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| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa) |
| | ENSPTRP00000088633 | annotation not available (430 aa) |
| | NEK7 | NIMA (Never in mitosis gene a)-related kinase 7; Belongs to the protein kinase superfamily. (302 aa) |
| | NEK2 | NIMA (Never in mitosis gene a)-related kinase 2. (445 aa) |
| | ANKRD1 | Ankyrin repeat domain 1 (Cardiac muscle). (319 aa) |
| | TNKS2 | Poly [ADP-ribose] polymerase. (1166 aa) |
| | STN1 | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (368 aa) |
| | NAT10 | RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1034 aa) |
| | MEN1 | MEN1 isoform 14. (615 aa) |
| | ING4 | Inhibitor of growth protein. (249 aa) |
| | ACVRL1 | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa) |
| | RFC5 | Replication factor C (Activator 1) 5, 36.5kDa. (340 aa) |
| | PARP4 | Poly [ADP-ribose] polymerase. (1724 aa) |
| | RFC3 | Replication factor C (Activator 1) 3, 38kDa. (356 aa) |
| | RGCC | Chromosome 13 open reading frame 15. (137 aa) |
| | DACH1 | DACH1 isoform 4. (761 aa) |
| | TINF2 | TERF1-interacting nuclear factor 2. (453 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (641 aa) |
| | PML | PML isoform 6. (836 aa) |
| | PARN | PARN isoform 1. (639 aa) |
| | CHTF8 | Chromosome transmission fidelity factor 8. (121 aa) |
| | GINS2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (184 aa) |
| | SMG6 | SMG6 isoform 2. (1419 aa) |
| | ARRB2 | ARRB2 isoform 2. (430 aa) |
| | AURKB | AURKB isoform 1; Belongs to the protein kinase superfamily. (344 aa) |
| | CTC1 | CTS telomere maintenance complex component 1. (1159 aa) |
| | KAT7 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (611 aa) |
| | POLG2 | Polymerase (DNA directed), gamma 2, accessory subunit. (485 aa) |
| | PRKD2 | Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa) |
| | CYP1B1 | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (543 aa) |
| | CCT4 | T-complex protein 1 subunit delta. (544 aa) |
| | CCT7 | T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. (543 aa) |
| | XRCC5 | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa) |
| | NPPC | Natriuretic peptide C. (126 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa) |
| | PDGFB | Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa) |
| | CCDC174 | Chromosome 3 open reading frame 19. (468 aa) |
| | PARP3 | Poly [ADP-ribose] polymerase. (539 aa) |
| | XRN1 | 5'-3' exoribonuclease 1. (1706 aa) |
| | ADIPOQ | Adiponectin, C1Q and collagen domain containing. (244 aa) |
| | HNRNPD | HNRNPD isoform 1. (356 aa) |
| | NAF1 | Nuclear assembly factor 1 ribonucleoprotein. (494 aa) |
| | CCT5 | Chaperonin containing TCP1, subunit 5 (Epsilon). (541 aa) |
| | FBXO4 | F-box protein 4. (387 aa) |
| | FGFR4 | Fibroblast growth factor receptor. (802 aa) |
| | HSP90AB1 | HSP90AB1 isoform 1. (688 aa) |
| | TCP1 | T-complex protein 1 subunit alpha. (556 aa) |
| | HNRNPA2B1 | Heterogeneous nuclear ribonucleoprotein A2/B1. (353 aa) |
| | RFC2 | Replication factor C (Activator 1) 2, 40kDa. (354 aa) |
| | PINX1 | PIN2/TERF1-interacting telomerase inhibitor 1 isoform X3. (333 aa) |
| | PTK2B | PTK2B protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa) |
| | GRHL2 | Grainyhead like transcription factor 2. (625 aa) |
| | DSCC1 | Defective in sister chromatid cohesion 1 homolog. (435 aa) |
| | KLF4 | Kruppel-like factor 4 (Gut). (479 aa) |
| | ENSPTRP00000037477 | Jade family PHD finger 3. (279 aa) |
| | RGN | Regucalcin (Senescence marker protein-30). (299 aa) |
| | DKC1 | Dyskeratosis congenita 1, dyskerin. (514 aa) |
| | SMG5 | Smg-5 homolog, nonsense mediated mRNA decay factor. (1016 aa) |
| | TENT4B | Terminal nucleotidyltransferase 4B. (700 aa) |
| | CTNNB1 | Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa) |
| | POT1 | Protection of telomeres 1 homolog. (634 aa) |
| | TERF1 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (439 aa) |
| | NOX4 | NADPH oxidase 4. (578 aa) |
| | DNAJC2 | DnaJ heat shock protein family (Hsp40) member C2. (621 aa) |
| | BMPR2 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (891 aa) |
| | NIBAN2 | FAM129B isoform 2. (746 aa) |
| | PKIB | cAMP-dependent protein kinase inhibitor; Belongs to the PKI family. (85 aa) |
| | ATR | Ataxia telangiectasia and Rad3 related; Belongs to the PI3/PI4-kinase family. (2644 aa) |
| | CCT3 | T-complex protein 1 subunit gamma. (545 aa) |
| | MAPK15 | Mitogen-activated protein kinase. (544 aa) |
| | TERF2 | Telomeric repeat binding factor 2. (542 aa) |
