STRINGSTRING
LEMD3 LEMD3 SKI SKI HSPA5 HSPA5 TRIM33 TRIM33 ARID4B ARID4B UCMA UCMA BAMBI BAMBI DKK1 DKK1 SIRT1 SIRT1 PBLD PBLD TET1 TET1 HTRA1 HTRA1 FAM89B FAM89B BRMS1 BRMS1 BCL9L BCL9L SORL1 SORL1 GDF3 GDF3 WNT1 WNT1 SPRY2 SPRY2 SNX6 SNX6 BRMS1L BRMS1L PPM1A PPM1A TGFB3 TGFB3 SPRED1 SPRED1 RBPMS2 RBPMS2 CILP CILP SMAD6 SMAD6 SKOR1 SKOR1 STUB1 STUB1 TP53 TP53 SOST SOST NOG NOG MTMR4 MTMR4 TWSG1 TWSG1 CIDEA CIDEA SMAD7 SMAD7 FSTL3 FSTL3 LINGO3 LINGO3 ZBTB7A ZBTB7A PIN1 PIN1 DAND5 DAND5 CILP2 CILP2 SPRED3-2 SPRED3-2 EMILIN1 EMILIN1 LRP2 LRP2 VWC2L VWC2L BMP2 BMP2 SLC2A10 SLC2A10 PPARA PPARA IL17RD IL17RD NRROS NRROS HTRA3 HTRA3 RASL11B RASL11B SFRP2 SFRP2 SAP30 SAP30 ING2 ING2 FST FST LEMD2 LEMD2 ZNF451 ZNF451 DACT2 DACT2 BMPER BMPER TBX20 TBX20 VWC2 VWC2 MAGI2 MAGI2 CAV1 CAV1 HIPK2 HIPK2 HTRA4 HTRA4 CCN3 CCN3 CER1 CER1 ASPN ASPN ENG ENG NOTCH1 NOTCH1 IGSF1 IGSF1 DLX1 DLX1 ADAMTSL2 ADAMTSL2 SPART SPART VEPH1 VEPH1 LTBP1 LTBP1 SIN3A SIN3A SMURF1 SMURF1 TNFAIP6 TNFAIP6 HDAC2 HDAC2 SPINT3 SPINT3 ADAM17 ADAM17 SFRP1 SFRP1 VASN VASN SNX25 SNX25 SUDS3 SUDS3 UBL3 UBL3 LOC745166 LOC745166 EID2 EID2 CAV2 CAV2 ENSPTRP00000061118 ENSPTRP00000061118 CK820_G0012168 CK820_G0012168 TMPRSS6 TMPRSS6 ENSPTRP00000062605 ENSPTRP00000062605 LOC100609513 LOC100609513 ENSPTRP00000063212 ENSPTRP00000063212 SPRED2 SPRED2 XBP1 XBP1 SAP30L SAP30L TGFBR3 TGFBR3 ENSPTRP00000066551 ENSPTRP00000066551 OGT OGT LOC748850 LOC748850 SOSTDC1 SOSTDC1 FBN1 FBN1 NBL1 NBL1 GLG1 GLG1 CHRDL2 CHRDL2 RBBP4 RBBP4 SKOR2 SKOR2 PMEPA1 PMEPA1 SKIL SKIL LRP1 LRP1 WFIKKN1 WFIKKN1 SAP130 SAP130 ING1 ING1 NKX2-1 NKX2-1 ABL1 ABL1 DNM2 DNM2 ONECUT1 ONECUT1 UBE2D3 UBE2D3 CD109 CD109 ENSPTRP00000075374 ENSPTRP00000075374 ENSPTRP00000075516 ENSPTRP00000075516 CTDSPL2 CTDSPL2 ACVR1 ACVR1 HDAC1 HDAC1 SINHCAF SINHCAF STRAP STRAP PPARG PPARG PRDM16 PRDM16 LOC454345 LOC454345 ENSPTRP00000079019 ENSPTRP00000079019 ENSPTRP00000079319 ENSPTRP00000079319 TGFB1I1 TGFB1I1 ENSPTRP00000080206 ENSPTRP00000080206 ENSPTRP00000080456 ENSPTRP00000080456 ONECUT2 ONECUT2 ENSPTRP00000081214 ENSPTRP00000081214 ENSPTRP00000081300 ENSPTRP00000081300 LDLRAD4 LDLRAD4 ENSPTRP00000082260 ENSPTRP00000082260 CHRDL1 CHRDL1 SPRY1 SPRY1 ENSPTRP00000084591 ENSPTRP00000084591 WFIKKN2 WFIKKN2 ENSPTRP00000085589 ENSPTRP00000085589 HJV HJV CHRD CHRD WNT5A WNT5A FZD1 FZD1 SMURF2 SMURF2 SOSTDC1-2 SOSTDC1-2 ENSPTRP00000089693 ENSPTRP00000089693 CRIM1 CRIM1 PDPK1 PDPK1 GREM2 GREM2 FBN2 FBN2 CHST11 CHST11 SPRED3 SPRED3 FZD1-2 FZD1-2 SIRT1-2 SIRT1-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LEMD3LEM domain containing 3. (911 aa)
SKIV-ski sarcoma viral oncogene homolog (Avian). (736 aa)
HSPA5Heat shock 70kDa protein 5 (Glucose-regulated protein, 78kDa); Belongs to the heat shock protein 70 family. (654 aa)
TRIM33Tripartite motif containing 33. (1127 aa)
ARID4BAT rich interactive domain 4B (RBP1-like). (1313 aa)
UCMAUCMA isoform 1. (138 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
DKK1Dickkopf-like protein 1. (289 aa)
SIRT1SIRT1 isoform 2. (751 aa)
PBLDPhenazine biosynthesis-like protein domain containing. (288 aa)
TET1TET1 isoform 1. (2136 aa)
HTRA1HtrA serine peptidase 1. (522 aa)
FAM89BFamily with sequence similarity 89 member B. (154 aa)
BRMS1BRMS1 transcriptional repressor and anoikis regulator. (246 aa)
BCL9LB-cell CLL/lymphoma 9-like. (1499 aa)
SORL1Sortilin related receptor 1. (2214 aa)
GDF3Growth differentiation factor 3. (364 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
SPRY2Sprouty homolog 2. (338 aa)
SNX6Sorting nexin; Involved in several stages of intracellular trafficking. (418 aa)
BRMS1LBreast cancer metastasis-suppressor 1-like. (323 aa)
