STRINGSTRING
DUSP11 DUSP11 RSAD2 RSAD2 NOP53 NOP53 CD3EAP CD3EAP CC2D1A CC2D1A MRI1 MRI1 TIMM44 TIMM44 MALT1 MALT1 HOXB5 HOXB5 TRAF4 TRAF4 TAF1C TAF1C PRMT7 PRMT7 CD2BP2 CD2BP2 ZNF174 ZNF174 LEO1 LEO1 SELENBP1 SELENBP1 RPP38 RPP38 STOX1 STOX1 CHCHD1 CHCHD1 LIPA LIPA ANKRD1 ANKRD1 STN1 STN1 BTBD10 BTBD10 ESRRA ESRRA PAFAH1B2 PAFAH1B2 ARHGAP32 ARHGAP32 FOXJ2 FOXJ2 RERG RERG NUAK1 NUAK1 PAK6 PAK6 EZR EZR SP140 SP140 RPAIN RPAIN ENSPTRP00000088518 ENSPTRP00000088518 YY1AP1 YY1AP1 RREB1 RREB1 CD2AP CD2AP JAZF1 JAZF1 KDM5D KDM5D POLR1C POLR1C DDX46 DDX46 POLR1E POLR1E SAMD4A SAMD4A NRIP1 NRIP1 LOC100612565 LOC100612565 KLF6 KLF6 ZNF415 ZNF415 RPP38-2 RPP38-2 ENSPTRP00000077036 ENSPTRP00000077036 SPECC1 SPECC1 UBTF UBTF SMUG1 SMUG1 LOC454204 LOC454204 ENSPTRP00000074808 ENSPTRP00000074808 ACACA ACACA RPS6KA6 RPS6KA6 SMARCA4 SMARCA4 EN2-2 EN2-2 DAB2 DAB2 EN2 EN2 DEAF1 DEAF1 FOXL2NB FOXL2NB TXNRD1 TXNRD1 POLR1B POLR1B IP6K2 IP6K2 CCDC137 CCDC137 NOP53-2 NOP53-2 LOC453669 LOC453669 HERC4 HERC4 SNAI1 SNAI1 USO1 USO1 ENSPTRP00000066188 ENSPTRP00000066188 SAP30L SAP30L ANKRD24 ANKRD24 NFIC NFIC FOXA1 FOXA1 TAX1BP3 TAX1BP3 TAF4B TAF4B POLR2F POLR2F NFIB NFIB MAP3K14 MAP3K14 RAE1 RAE1 AGER AGER PAX5 PAX5 DCLRE1A DCLRE1A FAM111A FAM111A NOLC1 NOLC1 RGS22 RGS22 NONO NONO APEX2 APEX2 AKNA AKNA EEF1D EEF1D MTDH MTDH E2F5 E2F5 THAP1 THAP1 SESN1 SESN1 CILK1 CILK1 NFKBIE NFKBIE TRERF1 TRERF1 UBD UBD TRIM27 TRIM27 CAMK4 CAMK4 OTP OTP UTP15 UTP15 FBLIM1 FBLIM1 KDM4A KDM4A RAI14 RAI14 PTPN13 PTPN13 KIT KIT TXNRD3 TXNRD3 FHIT FHIT DCAF1 DCAF1 IP6K1 IP6K1 CCR2 CCR2 URB1 URB1 TOP1 TOP1 SNRPB2 SNRPB2 SP140L SP140L WDR33 WDR33 WDR43 WDR43
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DUSP11Dual specificity phosphatase 11. (377 aa)
RSAD2RSAD2 isoform 1. (361 aa)
NOP53Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (478 aa)
CD3EAPCD3EAP isoform 1. (511 aa)
CC2D1ACoiled-coil and C2 domain containing 1A. (951 aa)
MRI1Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. (369 aa)
TIMM44Mitochondrial import inner membrane translocase subunit TIM44; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the Tim44 family. (453 aa)
MALT1Mucosa associated lymphoid tissue lymphoma translocation gene 1. (824 aa)
HOXB5HOXB5 isoform 1. (269 aa)
TRAF4TNF receptor-associated factor. (470 aa)
TAF1CTATA-box binding protein associated factor, RNA polymerase I subunit C. (869 aa)
PRMT7Protein arginine N-methyltransferase; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being r [...] (692 aa)
CD2BP2CD2 (Cytoplasmic tail) binding protein 2. (341 aa)
ZNF174T0110030 isoform 1. (407 aa)
LEO1Leo1, Paf1/RNA polymerase II complex component, homolog. (666 aa)
SELENBP1Selenium binding protein 1. (514 aa)
RPP38Ribonuclease P/MRP 38kDa subunit. (311 aa)
STOX1STOX1 isoform 1. (887 aa)
CHCHD1Coiled-coil-helix-coiled-coil-helix domain containing 1. (118 aa)
LIPALipase; Belongs to the AB hydrolase superfamily. Lipase family. (399 aa)
ANKRD1Ankyrin repeat domain 1 (Cardiac muscle). (319 aa)
STN1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (368 aa)
BTBD10BTB (POZ) domain containing 10. (475 aa)
ESRRAEstrogen-related receptor alpha. (422 aa)
PAFAH1B2Platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa). (229 aa)
ARHGAP32ARHGAP32 isoform 2. (2095 aa)
FOXJ2FOXJ2 isoform 1. (573 aa)
RERGRAS-like, estrogen-regulated, growth inhibitor. (199 aa)
NUAK1NUAK family, SNF1-like kinase, 1. (661 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
EZREZR isoform 1. (671 aa)
SP140SP140 nuclear body protein. (866 aa)
RPAINRPA interacting protein. (231 aa)
ENSPTRP00000088518annotation not available (428 aa)
YY1AP1YY1AP1 isoform 15. (843 aa)
RREB1Ras responsive element binding protein 1. (1742 aa)
CD2APCD2-associated protein. (650 aa)
JAZF1JAZF zinc finger 1. (243 aa)
KDM5DLysine-specific demethylase 5D; Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. Involved in transcriptional repression of diverse metastasis-associated genes; in this function seems to cooperate with ZMYND8. Suppresses prostate cancer cell invasion. Regulates androgen receptor (AR) transcriptional activity [...] (1566 aa)
POLR1CPolymerase (RNA) I polypeptide C, 30kDa. (350 aa)
DDX46DEAD-box helicase 46. (1031 aa)
POLR1ERNA polymerase I subunit E. (477 aa)
SAMD4ASterile alpha motif domain containing 4A. (718 aa)
