STRINGSTRING
BMP4-2 BMP4-2 FGF10 FGF10 MDK MDK PAX8 PAX8 WNT5A WNT5A BTBD7 BTBD7 PAX2 PAX2 PHB2 PHB2 LGR4 LGR4 SOX9 SOX9 TBX2 TBX2 NOG NOG ALOX12 ALOX12 SOX8 SOX8 FGF7 FGF7 BMP4 BMP4 NTN4 NTN4 WNT5B WNT5B MMRN2 MMRN2 STOX1 STOX1 AGT AGT TACSTD2 TACSTD2 PIK3CD PIK3CD EGF EGF CXCL10 CXCL10 CAV3 CAV3 LIF LIF BMP7 BMP7 HOXD13 HOXD13 SIX2 SIX2 TGFB1 TGFB1 FGF1 FGF1 FKBPL FKBPL ESR1 ESR1 WNT2 WNT2 SMO SMO SNAI2 SNAI2 SIX4 SIX4 SIRT6 SIRT6 CTNNB1 CTNNB1 GDNF GDNF RNF207 RNF207 SFRP1 SFRP1 NKD1 NKD1 WNT2B WNT2B LHX1 LHX1 ADAMTS12 ADAMTS12 CK820_G0012168 CK820_G0012168 WNT4 WNT4 ENSPTRP00000063703 ENSPTRP00000063703 GATA3 GATA3 LOC736481 LOC736481 SMO-2 SMO-2 TNF TNF SIX1 SIX1 HGF HGF ABL1 ABL1 AGTR2 AGTR2 SULF1 SULF1 FOXP1 FOXP1 SHH SHH AR AR MAGED1 MAGED1 ITGAX ITGAX
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BMP4-2Bone morphogenetic protein 4. (408 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
MDKMidkine (Neurite growth-promoting factor 2). (143 aa)
PAX8PAX8 isoform 1. (456 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
BTBD7BTB (POZ) domain containing 7. (1132 aa)
PAX2PAX2 isoform 1. (417 aa)
PHB2Prohibitin. (299 aa)
LGR4LGR4 isoform 2. (951 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
TBX2T-box transcription factor 2. (712 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (663 aa)
SOX8SOX8 isoform 1. (446 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
NTN4NTN4 isoform 3. (628 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
MMRN2MMRN2 isoform 1. (949 aa)
STOX1STOX1 isoform 1. (887 aa)
AGTAngiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. (485 aa)
TACSTD2Tumor associated calcium signal transducer 2. (324 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
CXCL10C-X-C motif chemokine. (96 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
LIFLeukemia inhibitory factor (Cholinergic differentiation factor). (202 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
HOXD13HOXD13 isoform 1. (344 aa)
SIX2SIX homeobox 2. (291 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
FKBPLFK506 binding protein like. (349 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
SMOSMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
SIX4SIX homeobox 4. (781 aa)
SIRT6SIRT6 isoform 1. (355 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
GDNFGlial cell derived neurotrophic factor. (228 aa)
RNF207Ring finger protein 207. (634 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
NKD1NKD inhibitor of WNT signaling pathway 1. (470 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
LHX1LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis (By similarity). (406 aa)
ADAMTS12ADAM metallopeptidase with thrombospondin type 1 motif 12. (1509 aa)
CK820_G0012168ABL1 isoform 3. (1149 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
ENSPTRP00000063703annotation not available (362 aa)
GATA3GATA binding protein 3. (444 aa)
LOC736481Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (400 aa)
SMO-2Smoothened, frizzled class receptor. (786 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
SIX1SIX homeobox 1. (284 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (812 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
AGTR2Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (363 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (901 aa)
FOXP1FOXP1 isoform 2. (693 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
ARAndrogen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (912 aa)
MAGED1MAGE family member D1. (834 aa)
ITGAXIntegrin subunit alpha X; Belongs to the integrin alpha chain family. (1169 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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