11 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BMP4-2	Bone morphogenetic protein 4. (408 aa)
	PAX2	PAX2 isoform 1. (417 aa)
	FOXD1	FOXD1 isoform 1. (439 aa)
	AGTR2	Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (363 aa)
	RET	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1116 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	SOX9	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
	SOX8	SOX8 isoform 1. (446 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (521 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	NOG	ENSPTRP00000010780	ENSPTRP00000016018	Bone morphogenetic protein 4.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.998
BMP4	SOX9	ENSPTRP00000010780	ENSPTRP00000016293	Bone morphogenetic protein 4.	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	0.509
BMP4-2	NOG	ENSPTRP00000080656	ENSPTRP00000016018	Bone morphogenetic protein 4.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.983
BMP4-2	SOX9	ENSPTRP00000080656	ENSPTRP00000016293	Bone morphogenetic protein 4.	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	0.509
FOXD1	PAX2	ENSPTRP00000092131	ENSPTRP00000091068	FOXD1 isoform 1.	PAX2 isoform 1.	0.459
NOG	BMP4	ENSPTRP00000016018	ENSPTRP00000010780	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	Bone morphogenetic protein 4.	0.998
NOG	BMP4-2	ENSPTRP00000016018	ENSPTRP00000080656	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	Bone morphogenetic protein 4.	0.983
NOG	SOX9	ENSPTRP00000016018	ENSPTRP00000016293	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	0.463
PAX2	FOXD1	ENSPTRP00000091068	ENSPTRP00000092131	PAX2 isoform 1.	FOXD1 isoform 1.	0.459
PAX2	WNT4	ENSPTRP00000091068	ENSPTRP00000063328	PAX2 isoform 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.472
SOX9	BMP4	ENSPTRP00000016293	ENSPTRP00000010780	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	Bone morphogenetic protein 4.	0.509
SOX9	BMP4-2	ENSPTRP00000016293	ENSPTRP00000080656	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	Bone morphogenetic protein 4.	0.509
SOX9	NOG	ENSPTRP00000016293	ENSPTRP00000016018	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.463
SOX9	WNT4	ENSPTRP00000016293	ENSPTRP00000063328	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.607
WNT4	PAX2	ENSPTRP00000063328	ENSPTRP00000091068	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	PAX2 isoform 1.	0.472
WNT4	SOX9	ENSPTRP00000063328	ENSPTRP00000016293	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	0.607