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AKAP9 AKAP9 HCN3 HCN3 CTNNA3 CTNNA3 SCN3B SCN3B CACNA1C CACNA1C KCNA5 KCNA5 PKP2 PKP2 HCN4 HCN4 YWHAE YWHAE JUP JUP KCNJ2 KCNJ2 DSC2 DSC2 DSG2 DSG2 TRPM4 TRPM4 BIN1 BIN1 KCNJ3 KCNJ3 KCNE4 KCNE4 KCNE1 KCNE1 HCN1 HCN1 ISL1 ISL1 DSP DSP CAV1 CAV1 CACNB2 CACNB2 ANK2 ANK2 KCNH2 KCNH2 KCNE2 KCNE2 KCNE5 KCNE5 KCND3 KCND3 KCNE3 KCNE3 CK820_G0042363 CK820_G0042363 AKAP9-2 AKAP9-2 CACNA1G CACNA1G ENSPTRP00000068927 ENSPTRP00000068927 SCN5A SCN5A CACNA2D1 CACNA2D1 SCN2B SCN2B ENSPTRP00000075494 ENSPTRP00000075494 CACNA1D CACNA1D CK820_G0013720 CK820_G0013720 ENSPTRP00000082446 ENSPTRP00000082446 LOC459638 LOC459638 ENSPTRP00000086934 ENSPTRP00000086934 KCNH6 KCNH6 KCNQ1 KCNQ1 HCN2 HCN2 CAMK2D CAMK2D ENSPTRP00000088766 ENSPTRP00000088766 SCN1B SCN1B ENSPTRP00000090501 ENSPTRP00000090501 SCN4B SCN4B ENSPTRP00000091918 ENSPTRP00000091918 ENSPTRP00000092784 ENSPTRP00000092784 KCNJ5 KCNJ5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKAP9A kinase (PRKA) anchor protein (Yotiao) 9. (3908 aa)
HCN3Hyperpolarization activated cyclic nucleotide gated potassium channel 3. (774 aa)
CTNNA3CTNNA3 isoform 1. (895 aa)
SCN3BSodium voltage-gated channel beta subunit 3. (215 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (602 aa)
PKP2PKP2 isoform 1. (837 aa)
HCN4Hyperpolarization activated cyclic nucleotide gated potassium channel 4. (1203 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide; Belongs to the 14-3-3 family. (255 aa)
JUPJunction plakoglobin. (745 aa)
KCNJ2Potassium inwardly-rectifying channel, subfamily J, member 2. (427 aa)
DSC2DSC2 isoform 1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (901 aa)
DSG2DSG2 isoform 1. (1118 aa)
TRPM4Transient receptor potential cation channel, subfamily M, member 4. (1306 aa)
BIN1Bridging integrator 1. (597 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (501 aa)
KCNE4Potassium voltage-gated channel subfamily E regulatory subunit 4. (221 aa)
KCNE1KCNE1B isoform 1. (132 aa)
HCN1HCN1 isoform 1. (886 aa)
ISL1ISL LIM homeobox 1. (349 aa)
DSPDSP isoform 1. (2871 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
CACNB2Calcium voltage-gated channel auxiliary subunit beta 2. (660 aa)
ANK2ANK2 isoform 1. (3957 aa)
KCNH2Potassium voltage-gated channel subfamily H member 2. (1159 aa)
KCNE2KCNE2 isoform 1. (123 aa)
KCNE5Potassium voltage-gated channel subfamily E regulatory subunit 5. (142 aa)
KCND3Potassium voltage-gated channel, Shal-related subfamily, member 3; Belongs to the potassium channel family. (655 aa)
KCNE3Potassium voltage-gated channel subfamily E regulatory subunit 3. (103 aa)
CK820_G0042363TRPM4 isoform 1. (1251 aa)
AKAP9-2A-kinase anchoring protein 9. (3896 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2377 aa)
ENSPTRP00000068927annotation not available (480 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2016 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1103 aa)
SCN2BSodium voltage-gated channel beta subunit 2. (215 aa)
ENSPTRP00000075494annotation not available (194 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
CK820_G0013720HCN2 isoform 1. (847 aa)
ENSPTRP00000082446annotation not available (194 aa)
LOC45963814-3-3 protein epsilon-like. (255 aa)
ENSPTRP00000086934annotation not available (467 aa)
KCNH6Potassium voltage-gated channel subfamily H member 6. (994 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (676 aa)
HCN2Hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2. (775 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (446 aa)
ENSPTRP00000088766annotation not available (199 aa)
SCN1BSodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. (268 aa)
ENSPTRP00000090501annotation not available (192 aa)
SCN4BSodium voltage-gated channel beta subunit 4. (228 aa)
ENSPTRP00000091918annotation not available (454 aa)
ENSPTRP00000092784annotation not available (75 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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