STRINGSTRING
ZC3HC1 ZC3HC1 ARMC10 ARMC10 SERPINE1 SERPINE1 EPO EPO HSPB1 HSPB1 PRKN PRKN TNFAIP3 TNFAIP3 PHIP PHIP BMP5 BMP5 GFRAL GFRAL GCLC GCLC TMEM14A TMEM14A RIPK1 RIPK1 CTNNA1 CTNNA1 NME5 NME5 IL9 IL9 IL4 IL4 CSF2 CSF2 TERT-2 TERT-2 ING2 ING2 SH3RF1 SH3RF1 FGA FGA FGB FGB SFRP2 SFRP2 SLC25A31 SLC25A31 PF4 PF4 PARL PARL SIAH2 SIAH2 PIK3CB PIK3CB GNAI2 GNAI2 HMOX1 HMOX1 BID BID PTTG1IP PTTG1IP MMP9 MMP9 BCL2L1 BCL2L1 PAK5 PAK5 AVP AVP ACKR3 ACKR3 SCG2 SCG2 TMBIM1 TMBIM1 IL1B IL1B IL1A IL1A SLC35F6 SLC35F6 BCL2L12 BCL2L12 PIH1D1 PIH1D1 NANOS3 NANOS3 PRDX2 PRDX2 CDKN2D CDKN2D ACAA2 ACAA2 RPS6KB1 RPS6KB1 NOG NOG PCGF2 PCGF2 AATF AATF ATAD5 ATAD5 MAPK7 MAPK7 ARRB2 ARRB2 MNT MNT CX3CL1 CX3CL1 HERPUD1 HERPUD1 RRN3 RRN3 TRAP1 TRAP1 MAP2K5 MAP2K5 BCL2L10 BCL2L10 ELL3 ELL3 BAG5 BAG5 PSEN1 PSEN1 HIF1A HIF1A LGALS3 LGALS3 BMP4 BMP4 RB1 RB1 PDX1 PDX1 TRIAP1 TRIAP1 FAIM2 FAIM2 LRRK2 LRRK2 YBX3 YBX3 HYOU1 HYOU1 YAP1 YAP1 DDIAS DDIAS NDUFS3 NDUFS3 CREB3L1 CREB3L1 MAPK8IP1 MAPK8IP1 HELLS HELLS GHITM GHITM PPIF PPIF SIRT1 SIRT1 NRP1 NRP1 PTGS2 PTGS2 IVNS1ABP IVNS1ABP ENSPTRP00000088036 ENSPTRP00000088036 ENSPTRP00000088452 ENSPTRP00000088452 RAF1 RAF1 RFFL RFFL NR4A2 NR4A2 ENSPTRP00000089693 ENSPTRP00000089693 ENSPTRP00000089862 ENSPTRP00000089862 SLC25A4 SLC25A4 IFI6-2 IFI6-2 BCL2 BCL2 MIF MIF LOC473924 LOC473924 CD44 CD44 NLE1 NLE1 UNC5B UNC5B LOC466689 LOC466689 ENSPTRP00000091469 ENSPTRP00000091469 ENSPTRP00000091883 ENSPTRP00000091883 NRG1 NRG1 MAZ MAZ LOC107968189 LOC107968189 EYA2 EYA2 PRELID1 PRELID1 BAX BAX SIRT1-2 SIRT1-2 EYA4 EYA4 RTKN2 RTKN2 LMNA LMNA MUC1 MUC1 MCL1 MCL1 GNAI3 GNAI3 GCLM GCLM CTH CTH TXNDC12 TXNDC12 IFI6 IFI6 PINK1 PINK1 ENO1 ENO1 ENSPTRP00000066724 ENSPTRP00000066724 ENSPTRP00000066810 ENSPTRP00000066810 LOC748850 LOC748850 ENSPTRP00000067872 ENSPTRP00000067872 IGF1 IGF1 CXCL12 CXCL12 NDUFA13 NDUFA13 ENSPTRP00000069108 ENSPTRP00000069108 ENSPTRP00000069476 ENSPTRP00000069476 ENSPTRP00000069681 ENSPTRP00000069681 NDUFA13-2 NDUFA13-2 TNF TNF LOC736283 LOC736283 ARHGEF2 ARHGEF2 BRCA1 BRCA1 ITPRIP ITPRIP ENSPTRP00000070633 ENSPTRP00000070633 ENSPTRP00000070902 ENSPTRP00000070902 BCL2L12-2 BCL2L12-2 IL4-2 IL4-2 MEIS3 MEIS3 FAM167A FAM167A HGF HGF ENSPTRP00000072952 ENSPTRP00000072952 TGFBR1 TGFBR1 NOL3 NOL3 ENSPTRP00000073673 ENSPTRP00000073673 HTRA2 HTRA2 IL19 IL19 TPT1 TPT1 LOC454204 LOC454204 ACVR1 ACVR1 GATA4 GATA4 HDAC1 HDAC1 ENSPTRP00000076371 ENSPTRP00000076371 ENSPTRP00000076409 ENSPTRP00000076409 SRC SRC AR AR AGAP2 AGAP2 OPA1 OPA1 ENSPTRP00000077985 ENSPTRP00000077985 SYVN1 SYVN1 MPV17L MPV17L ENSPTRP00000078515 ENSPTRP00000078515 CFLAR CFLAR PARK7 PARK7 IL7 IL7 PPIA PPIA WFS1 WFS1 EPO-2 EPO-2 BMP4-2 BMP4-2 ENSPTRP00000080780 ENSPTRP00000080780 RRM2B RRM2B ENSPTRP00000081523 ENSPTRP00000081523 TCF7L2 TCF7L2 ENSPTRP00000081633 ENSPTRP00000081633 GSK3B GSK3B EYA3 EYA3 CTTN CTTN ZNF385A ZNF385A AKT1 AKT1 VDAC2 VDAC2 FGF10 FGF10 SOD2 SOD2 FGG FGG TAF9 TAF9 ICAM1 ICAM1 FXN FXN CLUL1 CLUL1 FAIM FAIM PSME3 PSME3 PELI3 PELI3 BIRC6 BIRC6 ENSPTRP00000086548 ENSPTRP00000086548 GATA1 GATA1 BDKRB2 BDKRB2 ITGA6 ITGA6 ENSPTRP00000087988 ENSPTRP00000087988 THBS1 THBS1 SNAI1 SNAI1 XBP1 XBP1 HTT HTT MARCHF7 MARCHF7 TMBIM6 TMBIM6 NFE2L2 NFE2L2 DDX3X DDX3X QARS1 QARS1 PSME3-2 PSME3-2 WNT4 WNT4 SLC25A6 SLC25A6 STRADB STRADB KDM1A KDM1A TERT TERT ZMYND11 ZMYND11 LOC471721 LOC471721 SELENOS SELENOS SLC25A5 SLC25A5 LOC745166 LOC745166 LOC735922 LOC735922 LOC100614689 LOC100614689 RNF34 RNF34 USP47 USP47 CX3CR1 CX3CR1 PLAUR PLAUR RELA RELA ITPRIPL2 ITPRIPL2 CSNK2A2 CSNK2A2 GPX1 GPX1 BAK1 BAK1 MAPK8IP2 MAPK8IP2 CREB3 CREB3 ITGAV ITGAV TMEM161A TMEM161A URI1 URI1 GDNF GDNF FZD9 FZD9 CD74 CD74 GSTP1 GSTP1 TAF9B TAF9B PEA15 PEA15 CTNNB1 CTNNB1 PTPN1 PTPN1 PSMD10 PSMD10 COL2A1 COL2A1 NOC2L NOC2L NONO NONO TRIM32 TRIM32 DNAJA1 DNAJA1 CAAP1 CAAP1 GRINA GRINA EYA1 EYA1 SGK3 SGK3 RB1CC1 RB1CC1 SNAI2 SNAI2 CLU CLU CCAR2 CCAR2 NOS3 NOS3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ZC3HC1ZC3HC1 isoform 1. (502 aa)
