STRINGSTRING
CIP2A CIP2A DCT DCT PTN PTN ENSPTRP00000081136 ENSPTRP00000081136 SMARCA1 SMARCA1 ENSPTRP00000084126 ENSPTRP00000084126 MDK MDK LIMS2 LIMS2 WNT5A WNT5A PTBP2 PTBP2 VAX1 VAX1 ENSPTRP00000089297 ENSPTRP00000089297 RASSF10 RASSF10 NR2E1-2 NR2E1-2 LOC744219 LOC744219 CDH2 CDH2 DISC1 DISC1 GLI1 GLI1 ASCL1 ASCL1 SMARCD3-2 SMARCD3-2 SHCBP1 SHCBP1 SHH SHH NR2E1 NR2E1 NF2 NF2 ID4 ID4 ENSPTRP00000071376 ENSPTRP00000071376 DLL4 DLL4 ITGB1 ITGB1 DRD2 DRD2 CDON CDON SMO-2 SMO-2 ILK ILK NAP1L1 NAP1L1 PAX6 PAX6 KDM1A KDM1A EMX1 EMX1 CX3CR1 CX3CR1 CTF2 CTF2 ADGRG1 ADGRG1 LHX1 LHX1 GATA2 GATA2 FOXG1 FOXG1 TRIM71 TRIM71 ASPM ASPM PROX1 PROX1 WNT3A WNT3A CEND1 CEND1 FZD9 FZD9 PTPRZ1 PTPRZ1 LYN LYN CTNNB1 CTNNB1 TAFA3 TAFA3 SOX10 SOX10 SLC16A2 SLC16A2 NOTCH1 NOTCH1 LHX2 LHX2 TOX TOX FZD3 FZD3 SMARCD3 SMARCD3 SMO SMO GLI3 GLI3 CTNNA1 CTNNA1 OTP OTP VEGFC VEGFC EGF EGF TAFA1 TAFA1 GNAI2 GNAI2 RHOA RHOA ZNF335 ZNF335 LRP2 LRP2 SIX3 SIX3 ID2 ID2 CK820_G0040666 CK820_G0040666 TGFB1 TGFB1 SIRT2 SIRT2 WDR62 WDR62 NF1 NF1 SLC6A4 SLC6A4 TP53 TP53 CX3CL1 CX3CL1 ELL3 ELL3 SPINT1 SPINT1 HIF1A HIF1A FOXO1 FOXO1 KDM2B KDM2B LHX5 LHX5 APPL2 APPL2 LRRK2 LRRK2 PITX3 PITX3 GJC2 GJC2 BTG2 BTG2 GPR37L1 GPR37L1 KIFAP3 KIFAP3 NES NES DMRTA2 DMRTA2 DISP3 DISP3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CIP2ACell proliferation regulating inhibitor of protein phosphatase 2A. (906 aa)
DCTDopachrome tautomerase. (552 aa)
PTNPTN isoform 2. (172 aa)
ENSPTRP00000081136LOW QUALITY PROTEIN: uncharacterized protein LOC100614654. (148 aa)
SMARCA1SMARCA1 isoform 3. (1111 aa)
ENSPTRP00000084126annotation not available (117 aa)
MDKMidkine (Neurite growth-promoting factor 2). (143 aa)
LIMS2LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. (365 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
PTBP2Polypyrimidine tract binding protein 2. (543 aa)
VAX1Ventral anterior homeobox 1. (334 aa)
ENSPTRP00000089297annotation not available (265 aa)
RASSF10Ras association domain family member 10. (507 aa)
NR2E1-2Nuclear receptor subfamily 2 group E member 1. (385 aa)
LOC744219Nucleosome assembly protein 1-like 1 pseudogene. (339 aa)
CDH2Cadherin 2, type 1, N-cadherin (Neuronal); Cadherins are calcium-dependent cell adhesion proteins. (914 aa)
DISC1Disrupted in schizophrenia 1 protein isoform X1. (977 aa)
GLI1GLI family zinc finger 1. (1106 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (232 aa)
SMARCD3-2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (483 aa)
SHCBP1SHC binding and spindle associated 1. (672 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (422 aa)
NF2Neurofibromin 2 (Merlin). (595 aa)
ID4Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein. (161 aa)
ENSPTRP00000071376annotation not available (329 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (696 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
DRD2D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. (490 aa)
CDONCell adhesion associated, oncogene regulated. (1286 aa)
SMO-2Smoothened, frizzled class receptor. (786 aa)
ILKIntegrin-linked kinase. (533 aa)
NAP1L1Nucleosome assembly protein 1-like 1; Belongs to the nucleosome assembly protein (NAP) family. (395 aa)
PAX6PAX6 isoform 13. (436 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (876 aa)
EMX1Empty spiracles homeobox 1. (290 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (387 aa)
CTF2Cardiotrophin-2; May have an important role in neuronal precursor development and maturation; Belongs to the IL-6 superfamily. (207 aa)
ADGRG1Adhesion G-protein coupled receptor G1; Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Plays a role in the maintenance of hematopoietic stem cells a [...] (693 aa)
LHX1LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis (By similarity). (406 aa)
GATA2GATA binding protein 2. (480 aa)
FOXG1FOXG1 isoform 8. (489 aa)
TRIM71Tripartite motif containing 71. (868 aa)
ASPMAbnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity). (3477 aa)
PROX1Prospero homeobox 1. (737 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
CEND1Cell cycle exit and neuronal differentiation 1. (149 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
PTPRZ1Protein tyrosine phosphatase receptor type Z1. (2315 aa)
LYNTyrosine-protein kinase. (512 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
TAFA3TAFA chemokine like family member 3. (169 aa)
SOX10SRY-box transcription factor 10. (466 aa)
SLC16A2Solute carrier family 16, member 2 (Monocarboxylic acid transporter 8). (537 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
LHX2LHX2 isoform 1. (406 aa)
TOXThymocyte selection-associated high mobility group box. (526 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
SMARCD3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (483 aa)
SMOSMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
GLI3Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
CTNNA1CTNNA1 isoform 21. (906 aa)
OTPOrthopedia homeobox. (325 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
TAFA1TAFA chemokine like family member 1. (133 aa)
GNAI2Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2. (355 aa)
RHOARas homolog family member A. (193 aa)
ZNF335Zinc finger protein 335. (1342 aa)
LRP2LRP2 isoform 1. (4655 aa)
SIX3SIX homeobox 3. (331 aa)
ID2Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein. (134 aa)
CK820_G0040666Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (59 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
WDR62WDR62 isoform 2. (1523 aa)
NF1Neurofibromin 1. (2839 aa)
SLC6A4Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (630 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
CX3CL1Chemokine (C-X3-C motif) ligand 1. (397 aa)
ELL3Elongation factor RNA polymerase II-like 3. (397 aa)
SPINT1SPINT1 isoform 2. (529 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
FOXO1FOXO1 isoform 1. (655 aa)
KDM2BLysine (K)-specific demethylase 2B. (1336 aa)
LHX5LHX5 isoform 2. (402 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (671 aa)
LRRK2Leucine-rich repeat kinase 2. (2527 aa)
PITX3Homeobox protein. (302 aa)
GJC2Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (439 aa)
BTG2BTG anti-proliferation factor 2. (158 aa)
GPR37L1G protein-coupled receptor 37 like 1. (481 aa)
KIFAP3Kinesin-associated protein 3. (792 aa)
NESNES isoform 1; Belongs to the intermediate filament family. (1620 aa)
DMRTA2DMRT like family A2. (539 aa)
DISP3DISP3 isoform 1. (1392 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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