STRINGSTRING
FOXA2 FOXA2 ADAM19 ADAM19 BMP6 BMP6 FLOT1 FLOT1 PLG PLG NOTCH1 NOTCH1 WNT3A WNT3A NOTCH4 NOTCH4 AFDN AFDN FOXA1 FOXA1 PTPRU PTPRU WNT5A WNT5A EPCAM EPCAM NEXMIF NEXMIF DENND6A DENND6A SERPINF2 SERPINF2 MAD2L2 MAD2L2 RGCC RGCC TJP1 TJP1 PPM1F PPM1F
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FOXA2FOXA2 isoform 1. (464 aa)
ADAM19ADAM metallopeptidase domain 19. (918 aa)
BMP6Bone morphogenetic protein 6. (512 aa)
FLOT1Flotillin-1; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. (427 aa)
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (813 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
NOTCH4NOTCH4 isoform 3. (2006 aa)
AFDNAfadin, adherens junction formation factor. (1834 aa)
FOXA1FOXA1 isoform 1. (471 aa)
PTPRUProtein tyrosine phosphatase receptor type U. (1454 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
EPCAMEPCAM isoform 1. (338 aa)
NEXMIFNeurite extension and migration factor. (1516 aa)
DENND6AFamily with sequence similarity 116, member A. (608 aa)
SERPINF2Serpin family F member 2; Belongs to the serpin family. (491 aa)
MAD2L2MAD2 mitotic arrest deficient-like 2. (211 aa)
RGCCChromosome 13 open reading frame 15. (137 aa)
TJP1Tight junction protein 1; Belongs to the MAGUK family. (1748 aa)
PPM1FPPM1F isoform 4. (454 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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