STRINGSTRING
PLK1 PLK1 KLHL21 KLHL21 RMDN1 RMDN1 SPOUT1 SPOUT1 RASSF1 RASSF1 CDC25B CDC25B ANKRD53 ANKRD53 CSPP1 CSPP1 PCNT PCNT DYNC1I1 DYNC1I1 SBDS SBDS LATS1 LATS1 KATNA1 KATNA1 RGS14 RGS14 MAD2L1 MAD2L1 ALPK1 ALPK1 TACC3 TACC3 CEP19 CEP19 CEP63 CEP63 TOPBP1 TOPBP1 POC1A POC1A DYNC1LI1 DYNC1LI1 SGO1 SGO1 AURKA AURKA FAM83D FAM83D FAM110A FAM110A CUL3 CUL3 DCTN1 DCTN1 SPAST SPAST YPEL5 YPEL5 AURKC AURKC CCDC155 CCDC155 CALM3 CALM3 WDR62 WDR62 CTDP1 CTDP1 CEP95 CEP95 CDC6 CDC6 RSKR RSKR SPAG5 SPAG5 AURKB AURKB RMDN3 RMDN3 KATNBL1 KATNBL1 CEP128 CEP128 DLGAP5 DLGAP5 CKAP2 CKAP2 CDADC1 CDADC1 KATNAL1 KATNAL1 LATS2 LATS2 POC1B POC1B AAAS AAAS KAT5 KAT5 BCCIP BCCIP KIF11 KIF11 CENPF CENPF GPSM2 GPSM2 CDC20 CDC20 CEP104 CEP104 KIF20B KIF20B CKAP5 CKAP5 CETN1 CETN1 KLHL22 KLHL22 ASPM ASPM RAE1 RAE1 MAPRE1 MAPRE1 CDK5RAP2 CDK5RAP2 UBXN2B UBXN2B MAP10 MAP10 NPM1-2 NPM1-2 KIF2A KIF2A TTC28 TTC28 GIT1 GIT1 LOC735922 LOC735922 AUNIP AUNIP BEX4 BEX4 ARHGEF7 ARHGEF7 PSRC1 PSRC1 ENSPTRP00000063671 ENSPTRP00000063671 VPS4B VPS4B PKP4 PKP4 RMDN2 RMDN2 ENSPTRP00000066329 ENSPTRP00000066329 LOC743115 LOC743115 TBCCD1 TBCCD1 ENSPTRP00000067872 ENSPTRP00000067872 NPM1 NPM1 MAPKBP1 MAPKBP1 DDX11 DDX11 KATNAL2 KATNAL2 ENSPTRP00000072741 ENSPTRP00000072741 AURKB-2 AURKB-2 NDE1 NDE1 TPT1 TPT1 ENSPTRP00000074371 ENSPTRP00000074371 LOC737257 LOC737257 TNKS TNKS ENSPTRP00000075745 ENSPTRP00000075745 EFHC1 EFHC1 MTCL1 MTCL1 ENSPTRP00000078364 ENSPTRP00000078364 CEP44 CEP44 LOC737111 LOC737111 ENSPTRP00000079401 ENSPTRP00000079401 CK820_G0019795 CK820_G0019795 ENSPTRP00000081784 ENSPTRP00000081784 FBF1 FBF1 NIN NIN CALM1 CALM1 ENSPTRP00000083030 ENSPTRP00000083030 ENSPTRP00000083219 ENSPTRP00000083219 ENSPTRP00000083882 ENSPTRP00000083882 ENSPTRP00000085517 ENSPTRP00000085517 BIRC6 BIRC6 CEP85 CEP85 ENSPTRP00000087196 ENSPTRP00000087196 HSF1 HSF1 ENSPTRP00000088452 ENSPTRP00000088452 ENSPTRP00000088520 ENSPTRP00000088520 ALMS1 ALMS1 ENSPTRP00000090344 ENSPTRP00000090344 ENSPTRP00000090392 ENSPTRP00000090392 VPS4A VPS4A NEK6 NEK6 LOC466689 LOC466689 CK820_G0051860 CK820_G0051860 ENSPTRP00000092365 ENSPTRP00000092365 ENSPTRP00000092743 ENSPTRP00000092743
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLK1Serine/threonine-protein kinase PLK. (621 aa)
KLHL21Kelch like family member 21. (597 aa)
RMDN1Family with sequence similarity 82, member B. (314 aa)
SPOUT1SPOUT domain containing methyltransferase 1. (376 aa)
RASSF1Ras association (RalGDS/AF-6) domain family member 1. (340 aa)
CDC25BCell division cycle 25 homolog B. (580 aa)
ANKRD53Ankyrin repeat domain 53. (530 aa)
CSPP1Centrosome and spindle pole associated protein 1. (1221 aa)
PCNTPCNT isoform 1. (3271 aa)
DYNC1I1Dynein cytoplasmic 1 intermediate chain 1. (645 aa)
SBDSShwachman-Bodian-Diamond syndrome. (250 aa)
LATS1LATS, large tumor suppressor, homolog 1. (1130 aa)
KATNA1Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal p [...] (491 aa)
RGS14Regulator of G protein signaling 14. (566 aa)
MAD2L1MAD2 mitotic arrest deficient-like 1. (205 aa)
ALPK1ALPK1 isoform 3. (1244 aa)
