11 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MKS1	MKS transition zone complex subunit 1. (559 aa)
	CPLANE2	Ciliogenesis and planar polarity effector 2. (258 aa)
	GORAB	Golgin, RAB6-interacting. (394 aa)
	PRKACA	PRKACA isoform 7; Belongs to the protein kinase superfamily. (289 aa)
	GLI3	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
	TULP3	TULP3 isoform 3; Belongs to the TUB family. (501 aa)
	SUFU	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (519 aa)
	CDK20	Cyclin-dependent kinase 20; Belongs to the protein kinase superfamily. (376 aa)
	GPR161	GPR161 isoform 3; Belongs to the G-protein coupled receptor 1 family. (543 aa)
	ENSPTRP00000090301	annotation not available (443 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPTRP00000090301	PRKACA	ENSPTRP00000090301	ENSPTRP00000018062	annotation not available	PRKACA isoform 7; Belongs to the protein kinase superfamily.	0.830
ENSPTRP00000090301	PRKACB	ENSPTRP00000090301	ENSPTRP00000042330	annotation not available	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.767
ENSPTRP00000090301	TULP3	ENSPTRP00000090301	ENSPTRP00000067647	annotation not available	TULP3 isoform 3; Belongs to the TUB family.	0.707
GLI3	MKS1	ENSPTRP00000032656	ENSPTRP00000016039	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...]	MKS transition zone complex subunit 1.	0.438
GLI3	PRKACA	ENSPTRP00000032656	ENSPTRP00000018062	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...]	PRKACA isoform 7; Belongs to the protein kinase superfamily.	0.969
GLI3	PRKACB	ENSPTRP00000032656	ENSPTRP00000042330	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...]	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.969
GLI3	SUFU	ENSPTRP00000032656	ENSPTRP00000073892	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...]	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...]	0.997
GLI3	TULP3	ENSPTRP00000032656	ENSPTRP00000067647	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...]	TULP3 isoform 3; Belongs to the TUB family.	0.560
GPR161	PRKACA	ENSPTRP00000088450	ENSPTRP00000018062	GPR161 isoform 3; Belongs to the G-protein coupled receptor 1 family.	PRKACA isoform 7; Belongs to the protein kinase superfamily.	0.830
GPR161	PRKACB	ENSPTRP00000088450	ENSPTRP00000042330	GPR161 isoform 3; Belongs to the G-protein coupled receptor 1 family.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.767
GPR161	TULP3	ENSPTRP00000088450	ENSPTRP00000067647	GPR161 isoform 3; Belongs to the G-protein coupled receptor 1 family.	TULP3 isoform 3; Belongs to the TUB family.	0.707
MKS1	GLI3	ENSPTRP00000016039	ENSPTRP00000032656	MKS transition zone complex subunit 1.	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...]	0.438
PRKACA	ENSPTRP00000090301	ENSPTRP00000018062	ENSPTRP00000090301	PRKACA isoform 7; Belongs to the protein kinase superfamily.	annotation not available	0.830
PRKACA	GLI3	ENSPTRP00000018062	ENSPTRP00000032656	PRKACA isoform 7; Belongs to the protein kinase superfamily.	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...]	0.969
PRKACA	GPR161	ENSPTRP00000018062	ENSPTRP00000088450	PRKACA isoform 7; Belongs to the protein kinase superfamily.	GPR161 isoform 3; Belongs to the G-protein coupled receptor 1 family.	0.830
PRKACA	PRKACB	ENSPTRP00000018062	ENSPTRP00000042330	PRKACA isoform 7; Belongs to the protein kinase superfamily.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.984
PRKACA	SUFU	ENSPTRP00000018062	ENSPTRP00000073892	PRKACA isoform 7; Belongs to the protein kinase superfamily.	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...]	0.825
PRKACB	ENSPTRP00000090301	ENSPTRP00000042330	ENSPTRP00000090301	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	annotation not available	0.767
PRKACB	GLI3	ENSPTRP00000042330	ENSPTRP00000032656	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...]	0.969
PRKACB	GPR161	ENSPTRP00000042330	ENSPTRP00000088450	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	GPR161 isoform 3; Belongs to the G-protein coupled receptor 1 family.	0.767