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HCN4 HCN4 PKP2 PKP2 KCNA5 KCNA5 CACNA1C CACNA1C SCN3B SCN3B CTNNA3 CTNNA3 CASQ2 CASQ2 TNNI3K TNNI3K KCNE5 KCNE5 ENSPTRP00000093588 ENSPTRP00000093588 KCNJ5 KCNJ5 ENSPTRP00000092784 ENSPTRP00000092784 SCN4B SCN4B ATP1A1 ATP1A1 KCNQ1 KCNQ1 GJA5 GJA5 ATP1A2 ATP1A2 GJC1 GJC1 NUP155 NUP155 CACNA1D CACNA1D ENSPTRP00000072925 ENSPTRP00000072925 CACNA2D1 CACNA2D1 SCN5A SCN5A TBX5 TBX5 ATP1A3 ATP1A3 LOC736481 LOC736481 ENSPTRP00000066578 ENSPTRP00000066578 CACNA1G CACNA1G ENSPTRP00000065655 ENSPTRP00000065655 RYR2 RYR2 SLC8A1 SLC8A1 CXADR-2 CXADR-2 CK820_G0042363 CK820_G0042363 ATP1B2 ATP1B2 RNF207 RNF207 ANK2 ANK2 CACNB2 CACNB2 SCN10A SCN10A DSP DSP KCNN2 KCNN2 CXADR CXADR KCNJ3 KCNJ3 FKBP1B FKBP1B TRPM4 TRPM4 PRKACA PRKACA DSG2 DSG2 DSC2 DSC2 JUP JUP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HCN4Hyperpolarization activated cyclic nucleotide gated potassium channel 4. (1203 aa)
PKP2PKP2 isoform 1. (837 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (602 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
SCN3BSodium voltage-gated channel beta subunit 3. (215 aa)
CTNNA3CTNNA3 isoform 1. (895 aa)
CASQ2Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (399 aa)
TNNI3KTNNI3K isoform 2. (835 aa)
KCNE5Potassium voltage-gated channel subfamily E regulatory subunit 5. (142 aa)
ENSPTRP00000093588annotation not available (361 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
ENSPTRP00000092784annotation not available (75 aa)
SCN4BSodium voltage-gated channel beta subunit 4. (228 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1027 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (676 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
GJC1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (396 aa)
NUP155Nucleoporin 155kDa. (1391 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
ENSPTRP00000072925annotation not available (372 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1103 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2016 aa)
TBX5T-box transcription factor 5. (518 aa)
ATP1A3ATP1A3 isoform 2; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1287 aa)
LOC736481Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (400 aa)
ENSPTRP00000066578annotation not available (310 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2377 aa)
ENSPTRP00000065655annotation not available (349 aa)
RYR2RYR2 isoform 1. (4941 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
CXADR-2CXADR Ig-like cell adhesion molecule. (188 aa)
CK820_G0042363TRPM4 isoform 1. (1251 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
RNF207Ring finger protein 207. (634 aa)
ANK2ANK2 isoform 1. (3957 aa)
CACNB2Calcium voltage-gated channel auxiliary subunit beta 2. (660 aa)
SCN10ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1959 aa)
DSPDSP isoform 1. (2871 aa)
KCNN2Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2. (843 aa)
CXADRCXADR Ig-like cell adhesion molecule. (365 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (501 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
TRPM4Transient receptor potential cation channel, subfamily M, member 4. (1306 aa)
PRKACAPRKACA isoform 7; Belongs to the protein kinase superfamily. (289 aa)
DSG2DSG2 isoform 1. (1118 aa)
DSC2DSC2 isoform 1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (901 aa)
JUPJunction plakoglobin. (745 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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