ARMC10ARMC10 isoform 1. (351 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (193 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (205 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
TNFAIP3Tumor necrosis factor, alpha-induced protein 3. (790 aa)
PHIPPHIP isoform 1. (1823 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
GFRALGDNF family receptor alpha like. (394 aa)
GCLCGlutamate-cysteine ligase, catalytic subunit. (637 aa)
TMEM14ATransmembrane protein 14A. (99 aa)
RIPK1Receptor (TNFRSF)-interacting serine-threonine kinase 1. (671 aa)
CTNNA1CTNNA1 isoform 21. (906 aa)
NME5NME/NM23 family member 5; Belongs to the NDK family. (212 aa)
IL9IL9 isoform 1. (144 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4. (153 aa)
CSF2Colony stimulating factor 2. (144 aa)
TERT-2Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (762 aa)
ING2Inhibitor of growth protein. (280 aa)
SH3RF1SH3 domain containing ring finger 1. (888 aa)
FGAFibrinogen alpha chain. (866 aa)
FGBFibrinogen beta chain. (491 aa)
SFRP2Secreted frizzled-related protein 2. (295 aa)
SLC25A31Solute carrier family 25 member 31; Belongs to the mitochondrial carrier (TC 2.A.29) family. (315 aa)
PF4C-X-C motif chemokine. (101 aa)
PARLAndrogen-induced gene 1 protein isoform X2. (379 aa)
SIAH2E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (324 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
GNAI2Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2. (355 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (311 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (241 aa)
PTTG1IPPituitary tumor-transforming 1 interacting protein. (180 aa)
MMP9Matrix metallopeptidase 9. (699 aa)
BCL2L1BCL2L1 isoform 6. (233 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
AVPArginine vasopressin; Belongs to the vasopressin/oxytocin family. (164 aa)
ACKR3Chemokine (C-X-C motif) receptor 7; Belongs to the G-protein coupled receptor 1 family. (362 aa)
SCG2Secretogranin II. (610 aa)
TMBIM1Transmembrane BAX inhibitor motif containing 1; Belongs to the BI1 family. (311 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (271 aa)
SLC35F6Solute carrier family 35 member F6; May play a role as a nucleotide-sugar transporter. (371 aa)
BCL2L12BCL2L12 isoform 2. (334 aa)
PIH1D1PIH1 domain containing 1. (321 aa)
NANOS3NANOS3 isoform 4; Belongs to the nanos family. (192 aa)
PRDX2PRDX2 isoform 1. (198 aa)
CDKN2DCyclin dependent kinase inhibitor 2D. (166 aa)
ACAA2Acetyl-CoA acyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
PCGF2Polycomb group ring finger 2. (344 aa)
AATFApoptosis antagonizing transcription factor. (560 aa)
ATAD5ATPase family AAA domain containing 5. (1844 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (816 aa)
ARRB2ARRB2 isoform 2. (430 aa)
MNTMAX binding protein. (582 aa)
CX3CL1Chemokine (C-X3-C motif) ligand 1. (397 aa)
HERPUD1Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1. (391 aa)
RRN3RRN3 homolog, RNA polymerase I transcription factor. (651 aa)
TRAP1TNF receptor-associated protein 1. (702 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
BCL2L10BCL2L10 isoform 1. (204 aa)
ELL3Elongation factor RNA polymerase II-like 3. (397 aa)
BAG5BCL2-associated athanogene 5. (488 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
LGALS3Galectin. (250 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
RB1RB transcriptional corepressor 1. (928 aa)
PDX1Pancreas/duodenum homeobox protein 1; Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element [...] (283 aa)
