STRINGSTRING
NR2E1-2 NR2E1-2 SOX11 SOX11 CCNE1 CCNE1 EPCAM EPCAM WNT5A WNT5A HNRNPU HNRNPU TBX3 TBX3 CK820_G0045089 CK820_G0045089 HMX2 HMX2 FGF10 FGF10 FERMT2 FERMT2 FGF8 FGF8 CK820_G0021068 CK820_G0021068 KDM1A KDM1A TERT TERT PBX1 PBX1 ATXN1L ATXN1L HMGA2 HMGA2 CTNNB1 CTNNB1 TIAL1 TIAL1 CITED1 CITED1 TERT-2 TERT-2 VEGFC VEGFC KDR KDR TP63 TP63 TGFB1 TGFB1 SIRT6 SIRT6 SOX9 SOX9 KAT7 KAT7 ELL3 ELL3 IRS2 IRS2 FGF9 FGF9 KITLG KITLG WNT1 WNT1 WNT10B WNT10B YAP1 YAP1 FGF4 FGF4 LTBP3 LTBP3 PTPRC PTPRC PRRX1 PRRX1 NR2E1 NR2E1 ID4 ID4 HOXA3-2 HOXA3-2 HOXA3 HOXA3 N4BP2L2 N4BP2L2 LOC736481 LOC736481 RUNX2 RUNX2 PDCD2 PDCD2 THPO THPO OSR2 OSR2 SHOX2 SHOX2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NR2E1-2Nuclear receptor subfamily 2 group E member 1. (385 aa)
SOX11Transcription factor SOX. (441 aa)
CCNE1CCNE1 isoform 1; Belongs to the cyclin family. (411 aa)
EPCAMEPCAM isoform 1. (338 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U (Scaffold attachment factor A). (825 aa)
TBX3T-box transcription factor 3. (743 aa)
CK820_G0045089RANBP3 isoform 23. (97 aa)
HMX2H6 family homeobox 2. (273 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FERMT2Fermitin family member 2. (706 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
CK820_G0021068Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (341 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (876 aa)
TERTTelomerase reverse transcriptase. (360 aa)
PBX1Pre-B-cell leukemia homeobox 1. (486 aa)
ATXN1LATXN1L isoform 2. (689 aa)
HMGA2High mobility group AT-hook 2. (147 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
TIAL1TIA1 cytotoxic granule-associated RNA binding protein-like 1. (375 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (219 aa)
TERT-2Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (762 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
SIRT6SIRT6 isoform 1. (355 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
KAT7Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (611 aa)
ELL3Elongation factor RNA polymerase II-like 3. (397 aa)
IRS2IRS2 isoform 1. (1340 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
YAP1Yes-associated protein 1. (508 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1297 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1306 aa)
PRRX1Paired related homeobox 1. (245 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (422 aa)
ID4Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein. (161 aa)
HOXA3-2Homeobox A3. (443 aa)
HOXA3HOXA3 isoform 3. (443 aa)
N4BP2L2N4BP2L2 isoform 1. (737 aa)
LOC736481Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (400 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (569 aa)
PDCD2Programmed cell death 2. (371 aa)
THPOTHPO isoform 1. (353 aa)
OSR2Protein odd-skipped-related 2 isoform X4. (433 aa)
SHOX2SHOX2 isoform 2. (343 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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