42 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DMRTA2	DMRT like family A2. (539 aa)
	KIFAP3	Kinesin-associated protein 3. (792 aa)
	LRRK2	Leucine-rich repeat kinase 2. (2527 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (850 aa)
	CX3CL1	Chemokine (C-X3-C motif) ligand 1. (397 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
	NF1	Neurofibromin 1. (2839 aa)
	WDR62	WDR62 isoform 2. (1523 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	SIX3	SIX homeobox 3. (331 aa)
	ZNF335	Zinc finger protein 335. (1342 aa)
	TAFA1	TAFA chemokine like family member 1. (133 aa)
	VEGFC	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa)
	OTP	Orthopedia homeobox. (325 aa)
	CTNNA1	CTNNA1 isoform 21. (906 aa)
	GLI3	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
	SMO	SMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
	SMARCD3	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (483 aa)
	FZD3	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
	NOTCH1	NOTCH1 isoform 1. (2555 aa)
	SOX10	SRY-box transcription factor 10. (466 aa)
	TAFA3	TAFA chemokine like family member 3. (169 aa)
	CTNNB1	Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	ASPM	Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity). (3477 aa)
	FOXG1	FOXG1 isoform 8. (489 aa)
	CTF2	Cardiotrophin-2; May have an important role in neuronal precursor development and maturation; Belongs to the IL-6 superfamily. (207 aa)
	CX3CR1	C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (387 aa)
	KDM1A	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (876 aa)
	PAX6	PAX6 isoform 13. (436 aa)
	SMO-2	Smoothened, frizzled class receptor. (786 aa)
	DRD2	D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. (490 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (801 aa)
	ID4	Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein. (161 aa)
	NR2E1	Nuclear receptor subfamily 2 group E member 1. (422 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
	SMARCD3-2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (483 aa)
	DISC1	Disrupted in schizophrenia 1 protein isoform X1. (977 aa)
	DCT	Dopachrome tautomerase. (552 aa)
	PTN	PTN isoform 2. (172 aa)
	VAX1	Ventral anterior homeobox 1. (334 aa)
	NR2E1-2	Nuclear receptor subfamily 2 group E member 1. (385 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASPM	NF1	ENSPTRP00000051373	ENSPTRP00000015312	Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).	Neurofibromin 1.	0.435
ASPM	NR2E1	ENSPTRP00000051373	ENSPTRP00000073105	Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).	Nuclear receptor subfamily 2 group E member 1.	0.593
ASPM	NR2E1-2	ENSPTRP00000051373	ENSPTRP00000090963	Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).	Nuclear receptor subfamily 2 group E member 1.	0.593
ASPM	PAX6	ENSPTRP00000051373	ENSPTRP00000065705	Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).	PAX6 isoform 13.	0.446
ASPM	SHH	ENSPTRP00000051373	ENSPTRP00000075730	Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.667
ASPM	WDR62	ENSPTRP00000051373	ENSPTRP00000018646	Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).	WDR62 isoform 2.	0.885
ASPM	ZNF335	ENSPTRP00000051373	ENSPTRP00000023326	Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).	Zinc finger protein 335.	0.490
CTNNA1	CTNNB1	ENSPTRP00000029566	ENSPTRP00000044466	CTNNA1 isoform 21.	Catenin (Cadherin-associated protein), beta 1, 88kDa.	0.999
CTNNA1	ITGB1	ENSPTRP00000029566	ENSPTRP00000069754	CTNNA1 isoform 21.	Integrin beta; Belongs to the integrin beta chain family.	0.406
CTNNA1	TP53	ENSPTRP00000029566	ENSPTRP00000014836	CTNNA1 isoform 21.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.417
CTNNB1	CTNNA1	ENSPTRP00000044466	ENSPTRP00000029566	Catenin (Cadherin-associated protein), beta 1, 88kDa.	CTNNA1 isoform 21.	0.999
CTNNB1	FOXG1	ENSPTRP00000044466	ENSPTRP00000052740	Catenin (Cadherin-associated protein), beta 1, 88kDa.	FOXG1 isoform 8.	0.540
CTNNB1	FZD3	ENSPTRP00000044466	ENSPTRP00000034445	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.645
CTNNB1	GLI3	ENSPTRP00000044466	ENSPTRP00000032656	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...]	0.520
CTNNB1	HIF1A	ENSPTRP00000044466	ENSPTRP00000010887	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Hypoxia inducible factor 1 subunit alpha.	0.952
CTNNB1	ITGB1	ENSPTRP00000044466	ENSPTRP00000069754	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Integrin beta; Belongs to the integrin beta chain family.	0.533
CTNNB1	KDM1A	ENSPTRP00000044466	ENSPTRP00000062143	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.615
CTNNB1	LRRK2	ENSPTRP00000044466	ENSPTRP00000008254	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Leucine-rich repeat kinase 2.	0.628
CTNNB1	NF1	ENSPTRP00000044466	ENSPTRP00000015312	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Neurofibromin 1.	0.418
CTNNB1	NOTCH1	ENSPTRP00000044466	ENSPTRP00000036924	Catenin (Cadherin-associated protein), beta 1, 88kDa.	NOTCH1 isoform 1.	0.784