(80 nodes) Schaffer collateral - CA1 synapse network (Pan troglodytes)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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gene neighborhood

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protein homology

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	TNR	TNR isoform 1. (1358 aa)
	INA	Internexin neuronal intermediate filament protein, alpha; Belongs to the intermediate filament family. (499 aa)
	ADRB1	Adrenoceptor beta 1. (476 aa)
	LRRC4C	Leucine rich repeat containing 4C. (640 aa)
	STX3	STX3 isoform 2; Belongs to the syntaxin family. (290 aa)
	CHRM1	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (460 aa)
	GRM5	Glutamate metabotropic receptor 5. (1210 aa)
	GRASP	GRASP isoform 4. (394 aa)
	EFNB2	EFNB2 isoform 1; Belongs to the ephrin family. (333 aa)
	NPTN	NPTN isoform 2. (398 aa)
	CACNG3	Calcium voltage-gated channel auxiliary subunit gamma 3. (315 aa)
	ABR	Active BCR-related protein. (840 aa)
	ADORA2B	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (332 aa)
	FBXL20	F-box and leucine rich repeat protein 20. (438 aa)
	PTPRS	Protein tyrosine phosphatase receptor type S. (1948 aa)
	GIPC1	GIPC1 isoform 3. (333 aa)
	CACNG2	Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
	ITPR1	ITPR1 isoform 3. (2700 aa)
	PFN2	Profilin; Belongs to the profilin family. (188 aa)
	GHSR	Growth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
	LRRTM2	Leucine rich repeat transmembrane neuronal 2. (516 aa)
	EPHA7	EPHA7 isoform 2. (998 aa)
	GRM1	Glutamate receptor, metabotropic 1. (1194 aa)
	PLG	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (813 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
	LRRC4	Leucine rich repeat containing 4. (633 aa)
	PLAT	Plasminogen activator; Belongs to the peptidase S1 family. (649 aa)
	APBA1	Amyloid beta precursor protein binding family A member 1. (837 aa)
	SYP	SYP isoform 1. (313 aa)
	BCR	BCR activator of RhoGEF and GTPase. (1271 aa)
	CTNNB1	Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
	CASK	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (921 aa)
	PTPRD	PTPRD isoform 2. (1801 aa)
	GSG1L	GSG1L isoform 1. (331 aa)
	PTPRA	Receptor-type tyrosine-protein phosphatase alpha. (802 aa)
	ACTB	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (378 aa)
	IQSEC2	IQSEC2 isoform 1. (1446 aa)
	DGKB	Diacylglycerol kinase. (803 aa)
	P2RX3	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (397 aa)
	CPLX1	CPLX1 isoform 1. (134 aa)
	WNT7A	Protein Wnt-7a; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal [...] (349 aa)
	ENSPTRP00000064849	annotation not available (150 aa)
	BAIAP2	BAI1 associated protein 2. (553 aa)
	ADCY1-2	Adenylate cyclase 1. (1119 aa)
	SHANK1	SHANK1 isoform 3. (2161 aa)
	PRKCI	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa)
	DTNBP1	Dystrobrevin binding protein 1. (351 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (521 aa)
	DCC	DCC isoform 1. (1457 aa)
	PRKAR1B	Protein kinase cAMP-dependent type I regulatory subunit beta. (381 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (801 aa)
	ENSPTRP00000070878	annotation not available (324 aa)
	CAPZB	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (301 aa)
	LRFN2	LRFN2 isoform 1. (789 aa)
	NRXN1	NRXN1 isoform 9. (1547 aa)
	DVL1	Segment polarity protein dishevelled homolog DVL-1; Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By simi [...] (743 aa)
	GABBR1	Gamma-aminobutyric acid type B receptor subunit 1. (969 aa)
	NEFL	Neurofilament light; Belongs to the intermediate filament family. (543 aa)
	SYN1	SYN1 isoform 1. (705 aa)
	ADCY8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
