STRINGSTRING
DDX3X DDX3X IRF3 IRF3 IL6 IL6 IFNA17 IFNA17 ZC3H12A ZC3H12A IFNGR2 IFNGR2 IFNA14 IFNA14 IRF7 IRF7 VWCE VWCE IKBKE IKBKE MAPK11 MAPK11 IRGM IRGM ENSPTRP00000077294 ENSPTRP00000077294 ENSPTRP00000079495 ENSPTRP00000079495 CLPB CLPB IL6-2 IL6-2 POU2F2 POU2F2 ENSPTRP00000080822 ENSPTRP00000080822 CK820_G0014527 CK820_G0014527 WDFY4 WDFY4 JAK2 JAK2 CCL5 CCL5 CHUK CHUK IFNA8 IFNA8 LOC741747 LOC741747 POU2AF1 POU2AF1 ADAR ADAR ENSPTRP00000087328 ENSPTRP00000087328 LGALS9 LGALS9 LOC742651 LOC742651 ENSPTRP00000089473 ENSPTRP00000089473 IFI6-2 IFI6-2 SMAD3 SMAD3 MMP12 MMP12 PHB2 PHB2 IFNGR2-2 IFNGR2-2 IFNW1 IFNW1 BAX BAX RIOK3 RIOK3 ENSPTRP00000093593 ENSPTRP00000093593 IFI6 IFI6 JAK1 JAK1 ARF1 ARF1 LGALS8 LGALS8 NLRP3 NLRP3 OAS3 OAS3 HIF1A HIF1A RNF135 RNF135 DHX58 DHX58 PHB PHB CALR CALR LSM14A LSM14A IFNL3 IFNL3 IFNL1 IFNL1 TGFB1 TGFB1 IFIH1 IFIH1 IFNAR1 IFNAR1 RRP1B RRP1B TOMM70 TOMM70 IL12A IL12A CXCL10 CXCL10 NFKB1 NFKB1 IL21 IL21 TLR3 TLR3 MAPK14 MAPK14 GSDME GSDME PENK PENK EXT1 EXT1 IFNB1 IFNB1 IFNA21 IFNA21 IFNA5 IFNA5 IFNE IFNE IFNK IFNK DDX58 DDX58 CCL19 CCL19 FMR1 FMR1 GBF1 GBF1 GLI2 GLI2 IFNLR1 IFNLR1 ZC3HAV1 ZC3HAV1 IL10RB IL10RB TLR7 TLR7 TYK2 TYK2 IFNGR1 IFNGR1 OAS1 OAS1 IFNAR2 IFNAR2 IFNA6 IFNA6 ENSPTRP00000061894 ENSPTRP00000061894 ENSPTRP00000061970 ENSPTRP00000061970 ENSPTRP00000062123 ENSPTRP00000062123 IFNAR2-2 IFNAR2-2 ATF2 ATF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (733 aa)
IRF3Interferon regulatory factor 3. (452 aa)
IL6Interleukin 6 (Interferon, beta 2). (234 aa)
IFNA17IFNA17 isoform 1. (189 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (599 aa)
IFNGR2Interferon gamma receptor 2. (356 aa)
IFNA14Interferon alpha 14. (189 aa)
IRF7Interferon regulatory factor 7. (516 aa)
VWCEVon Willebrand factor C and EGF domains. (955 aa)
IKBKEInhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon. (716 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
IRGMImmunity-related GTPase M. (214 aa)
ENSPTRP00000077294annotation not available (558 aa)
ENSPTRP00000079495annotation not available (194 aa)
CLPBCLPB isoform 2. (705 aa)
IL6-2Interleukin 6. (234 aa)
POU2F2POU domain protein. (622 aa)
ENSPTRP00000080822annotation not available (404 aa)
CK820_G0014527IFNA13 isoform 2. (198 aa)
WDFY4WDFY4 isoform 2. (3184 aa)
JAK2Tyrosine-protein kinase. (1143 aa)
CCL5C-C motif chemokine. (91 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (760 aa)
IFNA8Interferon alpha 8. (189 aa)
LOC741747IFNA7 isoform 1. (189 aa)
POU2AF1POU class 2 homeobox associating factor 1. (303 aa)
ADARAdenosine deaminase, RNA-specific. (1229 aa)
ENSPTRP00000087328annotation not available (242 aa)
LGALS9Galectin. (355 aa)
LOC742651IFNA1 isoform 1. (195 aa)
ENSPTRP00000089473annotation not available (177 aa)
IFI6-2Interferon alpha inducible protein 6. (134 aa)
SMAD3Mothers against decapentaplegic homolog. (442 aa)
MMP12MMP12 isoform 1. (470 aa)
PHB2Prohibitin. (299 aa)
IFNGR2-2IFNGR2 isoform 6. (302 aa)
