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FER1L6 FER1L6 CAPN6 CAPN6 WWC2 WWC2 C2CD5 C2CD5 ITSN1-2 ITSN1-2 SYT17 SYT17 HECW1 HECW1 SYTL3 SYTL3 PLA2G4F PLA2G4F UNC13B UNC13B UNC13A UNC13A SYT14 SYT14 RAB11FIP5 RAB11FIP5 SYT6 SYT6 CPNE2 CPNE2 PLCB3 PLCB3 PLCH2-2 PLCH2-2 C2CD4C C2CD4C PLCD3 PLCD3 CADPS2 CADPS2 SYT16 SYT16 TOLLIP TOLLIP ITSN1 ITSN1 INPP4A INPP4A LOC751039 LOC751039 PIK3C2B PIK3C2B MCTP2 MCTP2 PLCD1 PLCD1 CC2D1B CC2D1B PRKCQ PRKCQ PLCH1 PLCH1 PKN1 PKN1 RIMS1 RIMS1 CK820_G0051619 CK820_G0051619 PLCG2 PLCG2 CPNE7 CPNE7 MCTP1 MCTP1 SYT8 SYT8 RPGRIP1 RPGRIP1 RAB11FIP2 RAB11FIP2 FER1L5 FER1L5 PIK3C2G PIK3C2G INPP4B INPP4B SYT7 SYT7 WWP2 WWP2 SYT15 SYT15 PLCZ1 PLCZ1 PLCD4 PLCD4 SYTL1 SYTL1 OTOF OTOF FER1L4 FER1L4 PLCL2 PLCL2 C2CD4B C2CD4B PCLO PCLO C2CD2L C2CD2L RPH3A RPH3A C2CD3 C2CD3 CAPN5 CAPN5 CC2D2A CC2D2A SYNGAP1 SYNGAP1 CCDC33 CCDC33 ESYT2 ESYT2 SYT11 SYT11 SYTL5 SYTL5 LOC749464 LOC749464 C2CD4D C2CD4D LOC104007584 LOC104007584 RASAL3 RASAL3 DAB2IP DAB2IP DYSF DYSF DOC2B DOC2B PLCE1 PLCE1 C2CD4A C2CD4A ESYT3 ESYT3 SYT10 SYT10 C2CD6 C2CD6 SMURF1 SMURF1 SYT1 SYT1 CPNE4 CPNE4 SYTL2 SYTL2 ITCH ITCH TC2N TC2N RGS3 RGS3 BCR BCR WWC3 WWC3 SYTL4 SYTL4 RIMS2 RIMS2 CPNE3 CPNE3 WWP1 WWP1 RAB11FIP1 RAB11FIP1 CPNE5 CPNE5 WWC1 WWC1 CEP120 CEP120 RASA1 RASA1 RASA2 RASA2 CADPS CADPS PRKCD PRKCD CPNE9 CPNE9 C2CD2 C2CD2 RIMS4 RIMS4 PLCG1 PLCG1 PLCB4 PLCB4 PLCB1 PLCB1 PLCL1 PLCL1 HECW2 HECW2 PRKCE PRKCE ITSN2 ITSN2 SYT5 SYT5 PRKCG PRKCG SYT3 SYT3 SYDE1 SYDE1 CC2D1A CC2D1A SYT4 SYT4 UNC13D UNC13D PRKCA PRKCA ABR ABR RPGRIP1L RPGRIP1L DOC2A DOC2A PRKCB PRKCB BAIAP3 BAIAP3 UNC13C UNC13C PLA2G4D PLA2G4D PLA2G4E PLA2G4E PLCB2 PLCB2 PRKCH PRKCH CPNE6 CPNE6 RASA3 RASA3 RASAL1 RASAL1 ESYT1 ESYT1 CPNE8 CPNE8 UVRAG UVRAG SYT12 SYT12 SYT13 SYT13 PIK3C2A PIK3C2A SYT9 SYT9 MYOF MYOF PRF1 PRF1 SYT2 SYT2 PLA2G4A PLA2G4A RASAL2 RASAL2 PKN2 PKN2 SYDE2 SYDE2 RIMS3 RIMS3 PLCH2 PLCH2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FER1L6FER1L6 isoform 1. (1867 aa)
CAPN6CAPN6 isoform 1; Belongs to the peptidase C2 family. (651 aa)
WWC2WW and C2 domain containing 2. (1196 aa)
C2CD5C2CD5 isoform 5. (1084 aa)
ITSN1-2ITSN1 isoform 7. (1716 aa)
SYT17Synaptotagmin 17. (481 aa)
HECW1HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1. (1608 aa)
SYTL3Synaptotagmin-like 3. (610 aa)
PLA2G4FPhospholipase A2. (849 aa)
UNC13BUNC13B isoform 2. (4343 aa)
UNC13AUNC13A isoform 2. (1693 aa)
SYT14SYT14 isoform 1. (864 aa)
RAB11FIP5RAB11FIP5 isoform 1. (1320 aa)
SYT6Synaptotagmin 6. (548 aa)
CPNE2CPNE2 isoform 1. (548 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
PLCH2-2Phosphoinositide phospholipase C. (1129 aa)
C2CD4CC2 calcium dependent domain containing 4C. (421 aa)
PLCD3Phosphoinositide phospholipase C. (789 aa)
