STRINGSTRING
IFI6 IFI6 GCLM GCLM MCL1 MCL1 LMNA LMNA NRP1 NRP1 YAP1 YAP1 FAIM2 FAIM2 BMP4 BMP4 LGALS3 LGALS3 MAP2K5 MAP2K5 CX3CL1 CX3CL1 MAPK7 MAPK7 RPS6KB1 RPS6KB1 PRDX2 PRDX2 IL1A IL1A IL1B IL1B TMBIM1 TMBIM1 SCG2 SCG2 PAK5 PAK5 BCL2L1 BCL2L1 HMOX1 HMOX1 SIAH2 SIAH2 PF4 PF4 SFRP2 SFRP2 FGB FGB FGA FGA SH3RF1 SH3RF1 TERT-2 TERT-2 CSF2 CSF2 IL4 IL4 CTNNA1 CTNNA1 RIPK1 RIPK1 GCLC GCLC GFRAL GFRAL BMP5 BMP5 PHIP PHIP TNFAIP3 TNFAIP3 SERPINE1 SERPINE1 ZC3HC1 ZC3HC1 NOS3 NOS3 SNAI2 SNAI2 RB1CC1 RB1CC1 SGK3 SGK3 EYA1 EYA1 COL2A1 COL2A1 PEA15 PEA15 GSTP1 GSTP1 GDNF GDNF ITGAV ITGAV GPX1 GPX1 ITPRIPL2 ITPRIPL2 RELA RELA RNF34 RNF34 LOC745166 LOC745166 ZMYND11 ZMYND11 TERT TERT STRADB STRADB PSME3-2 PSME3-2 DDX3X DDX3X HTT HTT THBS1 THBS1 ENSPTRP00000066724 ENSPTRP00000066724 IGF1 IGF1 ENSPTRP00000069681 ENSPTRP00000069681 TNF TNF LOC736283 LOC736283 ARHGEF2 ARHGEF2 BRCA1 BRCA1 ITPRIP ITPRIP ENSPTRP00000070902 ENSPTRP00000070902 IL4-2 IL4-2 HGF HGF TGFBR1 TGFBR1 NOL3 NOL3 IL19 IL19 ACVR1 ACVR1 SRC SRC AR AR AGAP2 AGAP2 CFLAR CFLAR PARK7 PARK7 IL7 IL7 BMP4-2 BMP4-2 TCF7L2 TCF7L2 ENSPTRP00000081633 ENSPTRP00000081633 GSK3B GSK3B EYA3 EYA3 CTTN CTTN AKT1 AKT1 FGF10 FGF10 FGG FGG ICAM1 ICAM1 FAIM FAIM PSME3 PSME3 PELI3 PELI3 BIRC6 BIRC6 GATA1 GATA1 ITGA6 ITGA6 RAF1 RAF1 RFFL RFFL IFI6-2 IFI6-2 BCL2 BCL2 UNC5B UNC5B ENSPTRP00000091469 ENSPTRP00000091469 NRG1 NRG1 EYA2 EYA2 EYA4 EYA4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IFI6Interferon alpha-inducible protein 6; Plays a role in apoptosis, negatively regulating the intrinsinc apoptotic signaling pathway and TNFSF10-induced apoptosis (By similarity). However, it has also been shown to have a pro- apoptotic activity (By similarity). May have an antiviral activity (By similarity); Belongs to the IFI6/IFI27 family. (134 aa)
GCLMGlutamate-cysteine ligase, modifier subunit. (274 aa)
MCL1Myeloid cell leukemia sequence 1 (BCL2-related). (350 aa)
LMNALMNA isoform 8; Belongs to the intermediate filament family. (664 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
YAP1Yes-associated protein 1. (508 aa)
FAIM2FAIM2 isoform 2; Belongs to the BI1 family. (316 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
LGALS3Galectin. (250 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
CX3CL1Chemokine (C-X3-C motif) ligand 1. (397 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (816 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
PRDX2PRDX2 isoform 1. (198 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (271 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
TMBIM1Transmembrane BAX inhibitor motif containing 1; Belongs to the BI1 family. (311 aa)
SCG2Secretogranin II. (610 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
BCL2L1BCL2L1 isoform 6. (233 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (311 aa)
SIAH2E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (324 aa)
PF4C-X-C motif chemokine. (101 aa)
SFRP2Secreted frizzled-related protein 2. (295 aa)
FGBFibrinogen beta chain. (491 aa)
FGAFibrinogen alpha chain. (866 aa)
SH3RF1SH3 domain containing ring finger 1. (888 aa)
TERT-2Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (762 aa)
CSF2Colony stimulating factor 2. (144 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4. (153 aa)
CTNNA1CTNNA1 isoform 21. (906 aa)
RIPK1Receptor (TNFRSF)-interacting serine-threonine kinase 1. (671 aa)
GCLCGlutamate-cysteine ligase, catalytic subunit. (637 aa)
GFRALGDNF family receptor alpha like. (394 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
PHIPPHIP isoform 1. (1823 aa)
TNFAIP3Tumor necrosis factor, alpha-induced protein 3. (790 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