TRIAP1TP53 regulated inhibitor of apoptosis 1. (76 aa)
FAIM2FAIM2 isoform 2; Belongs to the BI1 family. (316 aa)
LRRK2Leucine-rich repeat kinase 2. (2527 aa)
YBX3Cold shock domain protein A. (374 aa)
HYOU1Hypoxia up-regulated 1. (999 aa)
YAP1Yes-associated protein 1. (508 aa)
DDIASDNA damage induced apoptosis suppressor. (998 aa)
NDUFS3NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (264 aa)
CREB3L1cAMP responsive element binding protein 3-like 1. (519 aa)
MAPK8IP1Mitogen-activated protein kinase 8 interacting protein 1. (711 aa)
HELLSHELLS isoform 4. (884 aa)
GHITMGrowth hormone inducible transmembrane protein; Belongs to the BI1 family. (345 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (207 aa)
SIRT1SIRT1 isoform 2. (751 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
PTGS2Prostaglandin-endoperoxide synthase 2 (Prostaglandin G/H synthase and cyclooxygenase). (604 aa)
IVNS1ABPInfluenza virus NS1A binding protein. (642 aa)
ENSPTRP00000088036annotation not available (243 aa)
ENSPTRP00000088452annotation not available (148 aa)
RAF1RAF1 isoform 2; Belongs to the protein kinase superfamily. (668 aa)
RFFLE3 ubiquitin-protein ligase rififylin isoform X2. (363 aa)
NR4A2Nuclear receptor subfamily 4, group A, member 2. (598 aa)
ENSPTRP00000089693annotation not available (226 aa)
ENSPTRP00000089862annotation not available (350 aa)
SLC25A4Solute carrier family 25 (Mitochondrial carrier adenine nucleotide translocator), member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
IFI6-2Interferon alpha inducible protein 6. (134 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
MIFMacrophage migration inhibitory factor. (115 aa)
LOC473924Peptidylprolyl isomerase A pseudogene. (105 aa)
CD44CD44 isoform 3. (742 aa)
NLE1Notchless homolog 1. (485 aa)
UNC5BUNC5B isoform 2. (945 aa)
LOC466689Translationally-controlled tumor protein. (157 aa)
ENSPTRP00000091469annotation not available (400 aa)
ENSPTRP00000091883annotation not available (155 aa)
NRG1NRG1 isoform 3. (713 aa)
MAZMYC-associated zinc finger protein (Purine-binding transcription factor). (491 aa)
LOC107968189Peptidyl-prolyl cis-trans isomerase A pseudogene. (173 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (538 aa)
PRELID1PRELI domain containing 1. (219 aa)
BAXBAX isoform 7. (123 aa)
SIRT1-2Sirtuin 1. (751 aa)
EYA4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (639 aa)
RTKN2RTKN2 isoform 1. (609 aa)
LMNALMNA isoform 8; Belongs to the intermediate filament family. (664 aa)
MUC1Mucin 1, cell surface associated. (484 aa)
MCL1Myeloid cell leukemia sequence 1 (BCL2-related). (350 aa)
GNAI3Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3. (354 aa)
GCLMGlutamate-cysteine ligase, modifier subunit. (274 aa)
CTHCystathionase (Cystathionine gamma-lyase). (405 aa)
TXNDC12Thioredoxin domain containing 12 (Endoplasmic reticulum). (172 aa)
IFI6Interferon alpha-inducible protein 6; Plays a role in apoptosis, negatively regulating the intrinsinc apoptotic signaling pathway and TNFSF10-induced apoptosis (By similarity). However, it has also been shown to have a pro- apoptotic activity (By similarity). May have an antiviral activity (By similarity); Belongs to the IFI6/IFI27 family. (134 aa)
PINK1PTEN induced putative kinase 1. (581 aa)
ENO1ENO1 isoform 2. (434 aa)
ENSPTRP00000066724annotation not available (166 aa)
ENSPTRP00000066810annotation not available (262 aa)
LOC748850HDAC2 isoform 9. (445 aa)
ENSPTRP00000067872annotation not available (167 aa)
IGF1Insulin-like growth factor 1 (Somatomedin C). (196 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa)
NDUFA13NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in [...] (144 aa)
ENSPTRP00000069108annotation not available (206 aa)