TACC3Transforming acidic coiled-coil containing protein 3. (838 aa)
CEP19Chromosome 3 open reading frame 34. (167 aa)
CEP63Centrosomal protein 63kDa. (703 aa)
TOPBP1Topoisomerase (DNA) II binding protein 1. (1522 aa)
POC1APOC1 centriolar protein A. (369 aa)
DYNC1LI1Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (523 aa)
SGO1Shugoshin-like 1. (527 aa)
AURKASerine/threonine-protein kinase 6; Belongs to the protein kinase superfamily. (403 aa)
FAM83DFAM83D isoform 1. (613 aa)
FAM110AFamily with sequence similarity 110, member A. (295 aa)
CUL3CUL3 isoform 2; Belongs to the cullin family. (768 aa)
DCTN1T0125321 isoform 1. (1278 aa)
SPASTSpastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] (616 aa)
YPEL5Protein yippee-like; Belongs to the yippee family. (121 aa)
AURKCAURKC isoform 1; Belongs to the protein kinase superfamily. (309 aa)
CCDC155Coiled-coil domain containing 155. (562 aa)
CALM3Calmodulin 1 (Phosphorylase kinase, delta); Belongs to the calmodulin family. (149 aa)
WDR62WDR62 isoform 2. (1523 aa)
CTDP1RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (961 aa)
CEP95Coiled-coil domain containing 45. (821 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (560 aa)
RSKRUncharacterized serine/threonine-protein kinase SgK494 isoform X1. (410 aa)
SPAG5Sperm associated antigen 5. (1199 aa)
AURKBAURKB isoform 1; Belongs to the protein kinase superfamily. (344 aa)
RMDN3Family with sequence similarity 82, member A2. (470 aa)
KATNBL1Katanin regulatory subunit B1 like 1. (304 aa)
CEP128Centrosomal protein 128. (1094 aa)
DLGAP5Discs, large homolog-associated protein 5. (846 aa)
CKAP2Cytoskeleton associated protein 2. (682 aa)
CDADC1Cytidine and dCMP deaminase domain containing 1. (514 aa)
KATNAL1Katanin p60 ATPase-containing subunit A-like 1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neur [...] (490 aa)
LATS2Non-specific serine/threonine protein kinase. (1088 aa)
POC1BPOC1 centriolar protein homolog B isoform X2. (478 aa)
AAASAchalasia, adrenocortical insufficiency, alacrimia. (546 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa)
BCCIPBRCA2 and CDKN1A interacting protein. (322 aa)
KIF11Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1056 aa)
CENPFCentromere protein F, 350/400kDa (Mitosin). (3114 aa)
GPSM2G-protein-signaling modulator 2. (684 aa)
CDC20Cell division cycle 20 homolog. (499 aa)
CEP104Centrosomal protein 104. (925 aa)
KIF20BKIF20B isoform 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1822 aa)
CKAP5Cytoskeleton associated protein 5. (2032 aa)
CETN1CETN1 isoform 1. (172 aa)
KLHL22T0192575 isoform 1. (634 aa)
ASPMAbnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity). (3477 aa)
RAE1RAE1 RNA export 1 homolog. (368 aa)
MAPRE1MAPRE1 isoform 1. (268 aa)
CDK5RAP2CDK5 regulatory subunit-associated protein 2; Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends. Regulates centrosomal maturation by recruitment of [...] (1903 aa)
UBXN2BUBX domain protein 2B. (331 aa)
MAP10Microtubule associated protein 10. (1047 aa)
NPM1-2NPM1 isoform 5. (306 aa)
