(81 nodes) Cellular senescence network (Pan troglodytes)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

Your Input:
	SPI1	Spi-1 proto-oncogene. (270 aa)
	PRMT6	Protein arginine methyltransferase 6; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (375 aa)
	LMNA	LMNA isoform 8; Belongs to the intermediate filament family. (664 aa)
	SIRT1-2	Sirtuin 1. (751 aa)
	WRN	WRN RecQ like helicase. (1446 aa)
	MIF	Macrophage migration inhibitory factor. (115 aa)
	ENSPTRP00000088520	annotation not available (242 aa)
	ENSPTRP00000087196	annotation not available (261 aa)
	ENSPTRP00000085517	annotation not available (294 aa)
	TBX3	T-box transcription factor 3. (743 aa)
	ENSPTRP00000084796	annotation not available (84 aa)
	CK820_G0045089	RANBP3 isoform 23. (97 aa)
	ENSPTRP00000084126	annotation not available (117 aa)
	CK820_G0053450-2	MAP2K3 isoform 2. (298 aa)
	CDKN2B	Cyclin-dependent kinase inhibitor 2B (P15, inhibits CDK4). (138 aa)
	PLA2R1	PLA2R1 isoform 2. (1466 aa)
	CITED2	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
	SMC6	Structural maintenance of chromosomes 6. (1160 aa)
	OPA1	OPA1 mitochondrial dynamin like GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (1015 aa)
	CDKN2A	Cyclin-dependent kinase inhibitor 2A (Melanoma, p16, inhibits CDK4). (173 aa)
	ENSPTRP00000075745	annotation not available (296 aa)
	HMGA1	High mobility group protein HMG-I/HMG-Y. (201 aa)
	LOC737257	Nucleophosmin pseudogene. (312 aa)
	LOC107966301	Melanoma-associated antigen 2. (314 aa)
	MAPK11	Mitogen-activated protein kinase. (364 aa)
	ENSPTRP00000074371	annotation not available (264 aa)
	MAP2K7	Mitogen-activated protein kinase kinase 7. (438 aa)
	ABL1	Tyrosine-protein kinase. (1149 aa)
	ENSPTRP00000071419	annotation not available (371 aa)
	MAPK10	Mitogen-activated protein kinase. (551 aa)
	LOC101057227	High mobility group protein HMG-I/HMG-Y-like isoform X1. (189 aa)
	ENSPTRP00000069037	annotation not available (328 aa)
	LOC107971228	Melanoma-associated antigen 2. (314 aa)
	NPM1	NPM1 isoform 1. (294 aa)
	DNAJA3	DnaJ heat shock protein family (Hsp40) member A3. (480 aa)
	CDK2	CDK2 isoform 4; Belongs to the protein kinase superfamily. (346 aa)
	LOC741112	High mobility group protein HMG-I/HMG-Y-like. (96 aa)
	ARNTL	Aryl hydrocarbon receptor nuclear translocator-like. (628 aa)
	LOC743115	Nucleophosmin pseudogene. (255 aa)
	ENSPTRP00000066329	annotation not available (241 aa)
	MAPKAPK5	Mitogen-activated protein kinase-activated protein kinase 5. (487 aa)
	LOC107966301-2	MAGEA2 isoform 1. (314 aa)
	LOC740219	High mobility group protein HMG-I/HMG-Y. (164 aa)
	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (393 aa)
	MAP2K6	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (339 aa)
	CK820_G0012168	ABL1 isoform 3. (1149 aa)
	ENSPTRP00000061486	Dual specificity mitogen-activated protein kinase kinase 3 isoform X1. (178 aa)
	ULK3	Unc-51 like kinase 3. (483 aa)
	CDKN1A	Cyclin-dependent kinase inhibitor 1A (P21, Cip1). (276 aa)
	NPM1-2	NPM1 isoform 5. (306 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
	TERF2	Telomeric repeat binding factor 2. (542 aa)
	HMGA2	High mobility group AT-hook 2. (147 aa)
	MAP3K5	Mitogen-activated protein kinase kinase kinase 5. (1374 aa)
	PRELP	Proline and arginine rich end leucine rich repeat protein. (382 aa)
	SMC5	Structural maintenance of chromosomes 5. (1101 aa)
	MAPK8	Mitogen-activated protein kinase. (427 aa)
	NSMCE2	NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (247 aa)
	KAT6A	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (2002 aa)
	WNT16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
	SRF	Serum response factor (C-fos serum response element-binding transcription factor). (508 aa)