ENSPTRP00000069476annotation not available (708 aa)
ENSPTRP00000069681annotation not available (400 aa)
NDUFA13-2NADH:ubiquinone oxidoreductase subunit A13. (150 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
LOC736283Glutathione peroxidase 1 pseudogene. (188 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1031 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1884 aa)
ITPRIPInositol 1,4,5-trisphosphate receptor interacting protein. (547 aa)
ENSPTRP00000070633annotation not available (178 aa)
ENSPTRP00000070902annotation not available (168 aa)
BCL2L12-2BCL2L12 isoform 12. (135 aa)
IL4-2Interleukin 4. (153 aa)
MEIS3MEIS3 isoform 5. (463 aa)
FAM167AFamily with sequence similarity 167 member A. (243 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (812 aa)
ENSPTRP00000072952annotation not available (212 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
NOL3Nucleolar protein 3. (219 aa)
ENSPTRP00000073673annotation not available (196 aa)
HTRA2HtrA serine peptidase 2. (458 aa)
IL19IL19 isoform 1. (215 aa)
TPT1Translationally-controlled tumor protein; Belongs to the TCTP family. (197 aa)
LOC454204Non-POU domain-containing octamer-binding protein. (445 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
GATA4GATA binding protein 4. (443 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
ENSPTRP00000076371annotation not available (194 aa)
ENSPTRP00000076409annotation not available (281 aa)
SRCTyrosine-protein kinase. (542 aa)
ARAndrogen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (912 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1192 aa)
OPA1OPA1 mitochondrial dynamin like GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (1015 aa)
ENSPTRP00000077985annotation not available (153 aa)
SYVN1Synovial apoptosis inhibitor 1, synoviolin. (619 aa)
MPV17LUncharacterized protein; Belongs to the peroxisomal membrane protein PXMP2/4 family. (196 aa)
ENSPTRP00000078515annotation not available (198 aa)
CFLARCASP8 and FADD-like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)
PARK7PARK7 isoform 1. (189 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (179 aa)
PPIAPeptidyl-prolyl cis-trans isomerase A, N-terminally processed; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding; Belongs to the cyclophilin-type PPIase family. PPIase A subfamily. (165 aa)
WFS1WFS1 isoform 1. (890 aa)
EPO-2Erythropoietin. (193 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
ENSPTRP00000080780annotation not available (683 aa)
RRM2BRibonucleotide reductase regulatory TP53 inducible subunit M2B. (355 aa)
ENSPTRP00000081523annotation not available (174 aa)
TCF7L2Transcription factor 7 like 2. (619 aa)
ENSPTRP00000081633annotation not available (139 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
EYA3Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (573 aa)
CTTNCTTN isoform 2. (634 aa)
ZNF385AZinc finger protein 385A. (414 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
VDAC2VDAC2 isoform 1. (260 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
SOD2Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (238 aa)
FGGFibrinogen gamma chain. (453 aa)
TAF9TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa. (255 aa)
ICAM1Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). Belongs to the immunoglobulin superfamily. ICAM family. (537 aa)
FXNFXN isoform 1. (210 aa)
CLUL1Clusterin; Belongs to the clusterin family. (524 aa)
FAIMFas apoptotic inhibitory molecule. (213 aa)
PSME3Proteasome activator subunit 3. (265 aa)
PELI3E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (469 aa)
BIRC6BIRC6 isoform 5. (4904 aa)
ENSPTRP00000086548annotation not available (433 aa)
GATA1GATA binding protein 1. (413 aa)
BDKRB2B2 bradykinin receptor isoform X1. (391 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1130 aa)