ZC3HC1ZC3HC1 isoform 1. (502 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1203 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
RB1CC1RB1-inducible coiled-coil 1. (1594 aa)
SGK3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
COL2A1Collagen type II alpha 1 chain. (1487 aa)
PEA15Proliferation and apoptosis adaptor protein 15. (151 aa)
GSTP1Glutathione S-transferase pi 1; Belongs to the GST superfamily. (210 aa)
GDNFGlial cell derived neurotrophic factor. (228 aa)
ITGAVIntegrin, alpha V (Vitronectin receptor, alpha polypeptide, antigen CD51); Belongs to the integrin alpha chain family. (1048 aa)
GPX1Glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown. (200 aa)
ITPRIPL2Inositol 1,4,5-trisphosphate receptor interacting protein-like 2. (535 aa)
RELAV-rel reticuloendotheliosis viral oncogene homolog A (Avian). (551 aa)
RNF34Ring finger protein 34. (500 aa)
LOC745166HSPA1A isoform 1; Belongs to the heat shock protein 70 family. (643 aa)
ZMYND11Zinc finger, MYND-type containing 11. (648 aa)
TERTTelomerase reverse transcriptase. (360 aa)
STRADBSTE20-related kinase adaptor beta. (419 aa)
PSME3-2Proteasome activator subunit 3. (265 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (733 aa)
HTTHTT isoform 1. (3131 aa)
THBS1Thrombospondin 1. (1173 aa)
ENSPTRP00000066724annotation not available (166 aa)
IGF1Insulin-like growth factor 1 (Somatomedin C). (196 aa)
ENSPTRP00000069681annotation not available (400 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
LOC736283Glutathione peroxidase 1 pseudogene. (188 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1031 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1884 aa)
ITPRIPInositol 1,4,5-trisphosphate receptor interacting protein. (547 aa)
ENSPTRP00000070902annotation not available (168 aa)
IL4-2Interleukin 4. (153 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (812 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
NOL3Nucleolar protein 3. (219 aa)
IL19IL19 isoform 1. (215 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
SRCTyrosine-protein kinase. (542 aa)
ARAndrogen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (912 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1192 aa)
CFLARCASP8 and FADD-like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)
PARK7PARK7 isoform 1. (189 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (179 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
TCF7L2Transcription factor 7 like 2. (619 aa)
ENSPTRP00000081633annotation not available (139 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
EYA3Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (573 aa)
CTTNCTTN isoform 2. (634 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGGFibrinogen gamma chain. (453 aa)
ICAM1Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). Belongs to the immunoglobulin superfamily. ICAM family. (537 aa)
FAIMFas apoptotic inhibitory molecule. (213 aa)
PSME3Proteasome activator subunit 3. (265 aa)
PELI3E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (469 aa)
BIRC6BIRC6 isoform 5. (4904 aa)
GATA1GATA binding protein 1. (413 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1130 aa)
RAF1RAF1 isoform 2; Belongs to the protein kinase superfamily. (668 aa)
RFFLE3 ubiquitin-protein ligase rififylin isoform X2. (363 aa)
IFI6-2Interferon alpha inducible protein 6. (134 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
UNC5BUNC5B isoform 2. (945 aa)
ENSPTRP00000091469annotation not available (400 aa)
NRG1NRG1 isoform 3. (713 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (538 aa)
EYA4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (639 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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