IFNW1IFNW1 isoform 1. (200 aa)
BAXBAX isoform 7. (123 aa)
RIOK3Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. (606 aa)
ENSPTRP00000093593annotation not available (450 aa)
IFI6Interferon alpha-inducible protein 6; Plays a role in apoptosis, negatively regulating the intrinsinc apoptotic signaling pathway and TNFSF10-induced apoptosis (By similarity). However, it has also been shown to have a pro- apoptotic activity (By similarity). May have an antiviral activity (By similarity); Belongs to the IFI6/IFI27 family. (134 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
ARF1ADP-ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family. (181 aa)
LGALS8Galectin. (359 aa)
NLRP3NLRP3 isoform 2. (1025 aa)
OAS32'-5'-oligoadenylate synthetase 3, 100kDa. (1087 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
RNF135Ring finger protein 135. (436 aa)
DHX58DEXH (Asp-Glu-X-His) box polypeptide 58. (678 aa)
PHBProhibitin. (272 aa)
CALRCalreticulin. (414 aa)
LSM14ALSM14A mRNA processing body assembly factor. (463 aa)
IFNL3IFNL3 isoform 2. (196 aa)
IFNL1Interferon lambda 1. (200 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
IFIH1IFIH1 isoform 1. (1025 aa)
IFNAR1Interferon (Alpha, beta and omega) receptor 1. (558 aa)
RRP1BRibosomal RNA processing 1 homolog B. (758 aa)
TOMM70Translocase of outer mitochondrial membrane 70 homolog A. (608 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
CXCL10C-X-C motif chemokine. (96 aa)
NFKB1Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (969 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
TLR3Toll-like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
GSDMEDeafness, autosomal dominant 5. (496 aa)
PENKPENK isoform 3. (267 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
IFNB1Interferon beta 1. (187 aa)
IFNA21Interferon alpha 21. (189 aa)
IFNA5Interferon alpha 5. (189 aa)
IFNEInterferon, epsilon. (208 aa)
IFNKIFNK isoform 1. (208 aa)
DDX58DEAD (Asp-Glu-Ala-Asp) box polypeptide 58. (925 aa)
CCL19C-C motif chemokine. (98 aa)
FMR1Fragile X mental retardation 1. (632 aa)
GBF1Golgi brefeldin A resistant guanine nucleotide exchange factor 1. (1859 aa)
GLI2GLI family zinc finger 2. (1587 aa)
IFNLR1IFNLR1 isoform 2. (521 aa)
ZC3HAV1Zinc finger CCCH-type containing, antiviral 1. (1024 aa)
IL10RBInterleukin 10 receptor, beta. (325 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
TYK2Tyrosine-protein kinase. (1184 aa)
IFNGR1Interferon gamma receptor 1. (489 aa)
OAS1Oligoadenylate synthetase 1 isoform p46. (442 aa)
IFNAR2Interferon alpha/beta receptor 2 isoform X4. (519 aa)
IFNA6Interferon alpha 6. (190 aa)
ENSPTRP00000061894annotation not available (404 aa)
ENSPTRP00000061970annotation not available (325 aa)
ENSPTRP00000062123annotation not available (256 aa)
IFNAR2-2Interferon alpha and beta receptor subunit 2. (519 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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