18 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ZNF304	Zinc finger protein 304. (706 aa)
	PIK3R3	Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa)
	TLE1	Transducin-like enhancer of split 1. (814 aa)
	NOTCH1	NOTCH1 isoform 1. (2555 aa)
	SNAI2	Snail family transcriptional repressor 2. (268 aa)
	CAV1	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
	PDK4	Protein-serine/threonine kinase. (411 aa)
	BCL2L1	BCL2L1 isoform 6. (233 aa)
	PTRH2	Peptidyl-tRNA hydrolase 2. (180 aa)
	ITGA5	ITGA5 isoform 2; Belongs to the integrin alpha chain family. (1098 aa)
	MCL1	Myeloid cell leukemia sequence 1 (BCL2-related). (350 aa)
	CEACAM6	Carcinoembryonic antigen related cell adhesion molecule 5. (344 aa)
	BCL2	BCL2 apoptosis regulator. (239 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1034 aa)
	PTK2	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1113 aa)
	NTRK2	Tyrosine-protein kinase receptor. (838 aa)
	SRC	Tyrosine-protein kinase. (542 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (801 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL2	BCL2L1	ENSPTRP00000090293	ENSPTRP00000022903	BCL2 apoptosis regulator.	BCL2L1 isoform 6.	0.998
BCL2	ITGB1	ENSPTRP00000090293	ENSPTRP00000069754	BCL2 apoptosis regulator.	Integrin beta; Belongs to the integrin beta chain family.	0.492
BCL2	MCL1	ENSPTRP00000090293	ENSPTRP00000002137	BCL2 apoptosis regulator.	Myeloid cell leukemia sequence 1 (BCL2-related).	0.615
BCL2	NOTCH1	ENSPTRP00000090293	ENSPTRP00000036924	BCL2 apoptosis regulator.	NOTCH1 isoform 1.	0.569
BCL2	NTRK2	ENSPTRP00000090293	ENSPTRP00000077403	BCL2 apoptosis regulator.	Tyrosine-protein kinase receptor.	0.411
BCL2	PIK3CA	ENSPTRP00000090293	ENSPTRP00000084763	BCL2 apoptosis regulator.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.457
BCL2	PTK2	ENSPTRP00000090293	ENSPTRP00000083824	BCL2 apoptosis regulator.	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.438
BCL2	SNAI2	ENSPTRP00000090293	ENSPTRP00000034651	BCL2 apoptosis regulator.	Snail family transcriptional repressor 2.	0.457
BCL2	SRC	ENSPTRP00000090293	ENSPTRP00000076797	BCL2 apoptosis regulator.	Tyrosine-protein kinase.	0.683
BCL2	TLE1	ENSPTRP00000090293	ENSPTRP00000045296	BCL2 apoptosis regulator.	Transducin-like enhancer of split 1.	0.469
BCL2L1	BCL2	ENSPTRP00000022903	ENSPTRP00000090293	BCL2L1 isoform 6.	BCL2 apoptosis regulator.	0.998
BCL2L1	MCL1	ENSPTRP00000022903	ENSPTRP00000002137	BCL2L1 isoform 6.	Myeloid cell leukemia sequence 1 (BCL2-related).	0.796
BCL2L1	SRC	ENSPTRP00000022903	ENSPTRP00000076797	BCL2L1 isoform 6.	Tyrosine-protein kinase.	0.507
CAV1	ITGB1	ENSPTRP00000033587	ENSPTRP00000069754	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Integrin beta; Belongs to the integrin beta chain family.	0.946
CAV1	SRC	ENSPTRP00000033587	ENSPTRP00000076797	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Tyrosine-protein kinase.	0.942
ITGA5	ITGB1	ENSPTRP00000008580	ENSPTRP00000069754	ITGA5 isoform 2; Belongs to the integrin alpha chain family.	Integrin beta; Belongs to the integrin beta chain family.	0.999
ITGA5	PTK2	ENSPTRP00000008580	ENSPTRP00000083824	ITGA5 isoform 2; Belongs to the integrin alpha chain family.	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.730
ITGA5	SRC	ENSPTRP00000008580	ENSPTRP00000076797	ITGA5 isoform 2; Belongs to the integrin alpha chain family.	Tyrosine-protein kinase.	0.945
ITGB1	BCL2	ENSPTRP00000069754	ENSPTRP00000090293	Integrin beta; Belongs to the integrin beta chain family.	BCL2 apoptosis regulator.	0.492
ITGB1	CAV1	ENSPTRP00000069754	ENSPTRP00000033587	Integrin beta; Belongs to the integrin beta chain family.	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	0.946