NRIP1Nuclear receptor interacting protein 1. (1158 aa)
LOC100612565Steroid hormone receptor ERR1 pseudogene. (396 aa)
KLF6Kruppel-like factor 6. (302 aa)
ZNF415Zinc finger protein 415. (555 aa)
RPP38-2Ribonuclease P/MRP subunit p38. (179 aa)
ENSPTRP00000077036annotation not available (396 aa)
SPECC1Sperm antigen with calponin homology and coiled-coil domains 1. (1068 aa)
UBTFUpstream binding transcription factor, RNA polymerase I. (764 aa)
SMUG1Single-strand-selective monofunctional uracil-DNA glycosylase 1. (270 aa)
LOC454204Non-POU domain-containing octamer-binding protein. (445 aa)
ENSPTRP00000074808annotation not available (158 aa)
ACACAAcetyl-CoA carboxylase alpha. (2383 aa)
RPS6KA6Ribosomal protein S6 kinase. (745 aa)
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1679 aa)
EN2-2Homeobox protein engrailed-like. (336 aa)
DAB2Disabled homolog 2, mitogen-responsive phosphoprotein. (770 aa)
EN2Engrailed homeobox 2. (338 aa)
DEAF1Deformed epidermal autoregulatory factor 1 homolog; Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. Regulates epithelial cell proliferation and side-branching in the mammary gland. Required for neural tube closure and skeletal patterning. Controls the expressio [...] (537 aa)
FOXL2NBFOXL2NB isoform 1. (175 aa)
TXNRD1TXNRD1 isoform 3. (648 aa)
POLR1BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1135 aa)
IP6K2Kinase; Belongs to the inositol phosphokinase (IPK) family. (481 aa)
CCDC137Coiled-coil domain containing 137. (305 aa)
NOP53-2NOP53 ribosome biogenesis factor. (469 aa)
LOC453669Ribosome biogenesis protein NOP53 pseudogene. (453 aa)
HERC4Hect domain and RLD 4. (1049 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
USO1USO1 vesicle docking protein homolog. (973 aa)
ENSPTRP00000066188annotation not available (193 aa)
SAP30LSAP30L isoform 1. (183 aa)
ANKRD24ANKRD24 isoform 4. (1221 aa)
NFICNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (535 aa)
FOXA1FOXA1 isoform 1. (471 aa)
TAX1BP3Tax1-binding protein 3; May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. (124 aa)
TAF4BTAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa. (862 aa)
POLR2FRNA polymerase II subunit F. (158 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (947 aa)
RAE1RAE1 RNA export 1 homolog. (368 aa)
AGERAdvanced glycosylation end-product specific receptor. (420 aa)
PAX5PAX5 isoform 1. (391 aa)
DCLRE1ADCLRE1A isoform 1. (1040 aa)
FAM111AFamily with sequence similarity 111, member A. (611 aa)
NOLC1Nucleolar and coiled-body phosphoprotein 1. (701 aa)
RGS22Regulator of G protein signaling 22. (1264 aa)
NONOnon-POU domain containing octamer binding. (471 aa)
APEX2DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (518 aa)
AKNAAT-hook transcription factor. (1440 aa)
EEF1DEEF1D isoform 10; Belongs to the EF-1-beta/EF-1-delta family. (692 aa)
MTDHMTDH isoform 1. (582 aa)
E2F5E2F transcription factor 5. (345 aa)
THAP1THAP domain containing, apoptosis associated protein 1. (213 aa)
SESN1SESN1 isoform 1. (551 aa)
CILK1Intestinal cell (MAK-like) kinase. (632 aa)
NFKBIENFKB inhibitor epsilon. (500 aa)
TRERF1Transcriptional regulating factor 1. (1219 aa)
UBDUBD isoform 1. (165 aa)
TRIM27Tripartite motif containing 27. (513 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
OTPOrthopedia homeobox. (325 aa)
UTP15UTP15, U3 small nucleolar ribonucleoprotein, homolog. (530 aa)
FBLIM1Filamin binding LIM protein 1. (374 aa)
KDM4ALysine (K)-specific demethylase 4A. (1064 aa)
RAI14Retinoic acid induced 14. (980 aa)
PTPN13Protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase). (2490 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
TXNRD3TXNRD3 isoform 1. (642 aa)
FHITBis(5'-adenosyl)-triphosphatase. (147 aa)
DCAF1Vpr (HIV-1) binding protein. (1507 aa)
IP6K1Kinase; Belongs to the inositol phosphokinase (IPK) family. (441 aa)
CCR2C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (374 aa)
URB1URB1 ribosome biogenesis 1 homolog. (2271 aa)
TOP1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (765 aa)
SNRPB2Small nuclear ribonucleoprotein polypeptide B2. (225 aa)
SP140LSP140 nuclear body protein like. (580 aa)
WDR33WD repeat domain 33. (1336 aa)
WDR43WD repeat domain 43. (677 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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