ENSPTRP00000087988annotation not available (165 aa)
THBS1Thrombospondin 1. (1173 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
XBP1XBP1 isoform 4. (381 aa)
HTTHTT isoform 1. (3131 aa)
MARCHF7MARCH7 isoform 6. (666 aa)
TMBIM6Transmembrane BAX inhibitor motif containing 6; Belongs to the BI1 family. (291 aa)
NFE2L2Nuclear factor (Erythroid-derived 2)-like 2. (605 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (733 aa)
QARS1Glutaminyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (784 aa)
PSME3-2Proteasome activator subunit 3. (265 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
SLC25A6Solute carrier family 25 member 6; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
STRADBSTE20-related kinase adaptor beta. (419 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (876 aa)
TERTTelomerase reverse transcriptase. (360 aa)
ZMYND11Zinc finger, MYND-type containing 11. (648 aa)
LOC471721Voltage-dependent anion channel 2. (297 aa)
SELENOSSELENOS isoform 5. (218 aa)
SLC25A5Solute carrier family 25 (Mitochondrial carrier adenine nucleotide translocator), member 5; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
LOC745166HSPA1A isoform 1; Belongs to the heat shock protein 70 family. (643 aa)
LOC735922Translationally-controlled tumor protein; Involved in calcium binding and microtubule stabilization. (172 aa)
LOC100614689BCL2-related ovarian killer. (207 aa)
RNF34Ring finger protein 34. (500 aa)
USP47Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1375 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (387 aa)
PLAURUrokinase plasminogen activator surface receptor; Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form (By similarity). (335 aa)
RELAV-rel reticuloendotheliosis viral oncogene homolog A (Avian). (551 aa)
ITPRIPL2Inositol 1,4,5-trisphosphate receptor interacting protein-like 2. (535 aa)
CSNK2A2Casein kinase 2, alpha prime polypeptide; Belongs to the protein kinase superfamily. (350 aa)
GPX1Glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown. (200 aa)
BAK1BCL2-antagonist/killer 1. (211 aa)
MAPK8IP2MAPK8IP2 isoform 2. (824 aa)
CREB3cAMP responsive element binding protein 3. (371 aa)
ITGAVIntegrin, alpha V (Vitronectin receptor, alpha polypeptide, antigen CD51); Belongs to the integrin alpha chain family. (1048 aa)
TMEM161ATransmembrane protein 161A. (479 aa)
URI1Chromosome 19 open reading frame 2. (537 aa)
GDNFGlial cell derived neurotrophic factor. (228 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
CD74CD74 isoform 5. (296 aa)
GSTP1Glutathione S-transferase pi 1; Belongs to the GST superfamily. (210 aa)
TAF9BTAF9B isoform 1. (251 aa)
PEA15Proliferation and apoptosis adaptor protein 15. (151 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (435 aa)
PSMD10Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 10. (226 aa)
COL2A1Collagen type II alpha 1 chain. (1487 aa)
NOC2LNOC2L isoform 4. (745 aa)
NONOnon-POU domain containing octamer binding. (471 aa)
TRIM32Tripartite motif-containing 32. (653 aa)
DNAJA1DnaJ heat shock protein family (Hsp40) member A1. (397 aa)
CAAP1Caspase activity and apoptosis inhibitor 1. (361 aa)
GRINAGlutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (Glutamate binding). (371 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
SGK3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
RB1CC1RB1-inducible coiled-coil 1. (1594 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
CLUClusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (449 aa)
CCAR2Cell cycle and apoptosis regulator 2. (923 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1203 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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