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CSNK2A2 CSNK2A2 LOC107968084 LOC107968084 UBXN1 UBXN1 TTC36 TTC36 WNT1 WNT1 PSEN1 PSEN1 BAG5 BAG5 PML PML N4BP1 N4BP1 RPL23 RPL23 QRICH2 QRICH2 GIPC3 GIPC3 GIPC1 GIPC1 NOP53 NOP53 RPS7 RPS7 SMARCC1 SMARCC1 FHIT FHIT CAMLG CAMLG HSP90AB1 HSP90AB1 HIPK2 HIPK2 CCAR2 CCAR2 PBK PBK SVIP SVIP STYX STYX DDRGK1 DDRGK1 KLHL40 KLHL40 RPP21 RPP21 MAP1A MAP1A PABPN1L PABPN1L C16H16orf96 C16H16orf96 USP14 USP14 ENSPTRP00000055426 ENSPTRP00000055426 ENSPTRP00000062525 ENSPTRP00000062525 LOC467627 LOC467627 LOC735645 LOC735645 ENSPTRP00000063809 ENSPTRP00000063809 SDCBP SDCBP BAG6 BAG6 ENSPTRP00000066737 ENSPTRP00000066737 OGT OGT GIPC2 GIPC2 CK820_G0020652 CK820_G0020652 LOC453669 LOC453669 NOP53-2 NOP53-2 USP9X USP9X LOC459002 LOC459002 EIF3H EIF3H ENSPTRP00000070597 ENSPTRP00000070597 MTM1 MTM1 ENSPTRP00000070902 ENSPTRP00000070902 ENSPTRP00000071281 ENSPTRP00000071281 LOC739666 LOC739666 PANO1 PANO1 ENSPTRP00000072666 ENSPTRP00000072666 ENSPTRP00000073092 ENSPTRP00000073092 SUFU SUFU ENSPTRP00000074987 ENSPTRP00000074987 SHH SHH USP7 USP7 TLK2 TLK2 CDKN2A CDKN2A SGTA SGTA PARK7 PARK7 ENSPTRP00000078649 ENSPTRP00000078649 HFE HFE PDCL3 PDCL3 RYBP RYBP ENSPTRP00000083257 ENSPTRP00000083257 TAF9 TAF9 ENSPTRP00000084369 ENSPTRP00000084369 LOC735923 LOC735923 UCHL5 UCHL5 ENSPTRP00000086563 ENSPTRP00000086563 ENSPTRP00000088036 ENSPTRP00000088036 ENSPTRP00000089475 ENSPTRP00000089475 RPL11 RPL11 TAF1 TAF1 ENSPTRP00000091393 ENSPTRP00000091393 RPL5 RPL5 ENSPTRP00000091667 ENSPTRP00000091667 WAC WAC LOC461365 LOC461365
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CSNK2A2Casein kinase 2, alpha prime polypeptide; Belongs to the protein kinase superfamily. (350 aa)
LOC107968084Heat shock protein HSP 90-beta-like. (361 aa)
UBXN1UBX domain protein 1. (310 aa)
TTC36TTC36 isoform 3. (206 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
BAG5BCL2-associated athanogene 5. (488 aa)
PMLPML isoform 6. (836 aa)
N4BP1NEDD4 binding protein 1. (896 aa)
RPL23Ribosomal protein L23; Belongs to the universal ribosomal protein uL14 family. (140 aa)
QRICH2Glutamine rich 2. (1811 aa)
GIPC3GIPC PDZ domain containing family member 3. (312 aa)
GIPC1GIPC1 isoform 3. (333 aa)
NOP53Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (478 aa)
RPS740S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (194 aa)
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1. (1105 aa)
FHITBis(5'-adenosyl)-triphosphatase. (147 aa)
CAMLGCalcium signal-modulating cyclophilin ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B. (296 aa)
HSP90AB1HSP90AB1 isoform 1. (688 aa)
HIPK2Homeodomain interacting protein kinase 2. (1198 aa)
CCAR2Cell cycle and apoptosis regulator 2. (923 aa)
PBKT-lymphokine-activated killer cell-originated protein kinase. (322 aa)
SVIPSmall VCP/p97-interacting protein. (77 aa)
STYXSerine/threonine/tyrosine interacting protein. (223 aa)
DDRGK1DDRGK domain containing 1. (314 aa)
KLHL40Kelch like family member 40. (621 aa)
RPP21E3 ubiquitin-protein ligase TRIM39; E3 ubiquitin-protein ligase (By similarity). May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1 (By similarity). Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 (By similarity). Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation (By similari [...] (518 aa)
