STRINGSTRING
WNT11 WNT11 MTOR MTOR STMN1 STMN1 WASF2 WASF2 ENSPTRP00000000715 ENSPTRP00000000715 TACSTD2 TACSTD2 S100A10 S100A10 MYOC MYOC NRP1 NRP1 PAK1 PAK1 RAPGEF3 RAPGEF3 RGCC RGCC TGFB3 TGFB3 EVL EVL TJP1 TJP1 CGNL1 CGNL1 CORO2B CORO2B MYLK3 MYLK3 PFN1 PFN1 SMAD4 SMAD4 PIK3R2 PIK3R2 RHPN2 RHPN2 CCDC88A CCDC88A TACR1 TACR1 MKKS MKKS PPM1F PPM1F CAV3 CAV3 RHOA RHOA PFN2 PFN2 PAK2 PAK2 PTGER4 PTGER4 EDN1 EDN1 CARMIL1 CARMIL1 EPHA1 EPHA1 ARHGEF5 ARHGEF5 DLC1 DLC1 SORBS3 SORBS3 BAG4 BAG4 TESK1 TESK1 ARHGAP6 ARHGAP6 AMOT AMOT INPP5K INPP5K TPM1 TPM1 AKAP13 AKAP13 PPM1E PPM1E ARHGEF18 ARHGEF18 ARHGEF15 ARHGEF15 SYNPO SYNPO ARHGAP28 ARHGAP28 PROX1 PROX1 RHPN1 RHPN1 SFRP1 SFRP1 FHOD1 FHOD1 PHLDB2 PHLDB2 BBS4 BBS4 ANKRD23 ANKRD23 SYNPO2L SYNPO2L ARAP1 ARAP1 S1PR1 S1PR1 CK820_G0012168 CK820_G0012168 ARHGEF10L ARHGEF10L LIMCH1 LIMCH1 WNT4 WNT4 LPAR1 LPAR1 ROCK2 ROCK2 TSC1 TSC1 PPFIA1 PPFIA1 CLASP2 CLASP2 CK820_G0050308 CK820_G0050308 TTC8 TTC8 SLC9A1 SLC9A1 ASAP3 ASAP3 WAS WAS RAC1 RAC1 ENSPTRP00000070303 ENSPTRP00000070303 ENSPTRP00000070878 ENSPTRP00000070878 PXN PXN CLASP1 CLASP1 RHOC RHOC ARHGEF10 ARHGEF10 NF2 NF2 ABL1 ABL1 TGFBR1 TGFBR1 GPR65 GPR65 PXN-2 PXN-2 FRMD7 FRMD7 PIK3R1 PIK3R1 ECT2 ECT2 CDC42 CDC42 LOC472932 LOC472932 BMP10 BMP10 FRMD7-2 FRMD7-2 LIMK1-2 LIMK1-2 BRAF BRAF ACTG1 ACTG1 CD47 CD47 FERMT2 FERMT2 ENSPTRP00000081955 ENSPTRP00000081955 ITGB1BP1 ITGB1BP1 MET MET SDC4 SDC4 RAC1-2 RAC1-2 ENSPTRP00000086039 ENSPTRP00000086039 F11R F11R ENSPTRP00000088582 ENSPTRP00000088582 ALMS1 ALMS1 BRAF-2 BRAF-2 CCN2 CCN2 ENSPTRP00000090382 ENSPTRP00000090382 EPHA1-2 EPHA1-2 SMAD3 SMAD3 SERPINF2 SERPINF2 WAS-2 WAS-2 LIMK1 LIMK1 TMEFF2 TMEFF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
STMN1Stathmin; Belongs to the stathmin family. (174 aa)
WASF2WAS protein family, member 2. (498 aa)
ENSPTRP00000000715Wiskott-Aldrich syndrome protein family member 2-like. (492 aa)
TACSTD2Tumor associated calcium signal transducer 2. (324 aa)
S100A10S100 calcium binding protein A10; Belongs to the S-100 family. (97 aa)
MYOCMYOC isoform 1. (504 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
PAK1Non-specific serine/threonine protein kinase. (553 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (923 aa)
RGCCChromosome 13 open reading frame 15. (137 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
EVLEnah/Vasp-like; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (418 aa)
TJP1Tight junction protein 1; Belongs to the MAGUK family. (1748 aa)
CGNL1CGNL1 isoform 1. (1303 aa)
CORO2BCoronin; Belongs to the WD repeat coronin family. (480 aa)
MYLK3MYLK3 isoform 1. (819 aa)
PFN1Profilin; Belongs to the profilin family. (140 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
RHPN2RHPN2 isoform 2. (686 aa)
CCDC88ACoiled-coil domain containing 88A. (1870 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
MKKSMcKusick-Kaufman syndrome. (570 aa)
PPM1FPPM1F isoform 4. (454 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
RHOARas homolog family member A. (193 aa)
PFN2Profilin; Belongs to the profilin family. (188 aa)
PAK2Non-specific serine/threonine protein kinase. (476 aa)
PTGER4Prostaglandin E2 receptor EP4 subtype; Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function (By similarity). Belongs to the G-protein coupled receptor 1 family. (490 aa)
EDN1EDN1 isoform 1. (212 aa)
CARMIL1Capping protein regulator and myosin 1 linker 1. (1371 aa)
EPHA1EPH receptor A1. (976 aa)
ARHGEF5ARHGEF5 isoform 2. (1597 aa)
DLC1DLC1 Rho GTPase activating protein. (1528 aa)
SORBS3Sorbin and SH3 domain containing 3. (671 aa)
BAG4BCL2-associated athanogene 4. (457 aa)
