STRINGSTRING
CK820_G0021068 CK820_G0021068 KDF1 KDF1 AGO3 AGO3 CDKN2C CDKN2C PRRX1 PRRX1 PTPRC PTPRC LTBP3 LTBP3 OVOL1 OVOL1 FGF4 FGF4 WNT11 WNT11 YAP1 YAP1 WNT10B WNT10B WNT1 WNT1 KITLG KITLG FGF9 FGF9 IRS2 IRS2 ELL3 ELL3 TP53 TP53 NF1 NF1 KAT7 KAT7 SOX9 SOX9 SIRT6 SIRT6 TGFB1 TGFB1 SOX18 SOX18 DGCR8 DGCR8 TP63 TP63 KDR KDR VEGFC VEGFC TERT-2 TERT-2 PIM1 PIM1 GLI3 GLI3 SNAI2 SNAI2 SOX17 SOX17 NOTCH1 NOTCH1 CITED1 CITED1 ACE ACE TIAL1 TIAL1 CTNNB1 CTNNB1 HMGA2 HMGA2 SFN SFN NFIB NFIB ATXN1L ATXN1L PBX1 PBX1 ZFP36L1 ZFP36L1 TERT TERT FBLN1 FBLN1 KDM1A KDM1A THPO THPO PDCD2 PDCD2 EIF2AK2 EIF2AK2 RUNX2 RUNX2 LOC736481 LOC736481 N4BP2L2 N4BP2L2 HOXA3 HOXA3 HOXA3-2 HOXA3-2 ID4 ID4 NF2 NF2 NR2E1 NR2E1 CD109 CD109 TGFBR2 TGFBR2 FGF8 FGF8 SHH SHH RBPJ RBPJ FERMT2 FERMT2 RARB RARB RARG RARG FGF10 FGF10 HMX2 HMX2 CK820_G0045089 CK820_G0045089 TBX3 TBX3 HNRNPU HNRNPU WNT5A WNT5A EPCAM EPCAM PTCH1 PTCH1 CCNE1 CCNE1 FERMT1 FERMT1 SOX11 SOX11 NR2E1-2 NR2E1-2 SHOX2 SHOX2 IRF6 IRF6 OVOL2 OVOL2 OSR2 OSR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CK820_G0021068Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (341 aa)
KDF1Keratinocyte differentiation factor 1. (398 aa)
AGO3Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa)
CDKN2CCyclin-dependent kinase inhibitor 2C (P18, inhibits CDK4). (168 aa)
PRRX1Paired related homeobox 1. (245 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1306 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1297 aa)
OVOL1Ovo like transcriptional repressor 1. (267 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
YAP1Yes-associated protein 1. (508 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
IRS2IRS2 isoform 1. (1340 aa)
ELL3Elongation factor RNA polymerase II-like 3. (397 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
NF1Neurofibromin 1. (2839 aa)
KAT7Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (611 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
SIRT6SIRT6 isoform 1. (355 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
SOX18SOX18 isoform 1. (384 aa)
DGCR8DiGeorge syndrome critical region gene 8. (773 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa)
TERT-2Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (762 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (535 aa)
GLI3Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
SOX17SOX17 isoform 1. (416 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (219 aa)
ACEAngiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. (1306 aa)
TIAL1TIA1 cytotoxic granule-associated RNA binding protein-like 1. (375 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
HMGA2High mobility group AT-hook 2. (147 aa)
SFNSFN isoform 1; Belongs to the 14-3-3 family. (248 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
ATXN1LATXN1L isoform 2. (689 aa)
PBX1Pre-B-cell leukemia homeobox 1. (486 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
TERTTelomerase reverse transcriptase. (360 aa)
FBLN1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (721 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (876 aa)
THPOTHPO isoform 1. (353 aa)
PDCD2Programmed cell death 2. (371 aa)
EIF2AK2Eukaryotic translation initiation factor 2-alpha kinase 2. (552 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (569 aa)
LOC736481Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (400 aa)
N4BP2L2N4BP2L2 isoform 1. (737 aa)
HOXA3HOXA3 isoform 3. (443 aa)
HOXA3-2Homeobox A3. (443 aa)
ID4Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein. (161 aa)
NF2Neurofibromin 2 (Merlin). (595 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (422 aa)
CD109CD109 isoform 3. (1446 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
FERMT2Fermitin family member 2. (706 aa)
RARBRetinoic acid receptor, beta. (448 aa)
RARGRetinoic acid receptor, gamma. (456 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
HMX2H6 family homeobox 2. (273 aa)
CK820_G0045089RANBP3 isoform 23. (97 aa)
TBX3T-box transcription factor 3. (743 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U (Scaffold attachment factor A). (825 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
EPCAMEPCAM isoform 1. (338 aa)
PTCH1PTCH1 isoform 8. (1428 aa)
CCNE1CCNE1 isoform 1; Belongs to the cyclin family. (411 aa)
FERMT1Fermitin family member 1. (677 aa)
SOX11Transcription factor SOX. (441 aa)
NR2E1-2Nuclear receptor subfamily 2 group E member 1. (385 aa)
SHOX2SHOX2 isoform 2. (343 aa)
IRF6Interferon regulatory factor 6. (467 aa)
OVOL2Ovo like zinc finger 2. (275 aa)
OSR2Protein odd-skipped-related 2 isoform X4. (433 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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