8 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSPTRP00000079019	annotation not available (165 aa)
	TF	Serotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation (By similarity). (698 aa)
	HJV	HFE2 isoform 1. (426 aa)
	HFE	Hereditary hemochromatosis protein homolog; Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin. (348 aa)
	ENSPTRP00000078404	annotation not available (801 aa)
	TFRC	Transferrin receptor (P90, CD71). (760 aa)
	TFR2	Transferrin receptor 2. (801 aa)
	BMPR1B	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMPR1B	HJV	ENSPTRP00000027988	ENSPTRP00000085910	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	HFE2 isoform 1.	0.920
ENSPTRP00000078404	ENSPTRP00000079019	ENSPTRP00000078404	ENSPTRP00000079019	annotation not available	annotation not available	0.574
ENSPTRP00000078404	HFE	ENSPTRP00000078404	ENSPTRP00000079201	annotation not available	Hereditary hemochromatosis protein homolog; Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.	0.943
ENSPTRP00000078404	HJV	ENSPTRP00000078404	ENSPTRP00000085910	annotation not available	HFE2 isoform 1.	0.720
ENSPTRP00000078404	TF	ENSPTRP00000078404	ENSPTRP00000026561	annotation not available	Serotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation (By similarity).	0.674
ENSPTRP00000078404	TFRC	ENSPTRP00000078404	ENSPTRP00000046807	annotation not available	Transferrin receptor (P90, CD71).	0.516
ENSPTRP00000079019	ENSPTRP00000078404	ENSPTRP00000079019	ENSPTRP00000078404	annotation not available	annotation not available	0.574
ENSPTRP00000079019	HFE	ENSPTRP00000079019	ENSPTRP00000079201	annotation not available	Hereditary hemochromatosis protein homolog; Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.	0.779
ENSPTRP00000079019	TFR2	ENSPTRP00000079019	ENSPTRP00000033379	annotation not available	Transferrin receptor 2.	0.574
ENSPTRP00000079019	TFRC	ENSPTRP00000079019	ENSPTRP00000046807	annotation not available	Transferrin receptor (P90, CD71).	0.776
HFE	ENSPTRP00000078404	ENSPTRP00000079201	ENSPTRP00000078404	Hereditary hemochromatosis protein homolog; Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.	annotation not available	0.943
HFE	ENSPTRP00000079019	ENSPTRP00000079201	ENSPTRP00000079019	Hereditary hemochromatosis protein homolog; Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.	annotation not available	0.779
HFE	HJV	ENSPTRP00000079201	ENSPTRP00000085910	Hereditary hemochromatosis protein homolog; Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.	HFE2 isoform 1.	0.922
HFE	TF	ENSPTRP00000079201	ENSPTRP00000026561	Hereditary hemochromatosis protein homolog; Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.	Serotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation (By similarity).	0.480
HFE	TFR2	ENSPTRP00000079201	ENSPTRP00000033379	Hereditary hemochromatosis protein homolog; Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.	Transferrin receptor 2.	0.964
HFE	TFRC	ENSPTRP00000079201	ENSPTRP00000046807	Hereditary hemochromatosis protein homolog; Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.	Transferrin receptor (P90, CD71).	0.999
HJV	BMPR1B	ENSPTRP00000085910	ENSPTRP00000027988	HFE2 isoform 1.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.920
HJV	ENSPTRP00000078404	ENSPTRP00000085910	ENSPTRP00000078404	HFE2 isoform 1.	annotation not available	0.720
HJV	HFE	ENSPTRP00000085910	ENSPTRP00000079201	HFE2 isoform 1.	Hereditary hemochromatosis protein homolog; Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.	0.922
HJV	TFR2	ENSPTRP00000085910	ENSPTRP00000033379	HFE2 isoform 1.	Transferrin receptor 2.	0.812