STRINGSTRING
GTF2H1 GTF2H1 MNAT1 MNAT1 CCNH CCNH BRD4 BRD4 CCNT1 CCNT1 IAH1 IAH1 ERCC3 ERCC3 GTF2H5 GTF2H5 CK820_G0005641 CK820_G0005641 LARP7 LARP7 ERCC2 ERCC2 SH3BP5L SH3BP5L CDK7 CDK7 ENSPTRP00000069669 ENSPTRP00000069669 HEXIM1 HEXIM1 CDK12 CDK12 CCNK CCNK GTF2H3 GTF2H3 CCNT2 CCNT2 CDK9 CDK9 CDK13 CDK13 GTF2H4 GTF2H4 ZNF346 ZNF346 GTF2H2C GTF2H2C
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GTF2H1General transcription factor IIH, polypeptide 1, 62kDa. (551 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
CCNHCCNH isoform 1; Belongs to the cyclin family. (325 aa)
BRD4Bromodomain containing 4. (1362 aa)
CCNT1Cyclin-T1; Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (C- terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). In case of SIV infection, binds to the nuclear transcriptional activator Tat, increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing [...] (725 aa)
IAH1Isoamyl acetate hydrolyzing esterase 1 (putative). (248 aa)
ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit. (782 aa)
GTF2H5General transcription factor IIH, polypeptide 5. (71 aa)
CK820_G0005641GTF2H1 isoform 5. (136 aa)
LARP7La ribonucleoprotein domain family member 7. (589 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (760 aa)
SH3BP5LSH3-binding domain protein 5-like. (393 aa)
CDK7Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa)
ENSPTRP00000069669annotation not available (324 aa)
HEXIM1Hexamethylene bis-acetamide inducible 1. (359 aa)
CDK12Cyclin-dependent kinase 12. (1490 aa)
CCNKCCNK isoform 2; Belongs to the cyclin family. (572 aa)
GTF2H3General transcription factor IIH, polypeptide 3, 34kDa. (308 aa)
CCNT2CCNT2 isoform 4; Belongs to the cyclin family. (730 aa)
CDK9Cyclin-dependent kinase 9; Belongs to the protein kinase superfamily. (372 aa)
CDK13Cyclin dependent kinase 13. (1512 aa)
GTF2H4General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFII [...] (462 aa)
ZNF346Zinc finger protein 346. (319 aa)
GTF2H2CGeneral transcription factor IIH subunit. (395 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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