STRINGSTRING
EPHA2 EPHA2 EPHA8 EPHA8 FGR FGR LCK LCK TIE1 TIE1 TESK2 TESK2 JAK1 JAK1 DDR2 DDR2 RET RET FGFR2 FGFR2 FLT3 FLT3 FLT1 FLT1 LTK LTK TYRO3 TYRO3 CSK CSK PEAK1 PEAK1 FES FES IGF1R IGF1R TNK1 TNK1 AATK AATK LMTK3 LMTK3 ALK ALK ZAP70 ZAP70 TTN TTN HCK HCK SRMS SRMS MST1R MST1R EPHA3 EPHA3 EPHA6 EPHA6 RYK RYK PDGFRA PDGFRA KIT KIT KDR KDR EPHA5 EPHA5 PLK4 PLK4 FER FER ITK ITK FGFR4 FGFR4 EPHA7 EPHA7 FRK FRK EPHB4 EPHB4 EPHA1 EPHA1 PTK2B PTK2B TESK1 TESK1 ROR2 ROR2 JAK3 JAK3 MATK MATK FLT4 FLT4 LYN LYN TYK2 TYK2 EPHB2 EPHB2 EPHB1 EPHB1 PTK6 PTK6 TP53RK TP53RK INSR INSR ERBB4 ERBB4 FGFR1 FGFR1 LMTK2 LMTK2 OBSCN OBSCN ABL2 ABL2 BMX BMX PRAG1 PRAG1 NEK10 NEK10 TNK2 TNK2 YES1 YES1 FGFR3 FGFR3 PTK7 PTK7 MUSK MUSK AXL AXL ROR1 ROR1 EPHA4 EPHA4 TXK TXK NTRK3 NTRK3 PTK2 PTK2 NTRK1 NTRK1 MET MET JAK2 JAK2 STYK1 STYK1 CSF1R CSF1R PDGFRB PDGFRB TXK-2 TXK-2 FYN FYN NTRK2 NTRK2 SRC SRC MERTK MERTK SYK SYK EPHB3 EPHB3 ABL1 ABL1 TEC TEC INSRR INSRR TEK TEK ERBB2 ERBB2 EGFR EGFR DDR1 DDR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EPHA2EPH receptor A2. (976 aa)
EPHA8EPHA8 isoform 1. (997 aa)
FGRTyrosine-protein kinase. (529 aa)
LCKTyrosine-protein kinase. (539 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1138 aa)
TESK2TESK2 isoform 1. (542 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (855 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1116 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
LTKTyrosine-protein kinase receptor. (864 aa)
TYRO3TYRO3 protein tyrosine kinase. (890 aa)
CSKTyrosine-protein kinase. (450 aa)
PEAK1NKF3 kinase family member. (1746 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (827 aa)
IGF1RTyrosine-protein kinase receptor. (1364 aa)
TNK1TNK1 isoform 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (661 aa)
AATKAATK isoform 3. (1380 aa)
LMTK3LMTK3 isoform 1. (1493 aa)
ALKTyrosine-protein kinase receptor. (1620 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
TTNTTN isoform 3. (32000 aa)
HCKTyrosine-protein kinase. (526 aa)
SRMSTyrosine-protein kinase. (447 aa)
MST1RMacrophage stimulating 1 receptor. (1400 aa)
EPHA3EPH receptor A3. (983 aa)
EPHA6EPH receptor A6. (1130 aa)
RYKReceptor like tyrosine kinase. (610 aa)
PDGFRAT0011027 isoform 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1102 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
EPHA5EPH receptor A5. (1038 aa)
PLK4Polo-like kinase 4. (970 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
ITKTyrosine-protein kinase. (620 aa)
FGFR4Fibroblast growth factor receptor. (802 aa)
EPHA7EPHA7 isoform 2. (998 aa)
FRKTyrosine-protein kinase. (505 aa)
EPHB4EPH receptor B4. (987 aa)
EPHA1EPH receptor A1. (976 aa)
PTK2BPTK2B protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
TESK1Testis associated actin remodelling kinase 1. (626 aa)
ROR2Receptor tyrosine kinase-like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (943 aa)
JAK3Tyrosine-protein kinase. (1124 aa)
MATKTyrosine-protein kinase. (508 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1363 aa)
LYNTyrosine-protein kinase. (512 aa)
TYK2Tyrosine-protein kinase. (1184 aa)
EPHB2EPH receptor B2. (1055 aa)
EPHB1EPH receptor B1. (984 aa)
PTK6Tyrosine-protein kinase. (451 aa)
TP53RKTP53 regulating kinase. (253 aa)
INSRTyrosine-protein kinase receptor. (1408 aa)
ERBB4Receptor protein-tyrosine kinase. (1386 aa)
FGFR1Fibroblast growth factor receptor. (854 aa)
LMTK2Lemur tyrosine kinase 2. (1503 aa)
OBSCNObscurin, cytoskeletal calmodulin and titin-interacting RhoGEF. (8919 aa)
ABL2Tyrosine-protein kinase. (1182 aa)
BMXTyrosine-protein kinase. (679 aa)
PRAG1PRAG1 isoform 1. (1408 aa)
NEK10NIMA related kinase 10. (1173 aa)
TNK2TNK2 isoform 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1086 aa)
YES1Tyrosine-protein kinase. (558 aa)
FGFR3Fibroblast growth factor receptor. (808 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1078 aa)
MUSKMuscle associated receptor tyrosine kinase. (879 aa)
AXLAXL receptor tyrosine kinase. (894 aa)
ROR1Receptor tyrosine kinase-like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (945 aa)
EPHA4EPH receptor A4. (986 aa)
TXKTyrosine-protein kinase. (527 aa)
NTRK3NT-3 growth factor receptor; Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. (864 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1113 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1413 aa)
JAK2Tyrosine-protein kinase. (1143 aa)
STYK1Serine/threonine/tyrosine kinase 1. (422 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
TXK-2TXK tyrosine kinase. (530 aa)
FYNTyrosine-protein kinase. (537 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
SRCTyrosine-protein kinase. (542 aa)
MERTKMERTK isoform 1. (963 aa)
SYKTyrosine-protein kinase. (635 aa)
EPHB3EPHB3 isoform 1. (1031 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
TECTyrosine-protein kinase. (631 aa)
INSRRTyrosine-protein kinase receptor. (1297 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
DDR1Epithelial discoidin domain-containing receptor 1; Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Promotes sm [...] (920 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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