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CASQ2 CASQ2 CACNA1C CACNA1C LOC736481 LOC736481 KCNJ3 KCNJ3 TRPM4 TRPM4 HCN4 HCN4 PKP2 PKP2 KCNA5 KCNA5 SCN10A SCN10A CACNB2 CACNB2 KCNJ5 KCNJ5 ENSPTRP00000092784 ENSPTRP00000092784 SCN4B SCN4B KCNQ1 KCNQ1 NUP155 NUP155 CACNA1D CACNA1D CACNA2D1 CACNA2D1 SCN5A SCN5A TBX5 TBX5 CACNA1G CACNA1G RYR2 RYR2 CK820_G0042363 CK820_G0042363 KCNE5 KCNE5 RNF207 RNF207 ANK2 ANK2 KCNN2 KCNN2 SCN3B SCN3B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CASQ2Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (399 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
LOC736481Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (400 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (501 aa)
TRPM4Transient receptor potential cation channel, subfamily M, member 4. (1306 aa)
HCN4Hyperpolarization activated cyclic nucleotide gated potassium channel 4. (1203 aa)
PKP2PKP2 isoform 1. (837 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (602 aa)
SCN10ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1959 aa)
CACNB2Calcium voltage-gated channel auxiliary subunit beta 2. (660 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
ENSPTRP00000092784annotation not available (75 aa)
SCN4BSodium voltage-gated channel beta subunit 4. (228 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (676 aa)
NUP155Nucleoporin 155kDa. (1391 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1103 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2016 aa)
TBX5T-box transcription factor 5. (518 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2377 aa)
RYR2RYR2 isoform 1. (4941 aa)
CK820_G0042363TRPM4 isoform 1. (1251 aa)
KCNE5Potassium voltage-gated channel subfamily E regulatory subunit 5. (142 aa)
RNF207Ring finger protein 207. (634 aa)
ANK2ANK2 isoform 1. (3957 aa)
KCNN2Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2. (843 aa)
SCN3BSodium voltage-gated channel beta subunit 3. (215 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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