STRINGSTRING
CD34 CD34 DKK1 DKK1 STOX1 STOX1 WNT11 WNT11 HOXC11 HOXC11 BMP4 BMP4 MESP1 MESP1 SOX8 SOX8 NGFR NGFR SOX9 SOX9 TGFB1 TGFB1 BMP2 BMP2 FGF1 FGF1 EDN1 EDN1 HOXA11 HOXA11 WNT2 WNT2 SIX4 SIX4 CTNNB1 CTNNB1 GDNF GDNF WNT2B WNT2B WNT4 WNT4 GATA3 GATA3 CSF1 CSF1 SIX1 SIX1 FGF8 FGF8 AR AR ENSPTRP00000077262 ENSPTRP00000077262 BMP4-2 BMP4-2 SPRY1 SPRY1 FGF10 FGF10 WNT5A WNT5A FRS2 FRS2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CD34CD34 isoform 1. (328 aa)
DKK1Dickkopf-like protein 1. (289 aa)
STOX1STOX1 isoform 1. (887 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
HOXC11HOXC11 isoform 1. (304 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (268 aa)
SOX8SOX8 isoform 1. (446 aa)
NGFRNerve growth factor receptor. (427 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
EDN1EDN1 isoform 1. (212 aa)
HOXA11HOXA11 isoform 2. (313 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
SIX4SIX homeobox 4. (781 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
GDNFGlial cell derived neurotrophic factor. (228 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
GATA3GATA binding protein 3. (444 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (585 aa)
SIX1SIX homeobox 1. (284 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
ARAndrogen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (912 aa)
ENSPTRP00000077262annotation not available (314 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
SPRY1Sprouty homolog 1, antagonist of FGF signaling. (319 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
FRS2Fibroblast growth factor receptor substrate 2. (521 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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