(23 nodes) Positive regulation of cytokine production involved in inflammatory response network (Pan troglodytes)

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Your Input:
	KPNA6	Importin subunit alpha; Functions in nuclear protein import. (554 aa)
	CARD9	Caspase recruitment domain family, member 9. (536 aa)
	CD6	CD6 isoform 1. (675 aa)
	STAT3	Signal transducer and activator of transcription. (790 aa)
	IL17RC	Interleukin 17 receptor C. (787 aa)
	IL6-2	Interleukin 6. (234 aa)
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
	IL6	Interleukin 6 (Interferon, beta 2). (234 aa)
	IL17RA	Interleukin 17 receptor A. (865 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa)
	IL17D	IL17D isoform 2. (209 aa)
	TICAM1	TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (543 aa)
	IL17F	IL17F isoform 1. (199 aa)
	IL17A	IL17A isoform 1. (155 aa)
	GPSM3	G-protein-signaling modulator 3. (160 aa)
	APPL1	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1. (709 aa)
	PLA2G3	PLA2G3 isoform 1. (509 aa)
	IL17C	IL17C isoform 2. (197 aa)
	NOD2	Nucleotide-binding oligomerization domain-containing protein 2; Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macroph [...] (1040 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (850 aa)
	CLEC7A	C-type lectin domain containing 7A. (247 aa)
	ANKRD42	Ankyrin repeat domain 42. (527 aa)
	GBP5	GBP5 isoform 2. (586 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CARD9	CLEC7A	ENSPTRP00000093913	ENSPTRP00000007983	Caspase recruitment domain family, member 9.	C-type lectin domain containing 7A.	0.817
CARD9	IL17A	ENSPTRP00000093913	ENSPTRP00000031222	Caspase recruitment domain family, member 9.	IL17A isoform 1.	0.465
CARD9	IL17RA	ENSPTRP00000093913	ENSPTRP00000064860	Caspase recruitment domain family, member 9.	Interleukin 17 receptor A.	0.425
CARD9	MYD88	ENSPTRP00000093913	ENSPTRP00000061524	Caspase recruitment domain family, member 9.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...]	0.681
CARD9	NOD2	ENSPTRP00000093913	ENSPTRP00000013836	Caspase recruitment domain family, member 9.	Nucleotide-binding oligomerization domain-containing protein 2; Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macroph [...]	0.864
CARD9	TNF	ENSPTRP00000093913	ENSPTRP00000069905	Caspase recruitment domain family, member 9.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.409
CLEC7A	CARD9	ENSPTRP00000007983	ENSPTRP00000093913	C-type lectin domain containing 7A.	Caspase recruitment domain family, member 9.	0.817
CLEC7A	IL17A	ENSPTRP00000007983	ENSPTRP00000031222	C-type lectin domain containing 7A.	IL17A isoform 1.	0.577
CLEC7A	IL6	ENSPTRP00000007983	ENSPTRP00000068252	C-type lectin domain containing 7A.	Interleukin 6 (Interferon, beta 2).	0.485
CLEC7A	IL6-2	ENSPTRP00000007983	ENSPTRP00000080270	C-type lectin domain containing 7A.	Interleukin 6.	0.485
CLEC7A	MYD88	ENSPTRP00000007983	ENSPTRP00000061524	C-type lectin domain containing 7A.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...]	0.629
CLEC7A	NOD2	ENSPTRP00000007983	ENSPTRP00000013836	C-type lectin domain containing 7A.	Nucleotide-binding oligomerization domain-containing protein 2; Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macroph [...]	0.523
CLEC7A	TNF	ENSPTRP00000007983	ENSPTRP00000069905	C-type lectin domain containing 7A.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.587
GBP5	TNF	ENSPTRP00000001620	ENSPTRP00000069905	GBP5 isoform 2.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.405
HIF1A	IL17A	ENSPTRP00000010887	ENSPTRP00000031222	Hypoxia inducible factor 1 subunit alpha.	IL17A isoform 1.	0.485
HIF1A	IL6	ENSPTRP00000010887	ENSPTRP00000068252	Hypoxia inducible factor 1 subunit alpha.	Interleukin 6 (Interferon, beta 2).	0.587
HIF1A	IL6-2	ENSPTRP00000010887	ENSPTRP00000080270	Hypoxia inducible factor 1 subunit alpha.	Interleukin 6.	0.587
HIF1A	STAT3	ENSPTRP00000010887	ENSPTRP00000091410	Hypoxia inducible factor 1 subunit alpha.	Signal transducer and activator of transcription.	0.961
HIF1A	TNF	ENSPTRP00000010887	ENSPTRP00000069905	Hypoxia inducible factor 1 subunit alpha.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.650
IL17A	CARD9	ENSPTRP00000031222	ENSPTRP00000093913	IL17A isoform 1.	Caspase recruitment domain family, member 9.	0.465