681
PAX2	WNT4	ENSPTRP00000091068	ENSPTRP00000063328	PAX2 isoform 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.472
PAX2	WT1	ENSPTRP00000091068	ENSPTRP00000087673	PAX2 isoform 1.	WT1 transcription factor.	0.666
PDGFRB	STAT1	ENSPTRP00000080188	ENSPTRP00000090934	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.	Signal transducer and activator of transcription.	0.568
SHH	BMP7	ENSPTRP00000075730	ENSPTRP00000023489	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Bone morphogenetic protein 7.	0.648
SHH	PAX2	ENSPTRP00000075730	ENSPTRP00000091068	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	PAX2 isoform 1.	0.479
SHH	WNT4	ENSPTRP00000075730	ENSPTRP00000063328	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.400
SIX1	PAX2	ENSPTRP00000070117	ENSPTRP00000091068	SIX homeobox 1.	PAX2 isoform 1.	0.681
SIX1	SIX4	ENSPTRP00000070117	ENSPTRP00000044052	SIX homeobox 1.	SIX homeobox 4.	0.485
SIX4	SIX1	ENSPTRP00000044052	ENSPTRP00000070117	SIX homeobox 4.	SIX homeobox 1.	0.485
SMAD4	BMP7	ENSPTRP00000017047	ENSPTRP00000023489	Mothers against decapentaplegic homolog.	Bone morphogenetic protein 7.	0.699
STAT1	PDGFRB	ENSPTRP00000090934	ENSPTRP00000080188	Signal transducer and activator of transcription.	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.	0.568
TCF21	WT1	ENSPTRP00000031786	ENSPTRP00000087673	Transcription factor 21.	WT1 transcription factor.	0.510