	MAPK14	Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
	MAPK9	Mitogen-activated protein kinase. (424 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	PRKCD	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
	C2AH2orf40	Chromosome 2 open reading frame 40. (148 aa)
	ID2	Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein. (134 aa)
	CALR	Calreticulin. (414 aa)
	TBX2	T-box transcription factor 2. (712 aa)
	MAP2K4	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
	MNT	MAX binding protein. (582 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1364 aa)
	PML	PML isoform 6. (836 aa)
	BRCA2	Breast cancer 2, early onset. (3418 aa)
	CDKN1B	Cyclin-dependent kinase inhibitor 1B (P27, Kip1). (198 aa)
	H2AFX	H2AFX isoform 1. (143 aa)
	KAT5	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa)
	HRAS	V-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa)
	ZMIZ1	Zinc finger, MIZ-type containing 1. (1073 aa)
	SIRT1	SIRT1 isoform 2. (751 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	ATM	ENSPTRP00000072918	ENSPTRP00000054216	Tyrosine-protein kinase.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.940
ABL1	CALR	ENSPTRP00000072918	ENSPTRP00000018010	Tyrosine-protein kinase.	Calreticulin.	0.417
ABL1	CDK2	ENSPTRP00000072918	ENSPTRP00000067097	Tyrosine-protein kinase.	CDK2 isoform 4; Belongs to the protein kinase superfamily.	0.467
ABL1	CDKN1A	ENSPTRP00000072918	ENSPTRP00000060292	Tyrosine-protein kinase.	Cyclin-dependent kinase inhibitor 1A (P21, Cip1).	0.701
ABL1	CDKN1B	ENSPTRP00000072918	ENSPTRP00000008044	Tyrosine-protein kinase.	Cyclin-dependent kinase inhibitor 1B (P27, Kip1).	0.545
ABL1	HRAS	ENSPTRP00000072918	ENSPTRP00000005495	Tyrosine-protein kinase.	V-Ha-ras Harvey rat sarcoma viral oncogene homolog.	0.567
ABL1	MAPK11	ENSPTRP00000072918	ENSPTRP00000074484	Tyrosine-protein kinase.	Mitogen-activated protein kinase.	0.421
ABL1	MAPK14	ENSPTRP00000072918	ENSPTRP00000030915	Tyrosine-protein kinase.	Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...]	0.438
ABL1	TP53	ENSPTRP00000072918	ENSPTRP00000014836	Tyrosine-protein kinase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.643
ARNTL	SIRT1	ENSPTRP00000066426	ENSPTRP00000004394	Aryl hydrocarbon receptor nuclear translocator-like.	SIRT1 isoform 2.	0.864
ARNTL	SIRT1-2	ENSPTRP00000066426	ENSPTRP00000093057	Aryl hydrocarbon receptor nuclear translocator-like.	Sirtuin 1.	0.864
ATM	ABL1	ENSPTRP00000054216	ENSPTRP00000072918	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Tyrosine-protein kinase.	0.940
ATM	BRCA2	ENSPTRP00000054216	ENSPTRP00000009812	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Breast cancer 2, early onset.	0.983
ATM	CDK2	ENSPTRP00000054216	ENSPTRP00000067097	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	CDK2 isoform 4; Belongs to the protein kinase superfamily.	0.949
ATM	CDKN1A	ENSPTRP00000054216	ENSPTRP00000060292	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cyclin-dependent kinase inhibitor 1A (P21, Cip1).	0.651
ATM	CDKN1B	ENSPTRP00000054216	ENSPTRP00000008044	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cyclin-dependent kinase inhibitor 1B (P27, Kip1).	0.541
ATM	CDKN2A	ENSPTRP00000054216	ENSPTRP00000076891	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cyclin-dependent kinase inhibitor 2A (Melanoma, p16, inhibits CDK4).	0.471
ATM	CDKN2B	ENSPTRP00000054216	ENSPTRP00000082876	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cyclin-dependent kinase inhibitor 2B (P15, inhibits CDK4).	0.460
ATM	CK820_G0012168	ENSPTRP00000054216	ENSPTRP00000061635	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	ABL1 isoform 3.	0.927
ATM	H2AFX	ENSPTRP00000054216	ENSPTRP00000007487	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	H2AFX isoform 1.	0.981