62 items (Pan troglodytes) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	TAF1	Transcription initiation factor TFIID subunit. (1927 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
	TAF12	TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa. (213 aa)
	BCL10	B-cell CLL/lymphoma 10. (316 aa)
	GTF2B	General transcription factor IIB. (310 aa)
	DR1	Down-regulator of transcription 1, TBP-binding (Negative cofactor 2). (176 aa)
	HHEX	Hematopoietically expressed homeobox. (270 aa)
	DRAP1	DR1-associated protein 1 (Negative cofactor 2 alpha). (205 aa)
	CAND1	Cullin-associated and neddylation-dissociated 1. (1230 aa)
	PSMC1	Proteasome (Prosome, macropain) 26S subunit, ATPase, 1; Belongs to the AAA ATPase family. (440 aa)
	BRF1	BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB. (658 aa)
	GTF2A2	Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (109 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
	THRA	Thyroid hormone receptor, alpha (Erythroblastic leukemia viral (V-erb-a) oncogene homolog, avian). (617 aa)
	RPTOR	Regulatory associated protein of MTOR, complex 1. (1324 aa)
	CTDP1	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (961 aa)
	GTF2F1	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (517 aa)
	THAP7	THAP domain containing 7. (309 aa)
	ATF4	Activating transcription factor 4 (Tax-responsive enhancer element B67). (351 aa)
	CAND2	Cullin associated and neddylation dissociated 2 (putative). (1236 aa)
	YEATS2	YEATS domain containing 2. (1416 aa)
	BDP1	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB. (2624 aa)
	TAF11	TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa. (211 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
	BRF2	BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like. (419 aa)
	EDF1	Endothelial differentiation related factor 1. (141 aa)
	TAF13	TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa. (124 aa)
	TCF4	Transcription factor 4. (773 aa)
	NOLC1	Nucleolar and coiled-body phosphoprotein 1. (701 aa)
	FOXF2	FOXF2 isoform 1. (444 aa)
	HNRNPF	Heterogeneous nuclear ribonucleoprotein F. (415 aa)
	RUVBL1	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
	ERCC4	Excision repair cross-complementing rodent repair deficiency, complementation group 4. (916 aa)
	RELA	V-rel reticuloendotheliosis viral oncogene homolog A (Avian). (551 aa)
	PSMC5	Proteasome (Prosome, macropain) 26S subunit, ATPase, 5; Belongs to the AAA ATPase family. (406 aa)
	TBP	TBP isoform 1. (336 aa)
	ENSPTRP00000062484	annotation not available (224 aa)
	FBL	FBL isoform 1. (336 aa)
	RUVBL2	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
	LOC736189	FBL isoform 7. (299 aa)
	ENSPTRP00000067920	annotation not available (392 aa)
	LOC100611078	Cyclic AMP-dependent transcription factor ATF-4 pseudogene. (318 aa)
	LOC470312	26S proteasome regulatory subunit 4 pseudogene. (374 aa)
	GTF2A2-2	General transcription factor IIA subunit 2. (72 aa)
	ENSPTRP00000076582	annotation not available (377 aa)
	ERCC1	ERCC excision repair 1, endonuclease non-catalytic subunit. (297 aa)
	AR	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (912 aa)
	ENSPTRP00000078721	annotation not available (91 aa)
	NOP58	NOP58 ribonucleoprotein homolog. (536 aa)
	ZNHIT6	Zinc finger, HIT-type containing 6. (470 aa)
	TAF7L	TATA-box binding protein associated factor 7 like. (457 aa)
	ZBTB43	Zinc finger and BTB domain containing 43. (467 aa)
	POLR1E	RNA polymerase I subunit E. (477 aa)
	ENSPTRP00000082515	annotation not available (336 aa)
	ENSPTRP00000083779	annotation not available (309 aa)
	HNRNPU	Heterogeneous nuclear ribonucleoprotein U (Scaffold attachment factor A). (825 aa)
	ENSPTRP00000086525	annotation not available (336 aa)
	ENSPTRP00000087425	annotation not available (336 aa)
	HSF1	Heat shock transcription factor 1. (529 aa)
	BTAF1	BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa. (1849 aa)
	GTF2A1	General transcription factor IIA, 1, 19/37kDa. (366 aa)
	ENSPTRP00000091341	annotation not available (379 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	ESR1	ENSPTRP00000076864	ENSPTRP00000031932	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.841
AR	GTF2F1	ENSPTRP00000076864	ENSPTRP00000017625	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family.	0.590
AR	MTOR	ENSPTRP00000076864	ENSPTRP00000000280	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.412
AR	RELA	ENSPTRP00000076864	ENSPTRP00000054405	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	V-rel reticuloendotheliosis viral oncogene homolog A (Avian).	0.500
AR	TAF1	ENSPTRP00000076864	ENSPTRP00000090345	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	Transcription initiation factor TFIID subunit.	0.403
AR	TP53	ENSPTRP00000076864	ENSPTRP00000014836	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.713
ATF4	ENSPTRP00000082515	ENSPTRP00000024806	ENSPTRP00000082515	Activating transcription factor 4 (Tax-responsive enhancer element B67).	annotation not available	0.545
ATF4	ENSPTRP00000086525	ENSPTRP00000024806	ENSPTRP00000086525	Activating transcription factor 4 (Tax-responsive enhancer element B67).	annotation not available	0.545
ATF4	ENSPTRP00000087425	ENSPTRP00000024806	ENSPTRP00000087425	Activating transcription factor 4 (Tax-responsive enhancer element B67).	annotation not available	0.545
ATF4	LOC100611078	ENSPTRP00000024806	ENSPTRP00000069696	Activating transcription factor 4 (Tax-responsive enhancer element B67).	Cyclic AMP-dependent transcription factor ATF-4 pseudogene.	0.545
BCL10	RELA	ENSPTRP00000001578	ENSPTRP00000054405	B-cell CLL/lymphoma 10.	V-rel reticuloendotheliosis viral oncogene homolog A (Avian).	0.652
BDP1	BRF1	ENSPTRP00000029057	ENSPTRP00000011599	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB.	BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB.	0.994
BDP1	BRF2	ENSPTRP00000029057	ENSPTRP00000034518	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB.	BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like.	0.994
BDP1	BTAF1	ENSPTRP00000029057	ENSPTRP00000089008	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB.	BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa.	0.653
BDP1	GTF2B	ENSPTRP00000029057	ENSPTRP00000001610	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB.	General transcription factor IIB.	0.544
BDP1	TAF1	ENSPTRP00000029057	ENSPTRP00000090345	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB.	Transcription initiation factor TFIID subunit.	0.462
BDP1	TBP	ENSPTRP00000029057	ENSPTRP00000058203	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB.	TBP isoform 1.	0.996
BDP1	TP53	ENSPTRP00000029057	ENSPTRP00000014836	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.587
BRF1	BDP1	ENSPTRP00000011599	ENSPTRP00000029057	BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB.	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB.	0.994
BRF1	BRF2	ENSPTRP00000011599	ENSPTRP00000034518	BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB.	BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like.	0.671