54 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	IFT27	Intraflagellar transport 27 homolog. (186 aa)
	MYO3B	MYO3B isoform 3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1341 aa)
	CTHRC1	Collagen triple helix repeat containing 1. (243 aa)
	CALB1	CALB1 isoform 3. (261 aa)
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
	OCM2	OCM2 isoform 1; Belongs to the parvalbumin family. (109 aa)
	HOXA1	HOXA1 isoform 2. (335 aa)
	OCM	OCM isoform 1; Belongs to the parvalbumin family. (109 aa)
	HEY2	Hairy/enhancer-of-split related with YRPW motif 2. (337 aa)
	SOBP	Sine oculis binding protein homolog. (873 aa)
	HPN	HPN isoform 1; Belongs to the peptidase S1 family. (417 aa)
	SOX9	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
	TBX2	T-box transcription factor 2. (712 aa)
	FZD2	FZD2 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (548 aa)
	DVL2	Dishevelled segment polarity protein 2. (736 aa)
	RPGRIP1L	RPGRIP1L isoform 4. (1269 aa)
	ADAM10	ADAM metallopeptidase domain 10. (748 aa)
	MYO3A	MYO3A isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1621 aa)
	TBX18	T-box transcription factor 18. (607 aa)
	NEUROG1	NEUROG1 isoform 1. (237 aa)
	CCNA2	CCNA2 isoform 1; Belongs to the cyclin family. (432 aa)
	MCM2	DNA helicase; Belongs to the MCM family. (904 aa)
	GRHL3	Grainyhead like transcription factor 3. (626 aa)
	KCNK3	Potassium channel subfamily K member. (394 aa)
	EPHA4	EPH receptor A4. (986 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	PTK7	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1078 aa)
	KCNQ1	Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (676 aa)
	OCM-2	Oncomodulin. (136 aa)
	GABRA5	Gamma-aminobutyric acid type A receptor alpha5 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (462 aa)
	DCHS1	DCHS1 isoform 1. (3298 aa)
	PAX2	PAX2 isoform 1. (417 aa)
	HOXA1-2	Homeobox A1. (335 aa)
	SLC17A8	SLC17A8 isoform 1. (589 aa)
	PAFAH1B1	Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (413 aa)
	CECR2	CECR2 isoform 2. (1485 aa)
	IFT20	IFT20 isoform 5. (164 aa)
	DCANP1	LOW QUALITY PROTEIN: dendritic cell nuclear protein 1. (237 aa)
	PVALB	PVALB isoform 1; Belongs to the parvalbumin family. (110 aa)
	TIFAB	TIFAB isoform 1. (161 aa)
	DVL1	Segment polarity protein dishevelled homolog DVL-1; Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By simi [...] (743 aa)
	SLC26A5	Prestin; Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (744 aa)
	TBX1	TBX1 isoform 1. (478 aa)
	OCM2-2	Putative oncomodulin-2 isoform X1. (136 aa)
	GATA3	GATA binding protein 3. (444 aa)
	HES1	Hes family bHLH transcription factor 1. (280 aa)
	ZEB1	Zinc finger E-box binding homeobox 1. (1127 aa)
	POU3F4	POU domain protein. (361 aa)
	SLITRK6	SLITRK6 isoform 1. (841 aa)
	KCNK2	Potassium two pore domain channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (426 aa)
	TSHR	Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (764 aa)
	GABRB2	Gamma-aminobutyric acid type A receptor beta2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (512 aa)
	FRZB	Frizzled-related protein. (325 aa)
	GATA2	GATA binding protein 2. (480 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAM10	EPHA4	ENSPTRP00000012167	ENSPTRP00000086131	ADAM metallopeptidase domain 10.	EPH receptor A4.	0.608
CALB1	PVALB	ENSPTRP00000034910	ENSPTRP00000075273	CALB1 isoform 3.	PVALB isoform 1; Belongs to the parvalbumin family.	0.708
CALB1	SLC17A8	ENSPTRP00000034910	ENSPTRP00000078860	CALB1 isoform 3.	SLC17A8 isoform 1.	0.487
CCNA2	MCM2	ENSPTRP00000028181	ENSPTRP00000026448	CCNA2 isoform 1; Belongs to the cyclin family.	DNA helicase; Belongs to the MCM family.	0.809
DVL1	DVL2	ENSPTRP00000073737	ENSPTRP00000014781	Segment polarity protein dishevelled homolog DVL-1; Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By simi [...]	Dishevelled segment polarity protein 2.	0.906
DVL1	FRZB	ENSPTRP00000073737	ENSPTRP00000021732	Segment polarity protein dishevelled homolog DVL-1; Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By simi [...]	Frizzled-related protein.	0.578
DVL1	FZD2	ENSPTRP00000073737	ENSPTRP00000015783	Segment polarity protein dishevelled homolog DVL-1; Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By simi [...]	FZD2 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family.	0.754
DVL1	PTK7	ENSPTRP00000073737	ENSPTRP00000087445	Segment polarity protein dishevelled homolog DVL-1; Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By simi [...]	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.741
DVL1	WNT5A	ENSPTRP00000073737	ENSPTRP00000086163	Segment polarity protein dishevelled homolog DVL-1; Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By simi [...]	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.823
DVL2	DVL1	ENSPTRP00000014781	ENSPTRP00000073737	Dishevelled segment polarity protein 2.	Segment polarity protein dishevelled homolog DVL-1; Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By simi [...]	0.906
DVL2	FRZB	ENSPTRP00000014781	ENSPTRP00000021732	Dishevelled segment polarity protein 2.	Frizzled-related protein.	0.763
DVL2	FZD2	ENSPTRP00000014781	ENSPTRP00000015783	Dishevelled segment polarity protein 2.	FZD2 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family.	0.982
DVL2	PTK7	ENSPTRP00000014781	ENSPTRP00000087445	Dishevelled segment polarity protein 2.	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.571
DVL2	WNT5A	ENSPTRP00000014781	ENSPTRP00000086163	Dishevelled segment polarity protein 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.965
EPHA4	ADAM10	ENSPTRP00000086131	ENSPTRP00000012167	EPH receptor A4.	ADAM metallopeptidase domain 10.	0.608
EYA1	GATA3	ENSPTRP00000034805	ENSPTRP00000064658	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	GATA binding protein 3.	0.472
EYA1	NEUROG1	ENSPTRP00000034805	ENSPTRP00000029519	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	NEUROG1 isoform 1.	0.456
EYA1	PAX2	ENSPTRP00000034805	ENSPTRP00000091068	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	PAX2 isoform 1.	0.723
FRZB	DVL1	ENSPTRP00000021732	ENSPTRP00000073737	Frizzled-related protein.	Segment polarity protein dishevelled homolog DVL-1; Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By simi [...]	0.578
FRZB	DVL2	ENSPTRP00000021732	ENSPTRP00000014781	Frizzled-related protein.	Dishevelled segment polarity protein 2.	0.763