STRINGSTRING
MYOCD MYOCD ENSPTRP00000085831 ENSPTRP00000085831 EGR1 EGR1 SPI1 SPI1 TEAD1 TEAD1 BMP4-2 BMP4-2 FOS FOS PPARG PPARG SREBF1 SREBF1 MYC MYC ENSPTRP00000074929 ENSPTRP00000074929 SMARCA4 SMARCA4 LILRB4 LILRB4 TNF TNF ENSPTRP00000069878 ENSPTRP00000069878 ENSPTRP00000068326 ENSPTRP00000068326 ATOH8 ATOH8 GATA3 GATA3 ENSPTRP00000064416 ENSPTRP00000064416 ZNF512 ZNF512 TERT TERT KLF5 KLF5 NFIB NFIB RELA RELA GATA2 GATA2 RARA RARA PPARD PPARD REST REST KLF4 KLF4 MYB MYB SRF SRF PRL PRL NR3C1 NR3C1 TERT-2 TERT-2 SMAD1 SMAD1 GNL3 GNL3 PPARA PPARA SREBF2 SREBF2 PDGFB PDGFB ZNF512B ZNF512B BMP2 BMP2 NR1H2 NR1H2 TGFB1 TGFB1 SMAD4 SMAD4 GATA6 GATA6 SOX9 SOX9 NGFR NGFR TP53 TP53 MRTFB MRTFB SMAD6 SMAD6 YY1 YY1 HIF1A HIF1A BMP4 BMP4 FOSL1 FOSL1 BMPR1A BMPR1A TGFB2 TGFB2 IL10 IL10 MRTFA MRTFA STAT3 STAT3 SMAD3 SMAD3 NFATC4 NFATC4 WT1 WT1 NFATC3 NFATC3 ETS1 ETS1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MYOCDMYOCD isoform 2. (986 aa)
ENSPTRP00000085831annotation not available (79 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
SPI1Spi-1 proto-oncogene. (270 aa)
TEAD1TEAD1 isoform 6. (445 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
PPARGPeroxisome proliferator-activated receptor gamma isoform X2. (505 aa)
SREBF1SREBF1 isoform 6. (1177 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (454 aa)
ENSPTRP00000074929annotation not available (367 aa)
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1679 aa)
LILRB4LILRB4 isoform 7. (449 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
ENSPTRP00000069878annotation not available (125 aa)
ENSPTRP00000068326annotation not available (488 aa)
ATOH8Atonal bHLH transcription factor 8. (323 aa)
GATA3GATA binding protein 3. (444 aa)
ENSPTRP00000064416annotation not available (502 aa)
ZNF512Zinc finger protein 512. (564 aa)
TERTTelomerase reverse transcriptase. (360 aa)
KLF5Kruppel-like factor 5 (Intestinal). (457 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
RELAV-rel reticuloendotheliosis viral oncogene homolog A (Avian). (551 aa)
GATA2GATA binding protein 2. (480 aa)
RARARARA isoform 4. (624 aa)
PPARDPeroxisome proliferator-activated receptor delta. (441 aa)
RESTRE1 silencing transcription factor. (1097 aa)
KLF4Kruppel-like factor 4 (Gut). (479 aa)
MYBMYB proto-oncogene, transcription factor. (761 aa)
SRFSerum response factor (C-fos serum response element-binding transcription factor). (508 aa)
PRLPRL isoform 1. (227 aa)
NR3C1NR3C1 isoform 5. (778 aa)
TERT-2Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (762 aa)
SMAD1Mothers against decapentaplegic homolog. (469 aa)
GNL3Guanine nucleotide binding protein-like 3 (Nucleolar). (549 aa)
PPARAPeroxisome proliferator-activated receptor alpha. (467 aa)
SREBF2Sterol regulatory element binding transcription factor 2. (1142 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
ZNF512BZinc finger protein 512B. (892 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
NR1H2Nuclear receptor subfamily 1, group H, member 2. (461 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
GATA6GATA binding protein 6. (594 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
NGFRNerve growth factor receptor. (427 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
MRTFBMyocardin related transcription factor B. (1099 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
YY1YY1 transcription factor. (414 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (271 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
MRTFAMyocardin related transcription factor A. (966 aa)
STAT3Signal transducer and activator of transcription. (790 aa)
SMAD3Mothers against decapentaplegic homolog. (442 aa)
NFATC4Nuclear factor of activated T cells 4. (933 aa)
WT1WT1 transcription factor. (514 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3. (1075 aa)
ETS1ETS proto-oncogene 1, transcription factor. (485 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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