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| | PERP | P53 apoptosis effector related to PMP22. (193 aa) |
| | RPS27L | 40S ribosomal protein S27. (100 aa) |
| | BAX | BAX isoform 7. (123 aa) |
| | SIRT1-2 | Sirtuin 1. (751 aa) |
| | BAD | Bcl2-associated agonist of cell death. (168 aa) |
| | ENSPTRP00000078729 | annotation not available (160 aa) |
| | CUL4A-2 | Cullin 4A. (763 aa) |
| | CHAC1 | Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (264 aa) |
| | HIC1 | HIC ZBTB transcriptional repressor 1. (733 aa) |
| | ERN1 | Endoplasmic reticulum to nucleus signaling 1. (977 aa) |
| | LOC107968591 | CD24 isoform 1. (80 aa) |
| | CASP6 | Caspase 6, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (293 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (391 aa) |
| | ENSPTRP00000081714 | annotation not available (310 aa) |
| | CD24 | CD24 isoform 8. (129 aa) |
| | JAK2 | Tyrosine-protein kinase. (1143 aa) |
| | ENSPTRP00000082515 | annotation not available (336 aa) |
| | ZNF385B | Zinc finger protein 385B. (471 aa) |
| | SHISA5 | Shisa family member 5. (248 aa) |
| | ATP2A1 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1068 aa) |
| | FNIP2 | Folliculin interacting protein 2. (1167 aa) |
| | BBC3-2 | BCL2 binding component 3. (270 aa) |
| | PHLDA3 | Pleckstrin homology like domain family A member 3. (127 aa) |
| | BCL2A1 | BCL2-related protein A1. (196 aa) |
| | CEBPB | CCAAT/enhancer-binding protein. (347 aa) |
| | CUL1-2 | Cullin 1. (776 aa) |
| | ENSPTRP00000086525 | annotation not available (336 aa) |
| | BDKRB2 | B2 bradykinin receptor isoform X1. (391 aa) |
| | ENSPTRP00000087425 | annotation not available (336 aa) |
| | ENSPTRP00000078515 | annotation not available (198 aa) |
| | PRODH | Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (268 aa) |
| | CK820_G0026810 | HINT1 isoform 5. (160 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa) |
| | BCL2L11 | Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa) |
| | BBC3 | BCL2 binding component 3. (270 aa) |
| | FLCN | T0180863 isoform 1. (579 aa) |
| | IKBKE | Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon. (716 aa) |
| | ERO1A | Endoplasmic reticulum oxidoreductase 1 alpha. (468 aa) |
| | CASP7 | CASP7 isoform 1; Belongs to the peptidase C14A family. (388 aa) |
| | SCN2A | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2005 aa) |
| | HTRA2 | HtrA serine peptidase 2. (458 aa) |
| | NOL3 | Nucleolar protein 3. (219 aa) |
| | ABL1 | Tyrosine-protein kinase. (1149 aa) |
| | TNFRSF10B | TNF receptor superfamily member 10b. (439 aa) |
| | CASP2-2 | Caspase 2. (452 aa) |
| | DIABLO | Diablo, IAP-binding mitochondrial protein. (239 aa) |
| | SKIL | SKI like proto-oncogene. (684 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1884 aa) |
| | AIFM1 | Apoptosis-inducing factor, mitochondrion-associated, 1. (603 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa) |
| | LOC100611078 | Cyclic AMP-dependent transcription factor ATF-4 pseudogene. (318 aa) |
| | MELK | Non-specific serine/threonine protein kinase. (651 aa) |
| | CHEK2 | Checkpoint kinase 2. (586 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (865 aa) |
| | BAG6 | BAG6 isoform 3. (1162 aa) |
| | TNFRSF1A | Tumor necrosis factor receptor superfamily, member 1A. (455 aa) |
| | DYRK2 | Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2. (601 aa) |
| | IFI16 | IFI16 isoform 4. (733 aa) |
| | PDK1 | Protein-serine/threonine kinase. (456 aa) |
| | ENSPTRP00000064916 | annotation not available (631 aa) |
| | TMBIM6 | Transmembrane BAX inhibitor motif containing 6; Belongs to the BI1 family. (291 aa) |
| | TP73 | Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (636 aa) |
| | SNW1 | SNW domain containing 1. (571 aa) |
| | MOAP1 | Modulator of apoptosis 1. (351 aa) |