CADPS2CADPS2 isoform 3. (1302 aa)
SYT16Synaptotagmin 16. (645 aa)
TOLLIPToll interacting protein. (275 aa)
ITSN1ITSN1 isoform 4. (1721 aa)
INPP4AInositol polyphosphate-4-phosphatase type I A. (977 aa)
LOC751039Uncharacterized protein. (613 aa)
PIK3C2BPhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. (1634 aa)
MCTP2Multiple C2 and transmembrane domain containing 2. (934 aa)
PLCD1Phosphoinositide phospholipase C. (779 aa)
CC2D1BCoiled-coil and C2 domain containing 1B. (858 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (845 aa)
PLCH1Phosphoinositide phospholipase C. (1693 aa)
PKN1PKN1 isoform 2. (948 aa)
RIMS1Regulating synaptic membrane exocytosis 1. (1692 aa)
CK820_G0051619CPNE7 isoform 9. (170 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
CPNE7CPNE7 isoform 2. (526 aa)
MCTP1MCTP1 isoform 1. (997 aa)
SYT8Synaptotagmin 8. (401 aa)
RPGRIP1RPGR interacting protein 1. (1287 aa)
RAB11FIP2RAB11 family interacting protein 2. (532 aa)
FER1L5FER1L5 isoform 5. (1974 aa)
PIK3C2GPhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma; Belongs to the PI3/PI4-kinase family. (1486 aa)
INPP4BInositol polyphosphate-4-phosphatase type II B. (938 aa)
SYT7Synaptotagmin 7. (686 aa)
WWP2E3 ubiquitin-protein ligase. (870 aa)
SYT15SYT15 isoform 1. (479 aa)
PLCZ1Phosphoinositide phospholipase C. (639 aa)
PLCD4Phosphoinositide phospholipase C. (794 aa)
SYTL1Synaptotagmin like 1. (562 aa)
OTOFOTOF isoform 1. (1997 aa)
FER1L4FER1L4 isoform 6. (2054 aa)
PLCL2Phosphoinositide phospholipase C. (1127 aa)
C2CD4BC2 calcium dependent domain containing 4B. (364 aa)
PCLOPiccolo presynaptic cytomatrix protein. (5203 aa)
C2CD2LC2CD2L isoform 1. (711 aa)
RPH3ARPH3A isoform 2. (694 aa)
C2CD3C2CD3 isoform 3. (2298 aa)
CAPN5CAPN5 isoform 5; Belongs to the peptidase C2 family. (680 aa)
CC2D2ACC2D2A isoform 1. (1627 aa)
SYNGAP1Synaptic Ras GTPase activating protein 1. (1345 aa)
CCDC33Coiled-coil domain containing 33. (755 aa)
ESYT2ESYT2 isoform 1. (897 aa)
SYT11Synaptotagmin 11. (431 aa)
SYTL5Synaptotagmin like 5. (752 aa)
LOC749464Phospholipase A2. (781 aa)
C2CD4DC2 calcium dependent domain containing 4D. (353 aa)
LOC104007584UNC13B isoform 3. (1549 aa)
RASAL3RASAL3 isoform 1. (1011 aa)
DAB2IPDAB2 interacting protein. (1189 aa)
DYSFDYSF isoform 8. (2119 aa)
DOC2BDouble C2-like domain-containing protein. (412 aa)
PLCE1Phosphoinositide phospholipase C. (2301 aa)
C2CD4AC2CD4A isoform 1. (346 aa)
ESYT3Extended synaptotagmin-like protein 3. (886 aa)
SYT10Synaptotagmin 10. (523 aa)
C2CD6C2CD6 isoform 3. (1819 aa)
SMURF1E3 ubiquitin-protein ligase. (757 aa)
SYT1Synaptotagmin 1. (422 aa)
CPNE4CPNE4 isoform 3. (575 aa)
SYTL2Synaptotagmin like 2. (2223 aa)
ITCHE3 ubiquitin-protein ligase. (862 aa)
TC2NTandem C2 domains, nuclear. (490 aa)
