STRINGSTRING
PTGS2 PTGS2 NRP1 NRP1 MMRN2 MMRN2 CIB1 CIB1 PIK3C2A PIK3C2A RHOJ RHOJ SPRED1 SPRED1 MAP2K5 MAP2K5 HDAC5 HDAC5 MAP3K3 MAP3K3 HMOX1 HMOX1 RHOA RHOA PDCD10 PDCD10 FGFBP1 FGFBP1 KDR KDR FBXW7 FBXW7 PLK2 PLK2 MEOX2 MEOX2 HDAC9 HDAC9 JCAD JCAD KLF4 KLF4 NOTCH1 NOTCH1 ANXA1 ANXA1 FOXC2 FOXC2 GATA2 GATA2 CK820_G0012168 CK820_G0012168 TBXA2R TBXA2R FBXW9 FBXW9 THBS1 THBS1 FGF2 FGF2 DLL4 DLL4 ABL1 ABL1 NR2E1 NR2E1 SRPX2 SRPX2 STARD13 STARD13 ITGB1BP1 ITGB1BP1 CARD10 CARD10 AKT3 AKT3 HDAC7 HDAC7 NR2E1-2 NR2E1-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTGS2Prostaglandin-endoperoxide synthase 2 (Prostaglandin G/H synthase and cyclooxygenase). (604 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
MMRN2MMRN2 isoform 1. (949 aa)
CIB1Calcium and integrin binding 1. (231 aa)
PIK3C2APhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1686 aa)
RHOJRas homolog gene family, member J. (214 aa)
SPRED1Sprouty-related, EVH1 domain containing 1. (444 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1115 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (657 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (311 aa)
RHOARas homolog family member A. (193 aa)
PDCD10Programmed cell death 10. (212 aa)
FGFBP1Fibroblast growth factor binding protein 1. (234 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
FBXW7F-box and WD repeat domain containing 7. (707 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
MEOX2Mesenchyme homeobox 2. (302 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1066 aa)
JCADJCAD isoform 2. (1354 aa)
KLF4Kruppel-like factor 4 (Gut). (479 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
ANXA1Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of Fthe formyl peptide receptors (By similarity). Contribu [...] (346 aa)
FOXC2Forkhead box C2 (MFH-1, mesenchyme forkhead 1). (501 aa)
GATA2GATA binding protein 2. (480 aa)
CK820_G0012168ABL1 isoform 3. (1149 aa)
TBXA2RThromboxane A2 receptor; Belongs to the G-protein coupled receptor 1 family. (343 aa)
FBXW9F-box and WD repeat domain containing 9. (478 aa)
THBS1Thrombospondin 1. (1173 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. (288 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (696 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (422 aa)
SRPX2Sushi-repeat containing protein, X-linked 2. (469 aa)
STARD13StAR-related lipid transfer (START) domain containing 13. (1113 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
CARD10Caspase recruitment domain family member 10. (1032 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1016 aa)
NR2E1-2Nuclear receptor subfamily 2 group E member 1. (385 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.