STRINGSTRING
CPLANE2 CPLANE2 ALX3 ALX3 PRRX1 PRRX1 TGFB2 TGFB2 NODAL NODAL CEP55 CEP55 FGFR2 FGFR2 FGF4 FGF4 MMP14 MMP14 BMP4 BMP4 MTHFD1 MTHFD1 TGFB3 TGFB3 IFT140 IFT140 TMEM107 TMEM107 NOG NOG TGFB1 TGFB1 MEGF8 MEGF8 SIX2 SIX2 INSIG2 INSIG2 DLX2 DLX2 TBX1 TBX1 SETD2 SETD2 TP63 TP63 WDR19 WDR19 EDNRA EDNRA NEUROG1 NEUROG1 MTHFD1L MTHFD1L HOXA1 HOXA1 HOXA2 HOXA2 GLI3 GLI3 INSIG1 INSIG1 RDH10 RDH10 GRHL2 GRHL2 EXT1 EXT1 COLEC10 COLEC10 SLC39A1 SLC39A1 SIX4 SIX4 CTNNB1 CTNNB1 FOXE1 FOXE1 CRKL CRKL NDST1 NDST1 TWIST1 TWIST1 NIPBL NIPBL PAX5 PAX5 FREM1 FREM1 RIC1 RIC1 FOXC2 FOXC2 LHX1 LHX1 WNT9B WNT9B S1PR2 S1PR2 SMAD2 SMAD2 LOC104003639 LOC104003639 EIF4A3 EIF4A3 FOXN3 FOXN3 ENSPTRP00000063945 ENSPTRP00000063945 TBX15 TBX15 RUNX2 RUNX2 ZIC3 ZIC3 TMEM107-2 TMEM107-2 IRX5 IRX5 TULP3 TULP3 SIX1 SIX1 ENSPTRP00000071105 ENSPTRP00000071105 TGFBR1 TGFBR1 TIFAB TIFAB RAB23 RAB23 GNA11 GNA11 TGFBR2 TGFBR2 MMP16 MMP16 DCANP1 DCANP1 FGF8 FGF8 WNT9B-2 WNT9B-2 HOXA1-2 HOXA1-2 BMP4-2 BMP4-2 MED12 MED12 TFAP2A TFAP2A ENSPTRP00000089450 ENSPTRP00000089450 SMAD3 SMAD3 IRF6 IRF6 CHST11 CHST11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CPLANE2Ciliogenesis and planar polarity effector 2. (258 aa)
ALX3ALX homeobox 3. (343 aa)
PRRX1Paired related homeobox 1. (245 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
NODALNODAL isoform 2. (347 aa)
CEP55Centrosomal protein 55kDa. (464 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
MTHFD1MTHFD1 isoform 1. (1020 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
IFT140Intraflagellar transport 140 homolog. (1471 aa)
TMEM107Transmembrane protein 107. (146 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
MEGF8Multiple EGF like domains 8. (2842 aa)
SIX2SIX homeobox 2. (291 aa)
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa)
DLX2Distal-less homeobox 2. (328 aa)
TBX1TBX1 isoform 1. (478 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2564 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
WDR19WD repeat domain 19. (1342 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
NEUROG1NEUROG1 isoform 1. (237 aa)
MTHFD1LMethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like. (805 aa)
HOXA1HOXA1 isoform 2. (335 aa)
HOXA2HOXA2 isoform 1. (376 aa)
GLI3Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (277 aa)
RDH10Retinol dehydrogenase 10 (All-trans); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
GRHL2Grainyhead like transcription factor 2. (625 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
COLEC10Collectin subfamily member 10. (277 aa)
SLC39A1Solute carrier family 39 (Zinc transporter), member 1. (324 aa)
SIX4SIX homeobox 4. (781 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
FOXE1FOXE1 isoform 1. (371 aa)
CRKLV-crk sarcoma virus CT10 oncogene homolog (Avian)-like. (303 aa)
NDST1N-deacetylase/N-sulfotransferase (Heparan glucosaminyl) 1. (882 aa)
TWIST1TWIST1 isoform 2. (163 aa)
NIPBLNipped-B protein. (2804 aa)
PAX5PAX5 isoform 1. (391 aa)
FREM1FREM1 isoform 1. (2179 aa)
RIC1RIC1 homolog, RAB6A GEF complex partner 1. (1423 aa)
FOXC2Forkhead box C2 (MFH-1, mesenchyme forkhead 1). (501 aa)
LHX1LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis (By similarity). (406 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
S1PR2Sphingosine-1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family. (353 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
LOC104003639Guanine nucleotide-binding protein G(s) subunit alpha. (245 aa)
EIF4A3Uncharacterized protein; Belongs to the DEAD box helicase family. (413 aa)
FOXN3FOXN3 isoform 2. (490 aa)
ENSPTRP00000063945annotation not available (476 aa)
TBX15T-box transcription factor 15. (602 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (569 aa)
ZIC3Zic family member 3. (466 aa)
TMEM107-2Transmembrane protein 107. (140 aa)
IRX5Iroquois homeobox 5. (483 aa)
TULP3TULP3 isoform 3; Belongs to the TUB family. (501 aa)
SIX1SIX homeobox 1. (284 aa)
ENSPTRP00000071105annotation not available (376 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
TIFABTIFAB isoform 1. (161 aa)
RAB23RAB23, member RAS oncogene family. (237 aa)
GNA11Guanine nucleotide binding protein (G protein), alpha 11 (Gq class). (359 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa)
MMP16Matrix metallopeptidase 16 (Membrane-inserted). (609 aa)
DCANP1LOW QUALITY PROTEIN: dendritic cell nuclear protein 1. (237 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
WNT9B-2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
HOXA1-2Homeobox A1. (335 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
MED12Mediator of RNA polymerase II transcription subunit 12; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifi [...] (2182 aa)
TFAP2ATranscription factor AP-2 alpha. (439 aa)
ENSPTRP00000089450annotation not available (303 aa)
SMAD3Mothers against decapentaplegic homolog. (442 aa)
IRF6Interferon regulatory factor 6. (467 aa)
CHST11Carbohydrate sulfotransferase. (352 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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