24 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	NR2E1-2	Nuclear receptor subfamily 2 group E member 1. (385 aa)
	KIFAP3	Kinesin-associated protein 3. (792 aa)
	BTG2	BTG anti-proliferation factor 2. (158 aa)
	APPL2	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (671 aa)
	KDM2B	Lysine (K)-specific demethylase 2B. (1336 aa)
	SPINT1	SPINT1 isoform 2. (529 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
	SLC6A4	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (630 aa)
	NF1	Neurofibromin 1. (2839 aa)
	SIRT2	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	CTNNA1	CTNNA1 isoform 21. (906 aa)
	SLC16A2	Solute carrier family 16, member 2 (Monocarboxylic acid transporter 8). (537 aa)
	CEND1	Cell cycle exit and neuronal differentiation 1. (149 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	GATA2	GATA binding protein 2. (480 aa)
	PAX6	PAX6 isoform 13. (436 aa)
	LIMS2	LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. (365 aa)
	ENSPTRP00000081136	LOW QUALITY PROTEIN: uncharacterized protein LOC100614654. (148 aa)
	PTN	PTN isoform 2. (172 aa)
	NR2E1	Nuclear receptor subfamily 2 group E member 1. (422 aa)
	ILK	Integrin-linked kinase. (533 aa)
	VAX1	Ventral anterior homeobox 1. (334 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BTG2	TP53	ENSPTRP00000003136	ENSPTRP00000014836	BTG anti-proliferation factor 2.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.784
CTNNA1	TP53	ENSPTRP00000029566	ENSPTRP00000014836	CTNNA1 isoform 21.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.417
GATA2	SLC6A4	ENSPTRP00000054198	ENSPTRP00000015294	GATA binding protein 2.	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.	0.514
GATA2	TP53	ENSPTRP00000054198	ENSPTRP00000014836	GATA binding protein 2.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.442
ILK	LIMS2	ENSPTRP00000066489	ENSPTRP00000085469	Integrin-linked kinase.	LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.	0.985
ILK	TGFB1	ENSPTRP00000066489	ENSPTRP00000018930	Integrin-linked kinase.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.430
LIMS2	ILK	ENSPTRP00000085469	ENSPTRP00000066489	LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.	Integrin-linked kinase.	0.985
NF1	PAX6	ENSPTRP00000015312	ENSPTRP00000065705	Neurofibromin 1.	PAX6 isoform 13.	0.460
NF1	TP53	ENSPTRP00000015312	ENSPTRP00000014836	Neurofibromin 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.724
NR2E1	PAX6	ENSPTRP00000073105	ENSPTRP00000065705	Nuclear receptor subfamily 2 group E member 1.	PAX6 isoform 13.	0.418
NR2E1-2	PAX6	ENSPTRP00000090963	ENSPTRP00000065705	Nuclear receptor subfamily 2 group E member 1.	PAX6 isoform 13.	0.418
PAX6	NF1	ENSPTRP00000065705	ENSPTRP00000015312	PAX6 isoform 13.	Neurofibromin 1.	0.460
PAX6	NR2E1	ENSPTRP00000065705	ENSPTRP00000073105	PAX6 isoform 13.	Nuclear receptor subfamily 2 group E member 1.	0.418
PAX6	NR2E1-2	ENSPTRP00000065705	ENSPTRP00000090963	PAX6 isoform 13.	Nuclear receptor subfamily 2 group E member 1.	0.418
PAX6	PROX1	ENSPTRP00000065705	ENSPTRP00000051173	PAX6 isoform 13.	Prospero homeobox 1.	0.478
PAX6	TP53	ENSPTRP00000065705	ENSPTRP00000014836	PAX6 isoform 13.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.486
PROX1	PAX6	ENSPTRP00000051173	ENSPTRP00000065705	Prospero homeobox 1.	PAX6 isoform 13.	0.478
SIRT2	TP53	ENSPTRP00000018763	ENSPTRP00000014836	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.632
SLC6A4	GATA2	ENSPTRP00000015294	ENSPTRP00000054198	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.	GATA binding protein 2.	0.514
TGFB1	ILK	ENSPTRP00000018930	ENSPTRP00000066489	Transforming growth factor beta; Belongs to the TGF-beta family.	Integrin-linked kinase.	0.430