STRINGSTRING
ENSPTRP00000070902 ENSPTRP00000070902 FZD1-2 FZD1-2 FZD1 FZD1 ENSPTRP00000087425 ENSPTRP00000087425 ENSPTRP00000086525 ENSPTRP00000086525 NR4A3 NR4A3 ENSPTRP00000082515 ENSPTRP00000082515 RACK1 RACK1 OXR1-2 OXR1-2 PARK7 PARK7 LOC454204 LOC454204 OXR1 OXR1 LOC100611078 LOC100611078 GFER GFER SLC7A11 SLC7A11 TSC1 TSC1 CTNNB1 CTNNB1 NCOA7 NCOA7 REST REST NONO NONO PRKN PRKN ATF4 ATF4 FBXO7 FBXO7 MEAK7 MEAK7 HIF1A HIF1A WNT1 WNT1 IL10 IL10 PINK1 PINK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSPTRP00000070902annotation not available (168 aa)
FZD1-2Frizzled class receptor 1. (580 aa)
FZD1FZD1 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (580 aa)
ENSPTRP00000087425annotation not available (336 aa)
ENSPTRP00000086525annotation not available (336 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (637 aa)
ENSPTRP00000082515annotation not available (336 aa)
RACK1Receptor for activated C kinase 1. (321 aa)
OXR1-2Oxidation resistance 1. (198 aa)
PARK7PARK7 isoform 1. (189 aa)
LOC454204Non-POU domain-containing octamer-binding protein. (445 aa)
OXR1OXR1 isoform 3. (872 aa)
LOC100611078Cyclic AMP-dependent transcription factor ATF-4 pseudogene. (318 aa)
GFERSulfhydryl oxidase. (204 aa)
SLC7A11Solute carrier family 7, (Cationic amino acid transporter, y+ system) member 11. (515 aa)
TSC1TSC complex subunit 1. (1164 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
NCOA7Nuclear receptor coactivator 7. (942 aa)
RESTRE1 silencing transcription factor. (1097 aa)
NONOnon-POU domain containing octamer binding. (471 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
ATF4Activating transcription factor 4 (Tax-responsive enhancer element B67). (351 aa)
FBXO7F-box protein 7. (522 aa)
MEAK7MTOR associated protein, eak-7 homolog. (456 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
PINK1PTEN induced putative kinase 1. (581 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.