TESK1Testis associated actin remodelling kinase 1. (626 aa)
ARHGAP6Rho GTPase activating protein 6. (974 aa)
AMOTAMOT isoform 2. (1094 aa)
INPP5KInositol polyphosphate-5-phosphatase K. (448 aa)
TPM1TPM1 isoform 3; Belongs to the tropomyosin family. (326 aa)
AKAP13A-kinase anchoring protein 13. (2813 aa)
PPM1EPPM1E isoform 1. (753 aa)
ARHGEF18Rho guanine nucleotide exchange factor 18 isoform X6. (1015 aa)
ARHGEF15ARHGEF15 isoform 3. (841 aa)
SYNPOSYNPO isoform 4. (899 aa)
ARHGAP28Rho GTPase activating protein 28. (729 aa)
PROX1Prospero homeobox 1. (737 aa)
RHPN1Rhophilin Rho GTPase binding protein 1. (670 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
FHOD1Formin homology 2 domain containing 1. (1164 aa)
PHLDB2Pleckstrin homology-like domain family B member 2 isoform X4. (1253 aa)
BBS4Bardet-Biedl syndrome 4. (519 aa)
ANKRD23Ankyrin repeat domain 23. (305 aa)
SYNPO2LSYNPO2L isoform 2. (978 aa)
ARAP1ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1. (1419 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
CK820_G0012168ABL1 isoform 3. (1149 aa)
ARHGEF10LARHGEF10L isoform 1. (1278 aa)
LIMCH1LIM and calponin homology domains 1. (1626 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
TSC1TSC complex subunit 1. (1164 aa)
PPFIA1PPFIA1 isoform 2. (1267 aa)
CLASP2CLASP2 isoform 3. (1522 aa)
CK820_G0050308T0178126 isoform 1. (382 aa)
TTC8Tetratricopeptide repeat domain 8. (531 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
ASAP3ArfGAP with SH3 domain, ankyrin repeat and PH domain 3. (905 aa)
WASWAS isoform 1. (502 aa)
RAC1Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1). (220 aa)
ENSPTRP00000070303annotation not available (117 aa)
ENSPTRP00000070878annotation not available (324 aa)
PXNPXN isoform 20. (1078 aa)
CLASP1Cytoplasmic linker associated protein 1. (1549 aa)
RHOCRho-related GTP-binding protein RhoC isoform X1. (196 aa)
ARHGEF10ARHGEF10 isoform 4. (1416 aa)
NF2Neurofibromin 2 (Merlin). (595 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
GPR65G protein-coupled receptor 65; Belongs to the G-protein coupled receptor 1 family. (337 aa)
PXN-2PXN isoform 9. (1081 aa)
FRMD7FERM domain containing 7. (594 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
ECT2Epithelial cell transforming sequence 2 oncogene. (958 aa)
CDC42Cell division cycle 42 (GTP binding protein, 25kDa). (191 aa)
LOC472932BCL2 associated athanogene 4 pseudogene. (356 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
FRMD7-2FERM domain containing 7. (714 aa)
LIMK1-2LIM domain kinase 1. (677 aa)
BRAFBRAF isoform 1; Belongs to the protein kinase superfamily. (767 aa)
ACTG1ACTG1 isoform 13. (375 aa)
CD47CD47 isoform 2. (323 aa)
FERMT2Fermitin family member 2. (706 aa)
ENSPTRP00000081955annotation not available (66 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1413 aa)
SDC4Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (198 aa)
RAC1-2Rac family small GTPase 1. (212 aa)
ENSPTRP00000086039annotation not available (570 aa)
F11RF11R isoform 1. (322 aa)
ENSPTRP00000088582annotation not available (66 aa)
ALMS1ALMS1 isoform 1. (4169 aa)
BRAF-2BRAF isoform 2. (766 aa)
CCN2CTGF isoform 1. (349 aa)
ENSPTRP00000090382annotation not available (493 aa)
EPHA1-2EPH receptor A1. (976 aa)
SMAD3Mothers against decapentaplegic homolog. (442 aa)
SERPINF2Serpin family F member 2; Belongs to the serpin family. (491 aa)
WAS-2WASP actin nucleation promoting factor. (502 aa)
LIMK1LIM domain kinase 1. (677 aa)
TMEFF2Transmembrane protein with EGF-like and two follistatin-like domains 2. (374 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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