	FYN	Tyrosine-protein kinase. (537 aa)
	GHRL	GHRL isoform 10. (117 aa)
	SLC30A1	Solute carrier family 30 (Zinc transporter), member 1. (507 aa)
	CK820_G0040570	PRKCZ isoform 2. (457 aa)
	ACTG1	ACTG1 isoform 13. (375 aa)
	CDK5	Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (311 aa)
	NTNG1	NTNG1 isoform 2. (540 aa)
	AKAP12	AKAP12 isoform 1. (1780 aa)
	BSN	Bassoon presynaptic cytomatrix protein. (3931 aa)
	ENSPTRP00000085189	annotation not available (1896 aa)
	EPHA4	EPH receptor A4. (986 aa)
	ENSPTRP00000086173	annotation not available (566 aa)
	CTNND1	CTNND1 isoform 23. (975 aa)
	APBA2	Amyloid beta precursor protein binding family A member 2. (751 aa)
	CK820_G0040570-2	PRKCZ isoform 4. (95 aa)
	CDH11	Cadherin 11, type 2, OB-cadherin (Osteoblast); Cadherins are calcium-dependent cell adhesion proteins. (811 aa)
	MPP2	Membrane palmitoylated protein 2; Belongs to the MAGUK family. (597 aa)
	DGKI	Diacylglycerol kinase. (1079 aa)
	SYN2	SYN2 isoform 1. (570 aa)
	NTNG2	NTNG2 isoform 1. (530 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ACTG1	ENSPTRP00000058292	ENSPTRP00000080203	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	ACTG1 isoform 13.	0.981
ACTB	CAPZB	ENSPTRP00000058292	ENSPTRP00000072044	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.894
ACTB	CTNNB1	ENSPTRP00000058292	ENSPTRP00000044466	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Catenin (Cadherin-associated protein), beta 1, 88kDa.	0.637
ACTB	ENSPTRP00000070878	ENSPTRP00000058292	ENSPTRP00000070878	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	annotation not available	0.964
ACTB	FYN	ENSPTRP00000058292	ENSPTRP00000077482	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Tyrosine-protein kinase.	0.498
ACTB	ITGB1	ENSPTRP00000058292	ENSPTRP00000069754	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Integrin beta; Belongs to the integrin beta chain family.	0.959
ACTB	PFN2	ENSPTRP00000058292	ENSPTRP00000026728	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Profilin; Belongs to the profilin family.	0.935
ACTG1	ACTB	ENSPTRP00000080203	ENSPTRP00000058292	ACTG1 isoform 13.	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	0.981
ACTG1	CAPZB	ENSPTRP00000080203	ENSPTRP00000072044	ACTG1 isoform 13.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.605
ACTG1	CTNND1	ENSPTRP00000080203	ENSPTRP00000086174	ACTG1 isoform 13.	CTNND1 isoform 23.	0.433
ACTG1	ENSPTRP00000064849	ENSPTRP00000080203	ENSPTRP00000064849	ACTG1 isoform 13.	annotation not available	0.981
ACTG1	FYN	ENSPTRP00000080203	ENSPTRP00000077482	ACTG1 isoform 13.	Tyrosine-protein kinase.	0.416
ACTG1	ITGB1	ENSPTRP00000080203	ENSPTRP00000069754	ACTG1 isoform 13.	Integrin beta; Belongs to the integrin beta chain family.	0.459
ACTG1	PFN2	ENSPTRP00000080203	ENSPTRP00000026728	ACTG1 isoform 13.	Profilin; Belongs to the profilin family.	0.464
ADCY1	ADCY8	ENSPTRP00000032741	ENSPTRP00000077396	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.944
ADCY1-2	ADCY8	ENSPTRP00000065256	ENSPTRP00000077396	Adenylate cyclase 1.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.467
ADCY8	ADCY1	ENSPTRP00000077396	ENSPTRP00000032741	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.944
ADCY8	ADCY1-2	ENSPTRP00000077396	ENSPTRP00000065256	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 1.	0.467
ADCY8	ADRB1	ENSPTRP00000077396	ENSPTRP00000005222	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adrenoceptor beta 1.	0.429
ADCY8	PRKAR1B	ENSPTRP00000077396	ENSPTRP00000069205	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-dependent type I regulatory subunit beta.	0.463