STRINGSTRING
ENSPTRP00000069764 ENSPTRP00000069764 SIX1 SIX1 POU3F3 POU3F3 FGF8 FGF8 SHH SHH ENSPTRP00000075757 ENSPTRP00000075757 ENSPTRP00000075771 ENSPTRP00000075771 NOTCH2 NOTCH2 WNT9B-2 WNT9B-2 UMOD UMOD ENSPTRP00000077262 ENSPTRP00000077262 TFAP2B TFAP2B HS2ST1 HS2ST1 CTNNBIP1 CTNNBIP1 TACSTD2 TACSTD2 LGR4 LGR4 FOXD1 FOXD1 PAX2 PAX2 MEF2C MEF2C BCL2 BCL2 LAMA5 LAMA5 HEYL HEYL DCHS1 DCHS1 WT1 WT1 PTCH1 PTCH1 HS3ST3A1 HS3ST3A1 NPNT NPNT PAX8 PAX8 CK820_G0054628 CK820_G0054628 MTSS1 MTSS1 LZTS2 LZTS2 HNF1B HNF1B BMP4-2 BMP4-2 HES5-2 HES5-2 WNT6 WNT6 WNT11 WNT11 AQP11 AQP11 ACAT1 ACAT1 WNT1 WNT1 BMP4 BMP4 SOX8 SOX8 IRX3 IRX3 WNK4 WNK4 NOG NOG SOX9 SOX9 GREB1 GREB1 SMAD4 SMAD4 TMEM59L TMEM59L OSR1 OSR1 BMP2 BMP2 JAG1 JAG1 GZF1 GZF1 PKD2 PKD2 IRX2 IRX2 IRX1 IRX1 ADAMTS16 ADAMTS16 KLHL3 KLHL3 FGF1 FGF1 TCF21 TCF21 AHI1 AHI1 DLL1 DLL1 HOXA11 HOXA11 AQP1 AQP1 GLI3 GLI3 EYA1 EYA1 CALB1 CALB1 COMMD5 COMMD5 NOTCH1 NOTCH1 CITED1 CITED1 HES5 HES5 HS3ST3B1 HS3ST3B1 CTNNB1 CTNNB1 GDNF GDNF KIF26B KIF26B LHX1 LHX1 HOXD11 HOXD11 PGF PGF WNT9B WNT9B PBX1 PBX1 WNT4 WNT4 WNT7B WNT7B FMN1 FMN1 HES1 HES1 SALL1 SALL1 GATA3 GATA3 CK820_G0056924 CK820_G0056924 ILK ILK DLG1 DLG1 FGF2 FGF2 GPC3 GPC3 GREB1L GREB1L
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSPTRP00000069764annotation not available (1213 aa)
SIX1SIX homeobox 1. (284 aa)
POU3F3POU domain protein. (476 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
ENSPTRP00000075757annotation not available (495 aa)
ENSPTRP00000075771COMM domain-containing protein 5. (229 aa)
NOTCH2NOTCH2 isoform 1. (2612 aa)
WNT9B-2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
UMODUMOD isoform 1. (690 aa)
ENSPTRP00000077262annotation not available (314 aa)
TFAP2BTranscription factor AP-2 beta. (467 aa)
HS2ST1T0142978 isoform 1. (356 aa)
CTNNBIP1Catenin, beta interacting protein 1. (81 aa)
TACSTD2Tumor associated calcium signal transducer 2. (324 aa)
LGR4LGR4 isoform 2. (951 aa)
FOXD1FOXD1 isoform 1. (439 aa)
PAX2PAX2 isoform 1. (417 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
LAMA5Laminin, alpha 5. (2203 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
DCHS1DCHS1 isoform 1. (3298 aa)
WT1WT1 transcription factor. (514 aa)
PTCH1PTCH1 isoform 8. (1428 aa)
HS3ST3A1Sulfotransferase; Belongs to the sulfotransferase 1 family. (374 aa)
NPNTNPNT isoform 10. (611 aa)
PAX8PAX8 isoform 1. (456 aa)
CK820_G0054628PKD1 isoform 4. (3384 aa)
MTSS1MTSS I-BAR domain containing 1. (759 aa)
LZTS2Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (669 aa)
HNF1BHNF1 homeobox B. (557 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
HES5-2Hes family bHLH transcription factor 5. (165 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
AQP11Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (271 aa)
ACAT1Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (427 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
SOX8SOX8 isoform 1. (446 aa)
IRX3Iroquois homeobox 3. (500 aa)
WNK4WNK lysine deficient protein kinase 4. (1282 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
GREB1Growth regulating estrogen receptor binding 1. (1949 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
TMEM59LTransmembrane protein 59-like. (343 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
GZF1GDNF inducible zinc finger protein 1. (711 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (968 aa)
IRX2Iroquois homeobox 2. (471 aa)
IRX1Iroquois homeobox 1. (480 aa)
ADAMTS16ADAM metallopeptidase with thrombospondin type 1 motif 16. (1224 aa)
KLHL3Kelch like family member 3. (608 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
TCF21Transcription factor 21. (179 aa)
AHI1Abelson helper integration site 1. (1196 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
HOXA11HOXA11 isoform 2. (313 aa)
AQP1Aquaporin-1 isoform X2. (269 aa)
GLI3Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
CALB1CALB1 isoform 3. (261 aa)
COMMD5COMM domain containing 5. (224 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (219 aa)
HES5Hes family bHLH transcription factor 5. (165 aa)
HS3ST3B1Sulfotransferase; Belongs to the sulfotransferase 1 family. (390 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
GDNFGlial cell derived neurotrophic factor. (228 aa)
KIF26BKIF26B isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2108 aa)
LHX1LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis (By similarity). (406 aa)
HOXD11HOXD11 isoform 2. (339 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (221 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
PBX1Pre-B-cell leukemia homeobox 1. (486 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
FMN1FMN1 isoform 1. (1425 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
SALL1SALL1 isoform 2. (1326 aa)
GATA3GATA binding protein 3. (444 aa)
CK820_G0056924NPIPA2 isoform 1. (277 aa)
ILKIntegrin-linked kinase. (533 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (926 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. (288 aa)
GPC3Glypican-3 alpha subunit; Cell surface proteoglycan that bears heparan sulfate (By similarity). Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins (By similarity). Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation (By similarity). Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled recept [...] (563 aa)
GREB1LGREB1 like retinoic acid receptor coactivator. (1967 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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