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (455 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
SPRED1Sprouty-related, EVH1 domain containing 1. (444 aa)
RBPMS2RNA binding protein, mRNA processing factor 2. (209 aa)
CILPCartilage intermediate layer protein. (1184 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
SKOR1SKI family transcriptional corepressor 1. (962 aa)
STUB1STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase. (303 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
SOSTSOST isoform 1. (213 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
MTMR4Myotubularin related protein 4. (1195 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
CIDEACIDEA isoform 1. (253 aa)
SMAD7Mothers against decapentaplegic homolog. (491 aa)
FSTL3Follistatin-like 3 (Secreted glycoprotein). (263 aa)
LINGO3Leucine rich repeat and Ig domain containing 3. (592 aa)
ZBTB7AZinc finger and BTB domain containing 7A. (584 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (163 aa)
DAND5DAN domain BMP antagonist family member 5. (189 aa)
CILP2Cartilage intermediate layer protein 2. (1156 aa)
SPRED3-2Sprouty related EVH1 domain containing 3. (454 aa)
EMILIN1Elastin microfibril interfacer 1. (1016 aa)
LRP2LRP2 isoform 1. (4655 aa)
VWC2LVon Willebrand factor C domain containing 2 like. (222 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
SLC2A10Solute carrier family 2 (Facilitated glucose transporter), member 10; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (541 aa)
PPARAPeroxisome proliferator-activated receptor alpha. (467 aa)
IL17RDInterleukin 17 receptor D. (739 aa)
NRROSNegative regulator of reactive oxygen species. (692 aa)
HTRA3HtrA serine peptidase 3. (402 aa)
RASL11BRAS-like, family 11, member B. (248 aa)
SFRP2Secreted frizzled-related protein 2. (295 aa)
SAP30Sin3A-associated protein, 30kDa. (220 aa)
ING2Inhibitor of growth protein. (280 aa)
FSTFST isoform 1. (344 aa)
LEMD2LEM domain containing 2. (503 aa)
ZNF451Zinc finger protein 451. (1060 aa)
DACT2Dishevelled binding antagonist of beta catenin 2. (774 aa)
BMPERBMP binding endothelial regulator. (685 aa)
TBX20T-box transcription factor 20. (447 aa)
VWC2Von Willebrand factor C domain containing 2. (325 aa)
MAGI2Membrane associated guanylate kinase, WW and PDZ domain containing 2. (1283 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
HIPK2Homeodomain interacting protein kinase 2. (1198 aa)
HTRA4HtrA serine peptidase 4. (476 aa)
CCN3NOV isoform 1. (357 aa)
CER1CER1 isoform 1. (267 aa)
ASPNAsporin. (378 aa)
ENGENG isoform 1. (658 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
IGSF1Immunoglobulin superfamily member 1. (1341 aa)
DLX1Distal-less homeobox 1. (255 aa)
ADAMTSL2ADAMTSL2 isoform 2. (1059 aa)
SPARTSpastic paraplegia 20 (Troyer syndrome). (665 aa)
VEPH1Ventricular zone expressed PH domain homolog 1 (Zebrafish). (833 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1719 aa)
SIN3ASIN3 transcription regulator family member A. (1273 aa)
SMURF1E3 ubiquitin-protein ligase. (757 aa)
TNFAIP6Tumor necrosis factor, alpha-induced protein 6. (277 aa)
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (581 aa)
SPINT3Serine peptidase inhibitor, Kunitz type 3. (89 aa)
ADAM17ADAM17 isoform 3. (999 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
VASNVASN isoform 1. (673 aa)
SNX25Sorting nexin 25. (840 aa)
SUDS3SDS3 homolog, SIN3A corepressor complex component. (328 aa)
UBL3Ubiquitin-like protein. (117 aa)
LOC745166HSPA1A isoform 1; Belongs to the heat shock protein 70 family. (643 aa)
EID2EP300 interacting inhibitor of differentiation 2. (236 aa)
CAV2Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (B [...] (162 aa)
