(29 nodes) Positive regulation of transcription regulatory region DNA binding network (Pan troglodytes)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

textmining

co-expression

protein homology

Your Input:
	HAND2	Heart and neural crest derivatives expressed 2. (217 aa)
	GATA3	GATA binding protein 3. (444 aa)
	ENSPTRP00000064832	annotation not available (85 aa)
	FOXC1	FOXC1 isoform 1. (550 aa)
	ENSPTRP00000065244	annotation not available (463 aa)
	PAX6	PAX6 isoform 13. (436 aa)
	IGF1	Insulin-like growth factor 1 (Somatomedin C). (196 aa)
	ENSPTRP00000070902	annotation not available (168 aa)
	IL32-2	IL32 isoform 12. (193 aa)
	ENSPTRP00000075929	annotation not available (130 aa)
	PARK7	PARK7 isoform 1. (189 aa)
	IL32	IL32 isoform 28. (225 aa)
	ENSPTRP00000085888	annotation not available (71 aa)
	POU4F1	POU domain protein. (350 aa)
	GTF2B	General transcription factor IIB. (310 aa)
	LAMTOR5	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. (173 aa)
	PARP1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (166 aa)
	RB1	RB transcriptional corepressor 1. (928 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	EP300	E1A binding protein p300. (2175 aa)
	POU4F2	POU domain protein. (406 aa)
	KLF4	Kruppel-like factor 4 (Gut). (479 aa)
	DDRGK1	DDRGK domain containing 1. (314 aa)
	CTNNB1	Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
	TWIST1	TWIST1 isoform 2. (163 aa)
	NIBAN2	FAM129B isoform 2. (746 aa)
	H1-0	H1F0 isoform 1. (194 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTNNB1	EP300	ENSPTRP00000044466	ENSPTRP00000024841	Catenin (Cadherin-associated protein), beta 1, 88kDa.	E1A binding protein p300.	0.998
CTNNB1	H1-0	ENSPTRP00000044466	ENSPTRP00000061378	Catenin (Cadherin-associated protein), beta 1, 88kDa.	H1F0 isoform 1.	0.477
CTNNB1	IFNG	ENSPTRP00000044466	ENSPTRP00000008822	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity).	0.554
CTNNB1	IGF1	ENSPTRP00000044466	ENSPTRP00000067917	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Insulin-like growth factor 1 (Somatomedin C).	0.540
CTNNB1	KLF4	ENSPTRP00000044466	ENSPTRP00000036269	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Kruppel-like factor 4 (Gut).	0.831
CTNNB1	PARP1	ENSPTRP00000044466	ENSPTRP00000003457	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.522
CTNNB1	PAX6	ENSPTRP00000044466	ENSPTRP00000065705	Catenin (Cadherin-associated protein), beta 1, 88kDa.	PAX6 isoform 13.	0.469
CTNNB1	TGFB1	ENSPTRP00000044466	ENSPTRP00000018930	Catenin (Cadherin-associated protein), beta 1, 88kDa.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.581
CTNNB1	TWIST1	ENSPTRP00000044466	ENSPTRP00000048124	Catenin (Cadherin-associated protein), beta 1, 88kDa.	TWIST1 isoform 2.	0.669
ENSPTRP00000064832	ENSPTRP00000075929	ENSPTRP00000064832	ENSPTRP00000075929	annotation not available	annotation not available	0.550
ENSPTRP00000064832	LAMTOR5	ENSPTRP00000064832	ENSPTRP00000001871	annotation not available	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5.	0.546
ENSPTRP00000070902	TRAF6	ENSPTRP00000070902	ENSPTRP00000006096	annotation not available	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.492
ENSPTRP00000075929	ENSPTRP00000064832	ENSPTRP00000075929	ENSPTRP00000064832	annotation not available	annotation not available	0.550
ENSPTRP00000075929	LAMTOR5	ENSPTRP00000075929	ENSPTRP00000001871	annotation not available	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5.	0.548
ENSPTRP00000085888	IFNG	ENSPTRP00000085888	ENSPTRP00000008822	annotation not available	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity).	0.400
EP300	CTNNB1	ENSPTRP00000024841	ENSPTRP00000044466	E1A binding protein p300.	Catenin (Cadherin-associated protein), beta 1, 88kDa.	0.998
EP300	GATA3	ENSPTRP00000024841	ENSPTRP00000064658	E1A binding protein p300.	GATA binding protein 3.	0.945
EP300	GTF2B	ENSPTRP00000024841	ENSPTRP00000001610	E1A binding protein p300.	General transcription factor IIB.	0.789
EP300	KLF4	ENSPTRP00000024841	ENSPTRP00000036269	E1A binding protein p300.	Kruppel-like factor 4 (Gut).	0.884
EP300	PARP1	ENSPTRP00000024841	ENSPTRP00000003457	E1A binding protein p300.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.808