STRINGSTRING
CTNNA3 CTNNA3 CACNA1C CACNA1C PKP2 PKP2 JUP JUP DSC2 DSC2 DSG2 DSG2 TRPM4 TRPM4 BIN1 BIN1 DSP DSP CAV1 CAV1 CK820_G0042363 CK820_G0042363 RYR2 RYR2 DLG1 DLG1 ENSPTRP00000092784 ENSPTRP00000092784
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CTNNA3CTNNA3 isoform 1. (895 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
PKP2PKP2 isoform 1. (837 aa)
JUPJunction plakoglobin. (745 aa)
DSC2DSC2 isoform 1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (901 aa)
DSG2DSG2 isoform 1. (1118 aa)
TRPM4Transient receptor potential cation channel, subfamily M, member 4. (1306 aa)
BIN1Bridging integrator 1. (597 aa)
DSPDSP isoform 1. (2871 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
CK820_G0042363TRPM4 isoform 1. (1251 aa)
RYR2RYR2 isoform 1. (4941 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (926 aa)
ENSPTRP00000092784annotation not available (75 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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