| | PARM1 | Prostate androgen-regulated mucin-like protein 1. (310 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa) |
| | TEN1 | Chromosome 17 open reading frame 106. (123 aa) |
| | KCNK2 | Potassium two pore domain channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (426 aa) |
| | CDKN1A | Cyclin-dependent kinase inhibitor 1A (P21, Cip1). (276 aa) |
| | CCT6A | Chaperonin containing TCP1, subunit 6A (Zeta 1). (564 aa) |
| | ENSPTRP00000061551 | annotation not available (394 aa) |
| | ENSPTRP00000062077 | annotation not available (236 aa) |
| | EXOSC10 | EXOSC10 isoform 1. (869 aa) |
| | CK820_G0011712 | POT1 isoform 12. (344 aa) |
| | DERPC | CTF8, chromosome transmission fidelity factor 8 homolog. (426 aa) |
| | MAPKAPK5 | Mitogen-activated protein kinase-activated protein kinase 5. (487 aa) |
| | ENSPTRP00000064921 | annotation not available (544 aa) |
| | ENSPTRP00000065151 | annotation not available (415 aa) |
| | PNKP | Polynucleotide kinase 3'-phosphatase. (521 aa) |
| | ENSPTRP00000065877 | annotation not available (115 aa) |
| | ENSPTRP00000067051 | annotation not available (137 aa) |
| | CHEK1 | CHEK1 isoform 10. (485 aa) |
| | JADE1 | Jade family PHD finger 1. (842 aa) |
| | RFC4 | Replication factor C (Activator 1) 4, 37kDa. (363 aa) |
| | GDF2 | GDF2 isoform 1. (429 aa) |
| | ENSPTRP00000069020 | annotation not available (380 aa) |
| | GFER | Sulfhydryl oxidase. (204 aa) |
| | DKC1-2 | Dyskerin pseudouridine synthase 1. (591 aa) |
| | ING5 | Inhibitor of growth family member 5. (254 aa) |
| | ENSPTRP00000070867 | annotation not available (447 aa) |
| | ENSPTRP00000071420 | annotation not available (392 aa) |
| | WRAP53 | WD repeat containing, antisense to TP53. (548 aa) |
| | HGF | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (812 aa) |
| | AURKB-2 | Aurora kinase B. (344 aa) |
| | MAP3K4 | MAP3K4 isoform 5. (1601 aa) |
| | RGN-2 | Regucalcin. (299 aa) |
| | MAP2K7 | Mitogen-activated protein kinase kinase 7. (438 aa) |
| | CK820_G0021068 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (341 aa) |
| | ENSPTRP00000074420 | annotation not available (260 aa) |
| | ENSPTRP00000074536 | annotation not available (520 aa) |
| | ENSPTRP00000075146 | annotation not available (457 aa) |
| | TNKS | Poly [ADP-ribose] polymerase. (1327 aa) |
| | GNL3L | Guanine nucleotide binding protein-like 3 (Nucleolar)-like. (585 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (454 aa) |
| | ENSPTRP00000075643 | Prostaglandin E synthase 3-like isoform X1. (165 aa) |
| | HMBOX1 | Homeobox containing 1. (420 aa) |
| | CCT2 | Chaperonin containing TCP1, subunit 2 (Beta). (535 aa) |
| | JADE3 | PHD finger protein 16. (823 aa) |
| | LOC743586 | T-complex protein 1 subunit alpha pseudogene. (338 aa) |
| | PPARG | Peroxisome proliferator-activated receptor gamma isoform X2. (505 aa) |
| | ENSPTRP00000076749 | annotation not available (243 aa) |
| | SRC | Tyrosine-protein kinase. (542 aa) |
| | ENSPTRP00000077287 | annotation not available (417 aa) |
| | MCRS1 | Microspherule protein 1. (475 aa) |
| | GINS3 | GINS complex subunit 3. (255 aa) |
| | PRKCQ | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (845 aa) |
| | MEAF6 | MYST/Esa1 associated factor 6. (201 aa) |
| | PDGFRB | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa) |
| | NVL | Nuclear VCP-like. (856 aa) |
| | LOC104001457 | Prostaglandin E synthase 3-like isoform X1. (160 aa) |
| | ACD | ACD isoform 1. (458 aa) |
| | GINS4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa) |
| | SMG5-2 | SMG5 nonsense mediated mRNA decay factor. (1038 aa) |
| | TFDP1 | Transcription factor. (352 aa) |
| | ENSPTRP00000082862 | annotation not available (411 aa) |
| | JADE2 | Jade family PHD finger 2. (834 aa) |
| | RFC2-2 | Replication factor C subunit 2. (354 aa) |
| | SMOC2 | SPARC related modular calcium binding 2. (398 aa) |
| | HNRNPU | Heterogeneous nuclear ribonucleoprotein U (Scaffold attachment factor A). (825 aa) |
| | ENSPTRP00000084910 | annotation not available (411 aa) |
| | ENSPTRP00000087040 | annotation not available (499 aa) |
| | ENSPTRP00000087977 | annotation not available (564 aa) |
| | GINS1 | GINS complex subunit 1 (Psf1 homolog). (196 aa) |
| | DCP2 | DCP2 decapping enzyme homolog. (420 aa) |
| | CHTF18 | CTF18, chromosome transmission fidelity factor 18 homolog. (1133 aa) |
| | SH2B1 | SH2B adaptor protein 1. (756 aa) |
| | ENSPTRP00000092193 | annotation not available (506 aa) |
| | CCT8 | Chaperonin containing TCP1, subunit 8 (Theta). (548 aa) |
| | PTGES3 | Prostaglandin E synthase 3. (164 aa) |
| | ENSPTRP00000093266 | annotation not available (417 aa) |
