10 items (Pan troglodytes) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	CASP12	CASP12 isoform 1; Belongs to the peptidase C14A family. (341 aa)
	CASP3	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (277 aa)
	CASP6	Caspase 6, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (293 aa)
	CASP14	CASP14 isoform 1; Belongs to the peptidase C14A family. (242 aa)
	CASP7	CASP7 isoform 1; Belongs to the peptidase C14A family. (388 aa)
	CASP9	CASP9 isoform 4; Belongs to the peptidase C14A family. (421 aa)
	CASP1	CASP1 isoform 4; Belongs to the peptidase C14A family. (404 aa)
	CASP5	CASP5 isoform 3; Belongs to the peptidase C14A family. (448 aa)
	CASP2	Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (452 aa)
	CASP4	Caspase 4, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (377 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP1	CASP12	ENSPTRP00000078835	ENSPTRP00000047678	CASP1 isoform 4; Belongs to the peptidase C14A family.	CASP12 isoform 1; Belongs to the peptidase C14A family.	0.903
CASP1	CASP4	ENSPTRP00000078835	ENSPTRP00000041705	CASP1 isoform 4; Belongs to the peptidase C14A family.	Caspase 4, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.899
CASP1	CASP5	ENSPTRP00000078835	ENSPTRP00000007279	CASP1 isoform 4; Belongs to the peptidase C14A family.	CASP5 isoform 3; Belongs to the peptidase C14A family.	0.920
CASP1	CASP6	ENSPTRP00000078835	ENSPTRP00000080795	CASP1 isoform 4; Belongs to the peptidase C14A family.	Caspase 6, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.670
CASP12	CASP1	ENSPTRP00000047678	ENSPTRP00000078835	CASP12 isoform 1; Belongs to the peptidase C14A family.	CASP1 isoform 4; Belongs to the peptidase C14A family.	0.903
CASP12	CASP3	ENSPTRP00000047678	ENSPTRP00000054330	CASP12 isoform 1; Belongs to the peptidase C14A family.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	0.919
CASP12	CASP4	ENSPTRP00000047678	ENSPTRP00000041705	CASP12 isoform 1; Belongs to the peptidase C14A family.	Caspase 4, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.678
CASP12	CASP5	ENSPTRP00000047678	ENSPTRP00000007279	CASP12 isoform 1; Belongs to the peptidase C14A family.	CASP5 isoform 3; Belongs to the peptidase C14A family.	0.679
CASP12	CASP7	ENSPTRP00000047678	ENSPTRP00000074501	CASP12 isoform 1; Belongs to the peptidase C14A family.	CASP7 isoform 1; Belongs to the peptidase C14A family.	0.919
CASP14	CASP9	ENSPTRP00000060440	ENSPTRP00000089496	CASP14 isoform 1; Belongs to the peptidase C14A family.	CASP9 isoform 4; Belongs to the peptidase C14A family.	0.590
CASP2	CASP3	ENSPTRP00000033919	ENSPTRP00000054330	Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	0.648
CASP2	CASP7	ENSPTRP00000033919	ENSPTRP00000074501	Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	CASP7 isoform 1; Belongs to the peptidase C14A family.	0.446
CASP2	CASP9	ENSPTRP00000033919	ENSPTRP00000089496	Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	CASP9 isoform 4; Belongs to the peptidase C14A family.	0.605
CASP3	CASP12	ENSPTRP00000054330	ENSPTRP00000047678	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	CASP12 isoform 1; Belongs to the peptidase C14A family.	0.919
CASP3	CASP2	ENSPTRP00000054330	ENSPTRP00000033919	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.648
CASP3	CASP6	ENSPTRP00000054330	ENSPTRP00000080795	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	Caspase 6, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.853
CASP3	CASP7	ENSPTRP00000054330	ENSPTRP00000074501	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	CASP7 isoform 1; Belongs to the peptidase C14A family.	0.964
CASP3	CASP9	ENSPTRP00000054330	ENSPTRP00000089496	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	CASP9 isoform 4; Belongs to the peptidase C14A family.	0.996
CASP4	CASP1	ENSPTRP00000041705	ENSPTRP00000078835	Caspase 4, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	CASP1 isoform 4; Belongs to the peptidase C14A family.	0.899
CASP4	CASP12	ENSPTRP00000041705	ENSPTRP00000047678	Caspase 4, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	CASP12 isoform 1; Belongs to the peptidase C14A family.	0.678