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ND2 ND2 IFI6 IFI6 ATP5IF1 ATP5IF1 SESN2 SESN2 PRDX1 PRDX1 CCN1 CCN1 NCF2 NCF2 INAVA INAVA DDIT4 DDIT4 PRDX3 PRDX3 BNIP3 BNIP3 HBB HBB HBE1 HBE1 CAT CAT NDUFS3 NDUFS3 PRDX5 PRDX5 CCS CCS APOA4 APOA4 TIGAR TIGAR LRRK2 LRRK2 GLS2 GLS2 RIPK3 RIPK3 DUOX2 DUOX2 DUOXA2 DUOXA2 DUOXA1 DUOXA1 ENSPTRP00000012856 ENSPTRP00000012856 HBZ HBZ MT3 MT3 NQO1 NQO1 TP53 TP53 NOS2 NOS2 EPX EPX LPO LPO MPO MPO VAV1 VAV1 ACP5 ACP5 PRDX2 PRDX2 SOD1 SOD1 CBS CBS PDGFB PDGFB TAFA4 TAFA4 NRROS NRROS SOD3 SOD3 NNT NNT NDUFS4 NDUFS4 EDN1 EDN1 CYB5R4 CYB5R4 SESN1 SESN1 NOX3 NOX3 NCF1 NCF1 PDK4 PDK4 IMMP2L IMMP2L NOS3 NOS3 PXDNL PXDNL RFK RFK FANCC FANCC MAOB MAOB GBF1 GBF1 HBM HBM CYBB CYBB NOX4 NOX4 GPX3 GPX3 HBG1 HBG1 SLC1A1 SLC1A1 P2RX7 P2RX7 PRG3 PRG3 GPX1 GPX1 NOX5 NOX5 DRD5 DRD5 HBD HBD CK820_G0015936 CK820_G0015936 HBG2 HBG2 CYP1A1 CYP1A1 SH3PXD2B SH3PXD2B NOX1 NOX1 ATP7A ATP7A DUOX1 DUOX1 ENSPTRP00000066724 ENSPTRP00000066724 HBA1 HBA1 NDUFA13 NDUFA13 ACOX1 ACOX1 NDUFS1 NDUFS1 NOX4-2 NOX4-2 NDUFA13-2 NDUFA13-2 LOC736283 LOC736283 ENSPTRP00000070073 ENSPTRP00000070073 CYP1A2 CYP1A2 ENSPTRP00000070902 ENSPTRP00000070902 NOXA1 NOXA1 ENSPTRP00000072249 ENSPTRP00000072249 NCF4 NCF4 IL19 IL19 LOC100615743 LOC100615743 TPO TPO SFTPD SFTPD MPV17L MPV17L HBQ1 HBQ1 PARK7 PARK7 SH3PXD2A SH3PXD2A LOC465127 LOC465127 ENSPTRP00000079686 ENSPTRP00000079686 NOXO1 NOXO1 PLA2R1 PLA2R1 ENSPTRP00000081633 ENSPTRP00000081633 PREX1 PREX1 SOD2 SOD2 ENSPTRP00000084198 ENSPTRP00000084198 ENSPTRP00000084468 ENSPTRP00000084468 ENSPTRP00000084892 ENSPTRP00000084892 CCN2 CCN2 IFI6-2 IFI6-2 BCL2 BCL2 HBA2 HBA2 PXDN PXDN PAX2 PAX2 CYBA CYBA PRDX4 PRDX4 ENSPTRP00000092702 ENSPTRP00000092702
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ND2NADH-ubiquinone oxidoreductase chain 2; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (347 aa)
IFI6Interferon alpha-inducible protein 6; Plays a role in apoptosis, negatively regulating the intrinsinc apoptotic signaling pathway and TNFSF10-induced apoptosis (By similarity). However, it has also been shown to have a pro- apoptotic activity (By similarity). May have an antiviral activity (By similarity); Belongs to the IFI6/IFI27 family. (134 aa)
ATP5IF1ATP synthase inhibitory factor subunit 1. (106 aa)
SESN2SESN2 isoform 1. (480 aa)
PRDX1PRDX1 isoform 1. (199 aa)
CCN1CCN family member 1; Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 (By similarity). CCN1-mediated gene regulation is dependent on heparin-binding (By similarity). Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 (By similarity). Promotes cell adhesion and adhesive s [...] (381 aa)
NCF2Neutrophil cytosolic factor 2. (526 aa)
INAVAINAVA isoform 1. (663 aa)
DDIT4DNA-damage-inducible transcript 4. (232 aa)
PRDX3PRDX3 isoform 1. (256 aa)
BNIP3BCL2 interacting protein 3. (259 aa)
HBBHemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. (147 aa)
HBE1Hemoglobin subunit epsilon; The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin. (147 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
NDUFS3NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (264 aa)
PRDX5Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (214 aa)
CCSCopper chaperone for superoxide dismutase. (274 aa)
APOA4Apolipoprotein A4. (396 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (270 aa)
LRRK2Leucine-rich repeat kinase 2. (2527 aa)
GLS2GLS2 isoform 4. (602 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (518 aa)
DUOX2DUOX2 isoform 1. (1548 aa)
DUOXA2Dual oxidase maturation factor 2. (320 aa)
DUOXA1Dual oxidase maturation factor 1. (464 aa)
ENSPTRP00000012856annotation not available (109 aa)
HBZHemoglobin subunit zeta; The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin; Belongs to the globin family. (142 aa)
MT3MT3 isoform 5; Belongs to the metallothionein superfamily. Type 1 family. (113 aa)
NQO1NAD(P)H quinone dehydrogenase 1. (274 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1196 aa)
EPXEosinophil peroxidase. (715 aa)
LPOLPO isoform 1. (712 aa)
MPOMyeloperoxidase. (745 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (325 aa)
PRDX2PRDX2 isoform 1. (198 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
CBSCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (551 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
TAFA4FAM19A4 isoform 2. (137 aa)
NRROSNegative regulator of reactive oxygen species. (692 aa)
SOD3Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (240 aa)
NNTNicotinamide nucleotide transhydrogenase. (1086 aa)
NDUFS4NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (175 aa)
EDN1EDN1 isoform 1. (212 aa)
CYB5R4Cytochrome b5 reductase 4. (521 aa)
SESN1SESN1 isoform 1. (551 aa)
NOX3NADPH oxidase 3. (568 aa)
NCF1Neutrophil cytosolic factor 1. (390 aa)
PDK4Protein-serine/threonine kinase. (411 aa)
IMMP2LMitochondrial inner membrane protease subunit. (175 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1203 aa)
PXDNLPXDNL isoform 2. (1463 aa)
RFKRFK isoform 1. (162 aa)
FANCCFanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (558 aa)
MAOBAmine oxidase. (520 aa)
GBF1Golgi brefeldin A resistant guanine nucleotide exchange factor 1. (1859 aa)
HBMHemoglobin subunit mu; Belongs to the globin family. (141 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
NOX4NADPH oxidase 4. (578 aa)
GPX3GPX3 isoform 3. (225 aa)
HBG1Hemoglobin subunit gamma-1; Gamma chains make up the fetal hemoglobin F, in combination with alpha chains. (147 aa)
SLC1A1Amino acid transporter. (524 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
PRG3Proteoglycan 3, pro eosinophil major basic protein 2. (225 aa)
GPX1Glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown. (200 aa)
NOX5NADPH oxidase 5. (737 aa)
DRD5D(1B) dopamine receptor. (477 aa)
HBDHemoglobin subunit delta; Belongs to the globin family. (147 aa)
CK820_G0015936C12orf76 isoform 1. (107 aa)
HBG2Hemoglobin subunit gamma-2; Gamma chains make up the fetal hemoglobin F, in combination with alpha chains. (147 aa)
CYP1A1Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. (512 aa)
SH3PXD2BSH3 and PX domains 2B. (911 aa)
NOX1NADPH oxidase 1. (564 aa)
ATP7AATPase, Cu++ transporting, alpha polypeptide. (1500 aa)
DUOX1DUOX1 isoform 1. (1551 aa)
ENSPTRP00000066724annotation not available (166 aa)
HBA1Hemoglobin subunit alpha; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family. (142 aa)
NDUFA13NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in [...] (144 aa)
ACOX1Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (660 aa)
NDUFS1NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized (By sim [...] (740 aa)
NOX4-2NADPH oxidase 4. (225 aa)
NDUFA13-2NADH:ubiquinone oxidoreductase subunit A13. (150 aa)
LOC736283Glutathione peroxidase 1 pseudogene. (188 aa)
ENSPTRP00000070073annotation not available (155 aa)
CYP1A2Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. (517 aa)
ENSPTRP00000070902annotation not available (168 aa)
NOXA1NOXA1 isoform 2. (87 aa)
ENSPTRP00000072249annotation not available (396 aa)
NCF4Neutrophil cytosolic factor 4. (368 aa)
IL19IL19 isoform 1. (215 aa)
LOC100615743Peroxiredoxin-1-like. (171 aa)
TPOTPO isoform 5. (847 aa)
SFTPDSurfactant protein D. (375 aa)
MPV17LUncharacterized protein; Belongs to the peroxisomal membrane protein PXMP2/4 family. (196 aa)
HBQ1Hemoglobin subunit theta 1; Belongs to the globin family. (142 aa)
PARK7PARK7 isoform 1. (189 aa)
SH3PXD2ASH3 and PX domains 2A. (1133 aa)
LOC465127Dopamine receptor D5 pseudogene. (432 aa)
ENSPTRP00000079686annotation not available (213 aa)
NOXO1NOXO1 isoform 6. (482 aa)
PLA2R1PLA2R1 isoform 2. (1466 aa)
ENSPTRP00000081633annotation not available (139 aa)
PREX1Phosphatidylinositol-3,4, 5-trisphosphate-dependent Rac exchange factor 1. (1659 aa)
SOD2Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (238 aa)
ENSPTRP00000084198annotation not available (136 aa)
ENSPTRP00000084468annotation not available (154 aa)
ENSPTRP00000084892annotation not available (374 aa)
CCN2CTGF isoform 1. (349 aa)
IFI6-2Interferon alpha inducible protein 6. (134 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
HBA2Pan troglodytes hemoglobin subunit alpha 2 (HBA2), mRNA. (145 aa)
PXDNPeroxidasin homolog. (1479 aa)
PAX2PAX2 isoform 1. (417 aa)
CYBACytochrome b-245 alpha chain. (210 aa)
PRDX4PRDX4 isoform 2. (271 aa)
ENSPTRP00000092702annotation not available (482 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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