KIF2AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (744 aa)
TTC28Tetratricopeptide repeat domain 28. (2481 aa)
GIT1G protein-coupled receptor kinase interacting ArfGAP 1. (770 aa)
LOC735922Translationally-controlled tumor protein; Involved in calcium binding and microtubule stabilization. (172 aa)
AUNIPAurora kinase A and ninein interacting protein. (371 aa)
BEX4Brain expressed, X-linked 4. (120 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (862 aa)
PSRC1PSRC1 isoform 1. (363 aa)
ENSPTRP00000063671annotation not available (122 aa)
VPS4BVacuolar protein sorting 4 homolog B; Belongs to the AAA ATPase family. (446 aa)
PKP4PKP4 isoform 4. (1202 aa)
RMDN2Regulator of microtubule dynamics 2. (618 aa)
ENSPTRP00000066329annotation not available (241 aa)
LOC743115Nucleophosmin pseudogene. (255 aa)
TBCCD1TBCC domain containing 1. (557 aa)
ENSPTRP00000067872annotation not available (167 aa)
NPM1NPM1 isoform 1. (294 aa)
MAPKBP1Mitogen-activated protein kinase binding protein 1. (1514 aa)
DDX11DDX11 isoform 5. (933 aa)
KATNAL2KATNAL2 isoform 2. (538 aa)
ENSPTRP00000072741annotation not available (133 aa)
AURKB-2Aurora kinase B. (344 aa)
NDE1NudE nuclear distribution gene E homolog 1. (359 aa)
TPT1Translationally-controlled tumor protein; Belongs to the TCTP family. (197 aa)
ENSPTRP00000074371annotation not available (264 aa)
LOC737257Nucleophosmin pseudogene. (312 aa)
TNKSPoly [ADP-ribose] polymerase. (1327 aa)
ENSPTRP00000075745annotation not available (296 aa)
EFHC1EF-hand domain containing 1. (641 aa)
MTCL1MTCL1 isoform 8. (1905 aa)
ENSPTRP00000078364annotation not available (111 aa)
CEP44Centrosomal protein 44. (399 aa)
LOC737111Cell division cycle protein 20 homolog pseudogene. (482 aa)
ENSPTRP00000079401annotation not available (162 aa)
CK820_G0019795KATNAL1 isoform 4. (405 aa)
ENSPTRP00000081784annotation not available (218 aa)
FBF1T0139750 isoform 2. (1181 aa)
NINNIN isoform 1. (2133 aa)
CALM1CALM1 isoform 3; Belongs to the calmodulin family. (150 aa)
ENSPTRP00000083030annotation not available (225 aa)
ENSPTRP00000083219annotation not available (275 aa)
ENSPTRP00000083882annotation not available (275 aa)
ENSPTRP00000085517annotation not available (294 aa)
BIRC6BIRC6 isoform 5. (4904 aa)
CEP85Coiled-coil domain containing 21. (762 aa)
ENSPTRP00000087196annotation not available (261 aa)
HSF1Heat shock transcription factor 1. (529 aa)
ENSPTRP00000088452annotation not available (148 aa)
ENSPTRP00000088520annotation not available (242 aa)
ALMS1ALMS1 isoform 1. (4169 aa)
ENSPTRP00000090344annotation not available (218 aa)
ENSPTRP00000090392annotation not available (93 aa)
VPS4AVacuolar protein sorting 4 homolog A; Belongs to the AAA ATPase family. (505 aa)
NEK6NIMA related kinase 6; Belongs to the protein kinase superfamily. (373 aa)
LOC466689Translationally-controlled tumor protein. (157 aa)
CK820_G0051860DDX11 isoform 28. (265 aa)
ENSPTRP00000092365annotation not available (128 aa)
ENSPTRP00000092743annotation not available (379 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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