MAP1AMicrotubule associated protein 1A. (3041 aa)
PABPN1LPoly(A) binding protein nuclear 1 like, cytoplasmic. (278 aa)
C16H16orf96LOW QUALITY PROTEIN: uncharacterized protein C16orf96 homolog. (1104 aa)
USP14Ubiquitin carboxyl-terminal hydrolase 14; Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibi [...] (493 aa)
ENSPTRP00000055426annotation not available (200 aa)
ENSPTRP00000062525annotation not available (265 aa)
LOC46762760S ribosomal protein L5 pseudogene. (290 aa)
LOC73564540S ribosomal protein S7 pseudogene. (177 aa)
ENSPTRP00000063809annotation not available (177 aa)
SDCBPSyndecan binding protein. (324 aa)
BAG6BAG6 isoform 3. (1162 aa)
ENSPTRP00000066737annotation not available (186 aa)
OGTOGT isoform 6. (1057 aa)
GIPC2GIPC2 isoform 1. (315 aa)
CK820_G0020652RPL5 isoform 2. (112 aa)
LOC453669Ribosome biogenesis protein NOP53 pseudogene. (453 aa)
NOP53-2NOP53 ribosome biogenesis factor. (469 aa)
USP9XUbiquitin specific peptidase 9, X-linked; Belongs to the peptidase C19 family. (2591 aa)
LOC45900240S ribosomal protein S7 pseudogene. (189 aa)
EIF3HEukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (366 aa)
ENSPTRP00000070597annotation not available (57 aa)
MTM1MTM1 isoform 1. (745 aa)
ENSPTRP00000070902annotation not available (168 aa)
ENSPTRP00000071281annotation not available (237 aa)
LOC739666Syntenin-1-like. (289 aa)
PANO1Proapoptotic nucleolar protein 1. (215 aa)
ENSPTRP00000072666annotation not available (596 aa)
ENSPTRP00000073092annotation not available (243 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (519 aa)
ENSPTRP00000074987annotation not available (189 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1121 aa)
TLK2TLK2 isoform 4. (748 aa)
CDKN2ACyclin-dependent kinase inhibitor 2A (Melanoma, p16, inhibits CDK4). (173 aa)
SGTASmall glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha. (319 aa)
PARK7PARK7 isoform 1. (189 aa)
ENSPTRP00000078649annotation not available (188 aa)
HFEHereditary hemochromatosis protein homolog; Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin. (348 aa)
PDCL3Phosducin-like 3. (239 aa)
RYBPRYBP isoform 2. (228 aa)
ENSPTRP00000083257annotation not available (412 aa)
TAF9TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa. (255 aa)
ENSPTRP00000084369annotation not available (64 aa)
LOC735923Phosducin-like protein 3 pseudogene. (220 aa)
UCHL5Ubiquitin carboxyl-terminal hydrolase. (393 aa)
ENSPTRP00000086563annotation not available (245 aa)
ENSPTRP00000088036annotation not available (243 aa)
ENSPTRP00000089475annotation not available (268 aa)
RPL11Ribosomal protein L11; Belongs to the universal ribosomal protein uL5 family. (178 aa)
TAF1Transcription initiation factor TFIID subunit. (1927 aa)
ENSPTRP00000091393annotation not available (167 aa)
RPL5Ribosomal protein L5. (302 aa)
ENSPTRP00000091667annotation not available (191 aa)
WACWW domain containing adaptor with coiled-coil. (653 aa)
LOC461365Heat shock protein HSP 90-beta pseudogene. (584 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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