STRINGSTRING
CSNK1E CSNK1E NTF3 NTF3 CALCA CALCA HES1 HES1 CSNK1D CSNK1D TMEM108 TMEM108 CSTF2 CSTF2 USP8 USP8 DYNC1LI2 DYNC1LI2 ARF6 ARF6 EIF4A3 EIF4A3 ENSPTRP00000069792 ENSPTRP00000069792 NGF NGF RAPGEF1 RAPGEF1 ENSPTRP00000076429 ENSPTRP00000076429 UBE3A UBE3A NTRK2 NTRK2 RAPGEF2 RAPGEF2 SH3GL2 SH3GL2 AKT1 AKT1 CRK CRK NTRK1 NTRK1 ENSPTRP00000083809 ENSPTRP00000083809 RAP1A RAP1A BDNF BDNF ID1 ID1 WASF1 WASF1 MAGI2 MAGI2 ACAP2 ACAP2 MICALL1 MICALL1 E2F1 E2F1 KIDINS220 KIDINS220 EEF2K EEF2K TAC1 TAC1 NTRK3 NTRK3 ID1-2 ID1-2 HSPA5 HSPA5 NTF4 NTF4 NKPD1 NKPD1 KAT2A KAT2A TRPV1 TRPV1 CORO1A CORO1A CIB1 CIB1 RAB35 RAB35 CBL CBL SORT1 SORT1 ELAVL4 ELAVL4 STMN2 STMN2 CK820_G0008602 CK820_G0008602 E2F1-2 E2F1-2 EHD1 EHD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CSNK1ECasein kinase 1, epsilon; Belongs to the protein kinase superfamily. (419 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (275 aa)
CALCACalcitonin related polypeptide alpha. (141 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
CSNK1DCasein kinase 1 delta; Belongs to the protein kinase superfamily. (427 aa)
TMEM108Transmembrane protein 108. (575 aa)
CSTF2Cleavage stimulation factor subunit 2. (597 aa)
USP8Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1110 aa)
DYNC1LI2Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (497 aa)
ARF6ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
EIF4A3Uncharacterized protein; Belongs to the DEAD box helicase family. (413 aa)
ENSPTRP00000069792annotation not available (651 aa)
NGFBeta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone colla [...] (123 aa)
RAPGEF1RAPGEF1 isoform 5. (1065 aa)
ENSPTRP00000076429annotation not available (110 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (875 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
RAPGEF2RAPGEF2 isoform 2. (1701 aa)
SH3GL2SH3 domain containing GRB2 like 2, endophilin A1. (352 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
CRKV-crk sarcoma virus CT10 oncogene homolog (Avian). (304 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
ENSPTRP00000083809annotation not available (152 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (329 aa)
ID1Inhibitor of DNA binding 1, dominant negative helix-loop-helix protein. (155 aa)
WASF1Wiskott-Aldrich syndrome protein family member 1. (559 aa)
MAGI2Membrane associated guanylate kinase, WW and PDZ domain containing 2. (1283 aa)
ACAP2ArfGAP with coiled-coil, ankyrin repeat and PH domains 2. (778 aa)
MICALL1MICALL1 isoform 1. (863 aa)
E2F1E2F transcription factor 1. (437 aa)
KIDINS220Kinase D interacting substrate 220. (1771 aa)
EEF2KEukaryotic elongation factor 2 kinase. (725 aa)
TAC1TAC1 isoform 1. (134 aa)
NTRK3NT-3 growth factor receptor; Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. (864 aa)
ID1-2Inhibitor of DNA binding 1, HLH protein. (155 aa)
HSPA5Heat shock 70kDa protein 5 (Glucose-regulated protein, 78kDa); Belongs to the heat shock protein 70 family. (654 aa)
NTF4NTF4 isoform 1; Belongs to the NGF-beta family. (210 aa)
NKPD1NTPase KAP family P-loop domain containing 1. (612 aa)
KAT2AHistone acetyltransferase KAT2A isoform X1. (837 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1; Belongs to the transient receptor (TC 1.A.4) family. (850 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
CIB1Calcium and integrin binding 1. (231 aa)
RAB35RAB35, member RAS oncogene family. (201 aa)
CBLCas-Br-M (Murine) ecotropic retroviral transforming sequence. (906 aa)
SORT1SORT1 isoform 2. (831 aa)
ELAVL4ELAV-like protein; Belongs to the RRM elav family. (402 aa)
STMN2Stathmin; Belongs to the stathmin family. (221 aa)
CK820_G0008602USP8 isoform 7. (973 aa)
E2F1-2E2F transcription factor 1. (437 aa)
EHD1EH domain containing 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (548 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.