| | TMEM117 | Transmembrane protein 117. (514 aa) |
| | DDX3X | DEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (733 aa) |
| | ATF2 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa) |
| | TNFRSF1B | Tumor necrosis factor receptor superfamily, member 1B. (461 aa) |
| | EPHA2 | EPH receptor A2. (976 aa) |
| | RNF186 | Ring finger protein 186. (227 aa) |
| | E2F2 | E2F transcription factor 2. (437 aa) |
| | IFI6 | Interferon alpha-inducible protein 6; Plays a role in apoptosis, negatively regulating the intrinsinc apoptotic signaling pathway and TNFSF10-induced apoptosis (By similarity). However, it has also been shown to have a pro- apoptotic activity (By similarity). May have an antiviral activity (By similarity); Belongs to the IFI6/IFI27 family. (134 aa) |
| | POU4F1 | POU domain protein. (350 aa) |
| | HIPK1 | HIPK1 isoform 10. (1210 aa) |
| | MCL1 | Myeloid cell leukemia sequence 1 (BCL2-related). (350 aa) |
| | IVNS1ABP | Influenza virus NS1A binding protein. (642 aa) |
| | ERCC6 | ERCC6 isoform 1. (1491 aa) |
| | SIRT1 | SIRT1 isoform 2. (751 aa) |
| | DDIT4 | DNA-damage-inducible transcript 4. (232 aa) |
| | BNIP3 | BCL2 interacting protein 3. (259 aa) |
| | HRAS | V-Ha-ras Harvey rat sarcoma viral oncogene homolog. (189 aa) |
| | RRP8 | Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (456 aa) |
| | TMEM109 | Transmembrane protein 109. (243 aa) |
| | LGALS12 | Galectin. (336 aa) |
| | CUL5 | CUL5 isoform 1; Belongs to the cullin family. (780 aa) |
| | PDX1 | Pancreas/duodenum homeobox protein 1; Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element [...] (283 aa) |
| | BRCA2 | Breast cancer 2, early onset. (3418 aa) |
| | CUL4A | CUL4A isoform 5; Belongs to the cullin family. (759 aa) |
| | CIDEB | Cell death inducing DFFA like effector b. (219 aa) |
| | SGPP1 | Sphingosine-1-phosphate phosphatase 1. (441 aa) |
| | GSKIP | Chromosome 14 open reading frame 129. (139 aa) |
| | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (579 aa) |
| | PPP1R13B | Protein phosphatase 1, regulatory (Inhibitor) subunit 13B. (1090 aa) |
| | SIVA1 | Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. (175 aa) |
| | ELL3 | Elongation factor RNA polymerase II-like 3. (397 aa) |
| | BCL2L10 | BCL2L10 isoform 1. (204 aa) |
| | PML | PML isoform 6. (836 aa) |
| | RRN3 | RRN3 homolog, RNA polymerase I transcription factor. (651 aa) |
| | ERN2 | ERN2 isoform 1. (926 aa) |
| | NUPR1 | Nuclear protein 1, transcriptional regulator. (82 aa) |
| | PYCARD | PYD and CARD domain containing. (195 aa) |
| | WWOX | WW domain containing oxidoreductase. (414 aa) |
| | MYBBP1A | MYB binding protein (P160) 1a. (1338 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa) |
| | ATAD5 | ATPase family AAA domain containing 5. (1844 aa) |
| | PDK2 | Protein-serine/threonine kinase. (407 aa) |
| | DDX5 | Probable ATP-dependent RNA helicase DDX5; Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre- mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 t [...] (614 aa) |
| | STK11 | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (307 aa) |
| | PPP1R15A | PPP1R15A isoform 1. (682 aa) |
| | CYP1B1 | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (543 aa) |
| | MSH6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1360 aa) |
| | CUL3 | CUL3 isoform 2; Belongs to the cullin family. (768 aa) |
| | TRIB3 | TRIB3 isoform 4. (386 aa) |
| | BCL2L1 | BCL2L1 isoform 6. (233 aa) |
| | E2F1 | E2F transcription factor 1. (437 aa) |
| | PPM1F | PPM1F isoform 4. (454 aa) |
| | HMOX1 | Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (311 aa) |
| | ATF4 | Activating transcription factor 4 (Tax-responsive enhancer element B67). (351 aa) |
| | EP300 | E1A binding protein p300. (2175 aa) |
| | ITPR1 | ITPR1 isoform 3. (2700 aa) |