RGS3RGS3 isoform 4. (1198 aa)
BCRBCR activator of RhoGEF and GTPase. (1271 aa)
WWC3WWC family member 3. (1201 aa)
SYTL4Synaptotagmin-like 4. (672 aa)
RIMS2Regulating synaptic membrane exocytosis 2. (1367 aa)
CPNE3CPNE3 isoform 1. (537 aa)
WWP1E3 ubiquitin-protein ligase. (922 aa)
RAB11FIP1RAB11 family interacting protein 1. (1283 aa)
CPNE5CPNE5 isoform 2. (593 aa)
WWC1WWC1 isoform 7. (1119 aa)
CEP120Centrosomal protein 120kDa. (986 aa)
RASA1RAS p21 protein activator (GTPase activating protein) 1. (1047 aa)
RASA2RAS p21 protein activator 2. (849 aa)
CADPSCalcium dependent secretion activator. (1374 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
CPNE9Copine family member 9. (553 aa)
C2CD2C2 calcium-dependent domain containing 2. (696 aa)
RIMS4Regulating synaptic membrane exocytosis 4. (270 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PLCL1Phosphoinositide phospholipase C. (1095 aa)
HECW2HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2. (1572 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
ITSN2ITSN2 isoform 1. (1684 aa)
SYT5Synaptotagmin 5. (386 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
SYT3Synaptotagmin 3. (590 aa)
SYDE1Synapse defective 1, Rho GTPase, homolog 1. (735 aa)
CC2D1ACoiled-coil and C2 domain containing 1A. (951 aa)
SYT4Synaptotagmin 4. (425 aa)
UNC13DUNC13D isoform 1. (1090 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
ABRActive BCR-related protein. (840 aa)
RPGRIP1LRPGRIP1L isoform 4. (1269 aa)
DOC2ADouble C2-like domain-containing protein. (400 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
BAIAP3BAIAP3 isoform 4. (1172 aa)
UNC13CUNC13C isoform 1. (2217 aa)
PLA2G4DPhospholipase A2. (818 aa)
PLA2G4EPhospholipase A2. (868 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
PRKCHProtein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] (683 aa)
CPNE6CPNE6 isoform 2. (565 aa)
RASA3RAS p21 protein activator 3. (740 aa)
RASAL1RAS protein activator like 1. (806 aa)
ESYT1Extended synaptotagmin-like protein 1. (1114 aa)
CPNE8CPNE8 isoform 2. (564 aa)
UVRAGUV radiation resistance associated protein. (699 aa)
SYT12Synaptotagmin 12. (420 aa)
SYT13SYT13 isoform 1. (426 aa)
PIK3C2APhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1686 aa)
SYT9Synaptotagmin IX. (491 aa)
MYOFMYOF isoform 3. (2061 aa)
PRF1PRF1 isoform 1. (555 aa)
SYT2Synaptotagmin 2. (419 aa)
PLA2G4APhospholipase A2. (749 aa)
RASAL2RAS protein activator like 2. (1280 aa)
PKN2Protein kinase N2. (984 aa)
SYDE2Synapse defective Rho GTPase homolog 2. (1194 aa)
RIMS3Regulating synaptic membrane exocytosis 3. (308 aa)
PLCH2Phosphoinositide phospholipase C. (1416 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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