22 items (Pan troglodytes) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

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Your Input:
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (551 aa)
	NLRP6	NLR family pyrin domain containing 6. (892 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
	PAWR	PRKC, apoptosis, WT1, regulator. (340 aa)
	CIDEB	Cell death inducing DFFA like effector b. (219 aa)
	LGMN	LGMN isoform 1. (433 aa)
	PYCARD	PYD and CARD domain containing. (195 aa)
	CASP8	Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (538 aa)
	TBC1D10A	TBC1 domain family, member 10A. (508 aa)
	ENSPTRP00000031829	annotation not available (188 aa)
	NLRC4	NLR family CARD domain containing 4. (1024 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
	BAK1	BCL2-antagonist/killer 1. (211 aa)
	BAD	Bcl2-associated agonist of cell death. (168 aa)
	ASPH	ASPH isoform 1. (762 aa)
	CYFIP2	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1278 aa)
	IFI16	IFI16 isoform 4. (733 aa)
	PERP	P53 apoptosis effector related to PMP22. (193 aa)
	ENSPTRP00000073361	annotation not available (388 aa)
	ENSPTRP00000078515	annotation not available (198 aa)
	CASP6	Caspase 6, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (293 aa)
	CASP9	CASP9 isoform 4; Belongs to the peptidase C14A family. (421 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APAF1	BAK1	ENSPTRP00000042795	ENSPTRP00000050271	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2-antagonist/killer 1.	0.642
APAF1	CASP6	ENSPTRP00000042795	ENSPTRP00000080795	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 6, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.838
APAF1	CASP8	ENSPTRP00000042795	ENSPTRP00000021879	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.914
APAF1	CASP9	ENSPTRP00000042795	ENSPTRP00000089496	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	CASP9 isoform 4; Belongs to the peptidase C14A family.	0.999
APAF1	ENSPTRP00000078515	ENSPTRP00000042795	ENSPTRP00000078515	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	annotation not available	0.642
APAF1	FADD	ENSPTRP00000042795	ENSPTRP00000006883	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.670
APAF1	NLRC4	ENSPTRP00000042795	ENSPTRP00000041889	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	NLR family CARD domain containing 4.	0.586
APAF1	PYCARD	ENSPTRP00000042795	ENSPTRP00000013732	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	PYD and CARD domain containing.	0.457
APAF1	RIPK2	ENSPTRP00000042795	ENSPTRP00000069317	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.503
BAD	BAK1	ENSPTRP00000093875	ENSPTRP00000050271	Bcl2-associated agonist of cell death.	BCL2-antagonist/killer 1.	0.741
BAD	ENSPTRP00000078515	ENSPTRP00000093875	ENSPTRP00000078515	Bcl2-associated agonist of cell death.	annotation not available	0.741
BAK1	APAF1	ENSPTRP00000050271	ENSPTRP00000042795	BCL2-antagonist/killer 1.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.642
BAK1	BAD	ENSPTRP00000050271	ENSPTRP00000093875	BCL2-antagonist/killer 1.	Bcl2-associated agonist of cell death.	0.741
BAK1	CASP6	ENSPTRP00000050271	ENSPTRP00000080795	BCL2-antagonist/killer 1.	Caspase 6, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.479
BAK1	CASP8	ENSPTRP00000050271	ENSPTRP00000021879	BCL2-antagonist/killer 1.	Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.458
BAK1	CASP9	ENSPTRP00000050271	ENSPTRP00000089496	BCL2-antagonist/killer 1.	CASP9 isoform 4; Belongs to the peptidase C14A family.	0.507
CASP6	APAF1	ENSPTRP00000080795	ENSPTRP00000042795	Caspase 6, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.838
CASP6	BAK1	ENSPTRP00000080795	ENSPTRP00000050271	Caspase 6, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	BCL2-antagonist/killer 1.	0.479
CASP6	CASP8	ENSPTRP00000080795	ENSPTRP00000021879	Caspase 6, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.993
CASP6	CASP9	ENSPTRP00000080795	ENSPTRP00000089496	Caspase 6, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	CASP9 isoform 4; Belongs to the peptidase C14A family.	0.967