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GTF2F2 GTF2F2 GTF2E2 GTF2E2 TAF13 TAF13 POLR2K POLR2K TAF11 TAF11 GTF2H4 GTF2H4 GTF2H2C GTF2H2C POLR2B POLR2B CK820_G0037203 CK820_G0037203 GTF2E1 GTF2E1 RPRD1B RPRD1B POLR2D POLR2D STON1 STON1 POLR2I POLR2I GTF2F1 GTF2F1 RECQL5 RECQL5 POLR2C POLR2C WDR61 WDR61 GTF2A2 GTF2A2 LEO1 LEO1 RTF1 RTF1 TAF3 TAF3 WDR47 WDR47 MNAT1 MNAT1 UPK3BL1-2 UPK3BL1-2 CCNH CCNH CDC73 CDC73 TAF1 TAF1 GTF2A1 GTF2A1 UPK3BL1 UPK3BL1 ENSPTRP00000088994 ENSPTRP00000088994 TAF8 TAF8 ENSPTRP00000088111 ENSPTRP00000088111 ENSPTRP00000088036 ENSPTRP00000088036 SUPT3H SUPT3H ERCC3 ERCC3 GTF2H5 GTF2H5 RPRD1A RPRD1A TAF9 TAF9 CK820_G0005641 CK820_G0005641 POLR2J POLR2J PAF1 PAF1 TAF7L TAF7L GTF2H1 GTF2H1 TAF12 TAF12 RPAP2 RPAP2 ERCC2 ERCC2 ENSPTRP00000078721 ENSPTRP00000078721 GTF2A2-2 GTF2A2-2 ENSPTRP00000076134 ENSPTRP00000076134 TAF5L TAF5L TCEA1 TCEA1 SH3BP5L SH3BP5L POLR2H POLR2H POLR2M POLR2M CDK7 CDK7 POLR2E POLR2E POLR2G POLR2G ENSPTRP00000070717 ENSPTRP00000070717 ENSPTRP00000069669 ENSPTRP00000069669 POLR2L POLR2L LINC02218 LINC02218 CINP CINP ENSPTRP00000064797 ENSPTRP00000064797 TAF5 TAF5 TAF6 TAF6 TAF4B TAF4B POLR2F POLR2F TAF4 TAF4 TBP TBP TAF2 TAF2 GTF2H3 GTF2H3 TAF9B TAF9B RPRD2 RPRD2 POLR2A POLR2A CTR9 CTR9 PEX2 PEX2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GTF2F2General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (249 aa)
GTF2E2Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. (291 aa)
TAF13TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa. (124 aa)
POLR2KPolymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa. (58 aa)
TAF11TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa. (211 aa)
GTF2H4General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFII [...] (462 aa)
GTF2H2CGeneral transcription factor IIH subunit. (395 aa)
POLR2BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1174 aa)
CK820_G0037203TAF4 isoform 5. (635 aa)
GTF2E1General transcription factor IIE, polypeptide 1, alpha 56kDa. (439 aa)
RPRD1BRegulation of nuclear pre-mRNA domain containing 1B. (326 aa)
POLR2DPolymerase (RNA) II (DNA directed) polypeptide D. (142 aa)
STON1Stonin-1; May be involved in the endocytic machinery. (1182 aa)
POLR2IDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (125 aa)
GTF2F1Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (517 aa)
RECQL5ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (998 aa)
POLR2CPolymerase (RNA) II (DNA directed) polypeptide C, 33kDa. (275 aa)
WDR61WD repeat domain 61. (305 aa)
GTF2A2Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (109 aa)
LEO1Leo1, Paf1/RNA polymerase II complex component, homolog. (666 aa)
RTF1Rtf1, Paf1/RNA polymerase II complex component, homolog. (710 aa)
TAF3TATA-box binding protein associated factor 3. (931 aa)
WDR47WD repeat domain 47. (927 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
UPK3BL1-2Uroplakin 3B like 1. (275 aa)
CCNHCCNH isoform 1; Belongs to the cyclin family. (325 aa)
CDC73Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog. (531 aa)
TAF1Transcription initiation factor TFIID subunit. (1927 aa)
GTF2A1General transcription factor IIA, 1, 19/37kDa. (366 aa)
UPK3BL1Uroplakin-3b-like protein 1 isoform X2. (263 aa)
ENSPTRP00000088994annotation not available (135 aa)
TAF8TATA-box binding protein associated factor 8. (338 aa)
ENSPTRP00000088111annotation not available (134 aa)
ENSPTRP00000088036annotation not available (243 aa)
SUPT3HSPT3 homolog, SAGA and STAGA complex component. (424 aa)
ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit. (782 aa)
GTF2H5General transcription factor IIH, polypeptide 5. (71 aa)
RPRD1ARegulation of nuclear pre-mRNA domain containing 1A. (312 aa)
TAF9TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa. (255 aa)
CK820_G0005641GTF2H1 isoform 5. (136 aa)
POLR2JPOLR2J2 isoform 2. (159 aa)
PAF1Paf1, RNA polymerase II associated factor, homolog. (533 aa)
TAF7LTATA-box binding protein associated factor 7 like. (457 aa)
GTF2H1General transcription factor IIH, polypeptide 1, 62kDa. (551 aa)
TAF12TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa. (213 aa)
RPAP2RNA polymerase II associated protein 2. (612 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (760 aa)
ENSPTRP00000078721annotation not available (91 aa)
GTF2A2-2General transcription factor IIA subunit 2. (72 aa)
ENSPTRP00000076134annotation not available (211 aa)
TAF5LTAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa. (589 aa)
TCEA1Transcription elongation factor A (SII), 1. (304 aa)
SH3BP5LSH3-binding domain protein 5-like. (393 aa)
POLR2HDNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (196 aa)
POLR2MGlutamate receptor, ionotropic, N-methyl D-aspartate-like 1A. (357 aa)
CDK7Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa)
POLR2EPolymerase (RNA) II (DNA directed) polypeptide E, 25kDa. (210 aa)
POLR2GPOLR2G isoform 2. (64 aa)
ENSPTRP00000070717annotation not available (287 aa)
ENSPTRP00000069669annotation not available (324 aa)
POLR2LRNA polymerase II subunit L. (67 aa)
LINC02218Long intergenic non-protein coding RNA 2218. (198 aa)
CINPCyclin dependent kinase 2 interacting protein. (227 aa)
ENSPTRP00000064797annotation not available (144 aa)
TAF5TATA-box binding protein associated factor 5. (803 aa)
TAF6TATA-box binding protein associated factor 6. (714 aa)
TAF4BTAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa. (862 aa)
POLR2FRNA polymerase II subunit F. (158 aa)
TAF4TATA-box binding protein associated factor 4. (1083 aa)
TBPTBP isoform 1. (336 aa)
TAF2TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa. (1199 aa)
GTF2H3General transcription factor IIH, polypeptide 3, 34kDa. (308 aa)
TAF9BTAF9B isoform 1. (251 aa)
RPRD2Regulation of nuclear pre-mRNA domain containing 2. (1461 aa)
POLR2ADNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1960 aa)
CTR9Ctr9, Paf1/RNA polymerase II complex component, homolog. (1173 aa)
PEX2Peroxisomal membrane protein 3, 35kDa. (305 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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