| | MLH1 | MutL homolog 1, colon cancer, nonpolyposis type 2. (756 aa) |
| | PRKCD | Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa) |
| | FHIT | Bis(5'-adenosyl)-triphosphatase. (147 aa) |
| | ARL6IP5 | PRA1 family protein. (188 aa) |
| | PDCD10 | Programmed cell death 10. (212 aa) |
| | TP63 | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa) |
| | POU4F2 | POU domain protein. (406 aa) |
| | ZNF622 | Zinc finger protein 622. (476 aa) |
| | JMY | Junction mediating and regulatory protein, p53 cofactor. (988 aa) |
| | HINT1 | Histidine triad nucleotide binding protein 1. (126 aa) |
| | ENSPTRP00000031829 | annotation not available (188 aa) |
| | HIPK2 | Homeodomain interacting protein kinase 2. (1198 aa) |
| | CASP2 | Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (452 aa) |
| | CUL1 | CUL1 isoform 1; Belongs to the cullin family. (776 aa) |
| | CLU | Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (449 aa) |
| | POLB | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa) |
| | EDA2R | Ectodysplasin A2 receptor. (318 aa) |
| | QRICH1 | Glutamine-rich 1. (776 aa) |
| | CDIP1 | Chromosome 16 open reading frame 5. (208 aa) |
| | CASP4 | Caspase 4, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (377 aa) |
| | APAF1 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa) |
| | MAP3K5 | Mitogen-activated protein kinase kinase kinase 5. (1374 aa) |
| | ATP2A3 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1052 aa) |
| | DDIT3 | DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (192 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic polypeptide; Belongs to the PI3/PI4-kinase family. (4128 aa) |
| | STK25 | Serine/threonine kinase 25. (426 aa) |
| | CASP12 | CASP12 isoform 1; Belongs to the peptidase C14A family. (341 aa) |
| | BCL3 | BCL3 transcription coactivator. (454 aa) |
| | TOPORS | Topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase. (1045 aa) |
| | BAK1 | BCL2-antagonist/killer 1. (211 aa) |
| | AEN | Apoptosis enhancing nuclease. (325 aa) |
| | MAEL | Maelstrom spermatogenic transposon silencer. (434 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa) |
| | STK24 | Serine/threonine kinase 24. (443 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa) |
| | CASP3 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (277 aa) |
| | CRIP1 | Cysteine-rich protein 1 (Intestinal). (77 aa) |
| | DAB2IP | DAB2 interacting protein. (1189 aa) |
| | SFN | SFN isoform 1; Belongs to the 14-3-3 family. (248 aa) |
| | USP47 | Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1375 aa) |
| | LOC100614689 | BCL2-related ovarian killer. (207 aa) |
| | CDKN1A | Cyclin-dependent kinase inhibitor 1A (P21, Cip1). (276 aa) |
| | SELENOK | SELENOK isoform 1. (93 aa) |
| | CK820_G0012168 | ABL1 isoform 3. (1149 aa) |
| | ENSPTRP00000062206 | annotation not available (69 aa) |
| | NOX1 | NADPH oxidase 1. (564 aa) |
| | CUL2 | CUL2 isoform 8; Belongs to the cullin family. (764 aa) |
| | ENSPTRP00000087838 | annotation not available (82 aa) |
| | ENSPTRP00000088116 | annotation not available (384 aa) |
| | DNAJC10 | DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. (822 aa) |
| | COA8 | Apoptogenic protein 1, mitochondrial isoform X1. (206 aa) |
| | TP53BP2 | Tumor protein p53 binding protein 2. (1137 aa) |
| | USP28 | USP28 isoform 2; Belongs to the peptidase C19 family. (1192 aa) |
| | CUL2-2 | Cullin 2. (764 aa) |
| | NFATC4 | Nuclear factor of activated T cells 4. (933 aa) |
| | CASP9 | CASP9 isoform 4; Belongs to the peptidase C14A family. (421 aa) |
| | CK820_G0024820 | PPP2R5C isoform 26. (479 aa) |
| | IFI6-2 | Interferon alpha inducible protein 6. (134 aa) |
| | BCL2 | BCL2 apoptosis regulator. (239 aa) |
| | E2F1-2 | E2F transcription factor 1. (437 aa) |
| | BRSK2 | BRSK2 isoform 5. (714 aa) |