ENSPTRP00000061118annotation not available (140 aa)
CK820_G0012168ABL1 isoform 3. (1149 aa)
TMPRSS6TMPRSS6 isoform 2; Belongs to the peptidase S1 family. (824 aa)
ENSPTRP00000062605annotation not available (1156 aa)
LOC10060951378 kDa glucose-regulated protein pseudogene. (617 aa)
ENSPTRP00000063212annotation not available (75 aa)
SPRED2SPRED2 isoform 3. (432 aa)
XBP1XBP1 isoform 4. (381 aa)
SAP30LSAP30L isoform 1. (183 aa)
TGFBR3Transforming growth factor, beta receptor III. (861 aa)
ENSPTRP00000066551annotation not available (192 aa)
OGTOGT isoform 6. (1057 aa)
LOC748850HDAC2 isoform 9. (445 aa)
SOSTDC1Sclerostin domain containing 1. (230 aa)
FBN1FBN1 isoform 1. (2871 aa)
NBL1Neuroblastoma suppressor of tumorigenicity 1. (216 aa)
GLG1Golgi glycoprotein 1. (1203 aa)
CHRDL2CHRDL2 isoform 2. (452 aa)
RBBP4RB binding protein 4, chromatin remodeling factor. (425 aa)
SKOR2SKI family transcriptional corepressor 2. (1012 aa)
PMEPA1Prostate transmembrane protein, androgen induced 1. (287 aa)
SKILSKI like proto-oncogene. (684 aa)
LRP1LDL receptor related protein 1. (4544 aa)
WFIKKN1WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1. (548 aa)
SAP130Sin3A-associated protein, 130kDa. (1083 aa)
ING1Inhibitor of growth protein. (421 aa)
NKX2-1NKX2-1 isoform 1. (401 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
DNM2DNM2 isoform 5; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (870 aa)
ONECUT1One cut domain family member. (465 aa)
UBE2D3Ubiquitin conjugating enzyme E2 D3; Belongs to the ubiquitin-conjugating enzyme family. (149 aa)
CD109CD109 isoform 3. (1446 aa)
ENSPTRP00000075374annotation not available (236 aa)
ENSPTRP00000075516annotation not available (322 aa)
CTDSPL2CTD (Carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2. (466 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
SINHCAFFamily with sequence similarity 60, member A. (221 aa)
STRAPSerine/threonine kinase receptor associated protein. (363 aa)
PPARGPeroxisome proliferator-activated receptor gamma isoform X2. (505 aa)
PRDM16PRDM16 isoform 4. (1276 aa)
LOC454345NOMO3 isoform 2. (1267 aa)
ENSPTRP00000079019annotation not available (165 aa)
ENSPTRP00000079319annotation not available (185 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (470 aa)
ENSPTRP00000080206annotation not available (395 aa)
ENSPTRP00000080456annotation not available (1174 aa)
ONECUT2One cut domain family member. (504 aa)
ENSPTRP00000081214annotation not available (185 aa)
ENSPTRP00000081300annotation not available (154 aa)
LDLRAD4Low density lipoprotein receptor class A domain containing 4. (306 aa)
ENSPTRP00000082260annotation not available (202 aa)
CHRDL1CHRDL1 isoform 3. (458 aa)
SPRY1Sprouty homolog 1, antagonist of FGF signaling. (319 aa)
ENSPTRP00000084591annotation not available (446 aa)
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2. (576 aa)
ENSPTRP00000085589annotation not available (393 aa)
HJVHFE2 isoform 1. (426 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (955 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
FZD1FZD1 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (580 aa)
SMURF2E3 ubiquitin-protein ligase. (744 aa)
SOSTDC1-2Sclerostin domain containing 1. (206 aa)
ENSPTRP00000089693annotation not available (226 aa)
CRIM1CRIM1 isoform 1. (1036 aa)
PDPK13-phosphoinositide dependent protein kinase-1. (542 aa)
GREM2Gremlin. (168 aa)
FBN2FBN2 isoform 1. (2912 aa)
CHST11Carbohydrate sulfotransferase. (352 aa)
SPRED3Sprouty related EVH1 domain containing 3. (410 aa)
FZD1-2Frizzled class receptor 1. (580 aa)
SIRT1-2Sirtuin 1. (751 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.