STRINGSTRING
PAX7 PAX7 POU4F1 POU4F1 BARHL2 BARHL2 ALX3 ALX3 LMX1A LMX1A PRRX1 PRRX1 LHX4 LHX4 HLX HLX MKX MKX DRGX DRGX HHEX HHEX PITX3 PITX3 EMX2 EMX2 NKX6-2 NKX6-2 VENTX VENTX POU2F3 POU2F3 BSX BSX BARX2 BARX2 NANOG NANOG DBX2 DBX2 HOXC13 HOXC13 HOXC12 HOXC12 HOXC11 HOXC11 HOXC9 HOXC9 HOXC8 HOXC8 HOXC6 HOXC6 ALX1 ALX1 LHX5 LHX5 GSX1 GSX1 PDX1 PDX1 NKX2-8 NKX2-8 OTX2 OTX2 VSX2 VSX2 GSC GSC ISL2 ISL2 IRX3 IRX3 IRX6 IRX6 ZFHX3 ZFHX3 MEOX1 MEOX1 HOXB1 HOXB1 HOXB2 HOXB2 HOXB4 HOXB4 HOXB5 HOXB5 HOXB6 HOXB6 HOXB7 HOXB7 HOXB13 HOXB13 DLX4 DLX4 DLX3 DLX3 RAX RAX RAX2 RAX2 CRX CRX SIX2 SIX2 OTX1 OTX1 VAX2 VAX2 TLX2 TLX2 DLX2 DLX2 EVX2 EVX2 HOXD13 HOXD13 HOXD10 HOXD10 GBX2 GBX2 NKX2-4 NKX2-4 NKX2-2 NKX2-2 ISX ISX HESX1 HESX1 POU1F1 POU1F1 ARGFX ARGFX PHOX2B PHOX2B GSX2 GSX2 NKX6-1 NKX6-1 PITX2 PITX2 POU4F2 POU4F2 IRX2 IRX2 IRX1 IRX1 ISL1 ISL1 OTP OTP PITX1 PITX1 CDX1 CDX1 TLX3 TLX3 NKX2-5 NKX2-5 MSX2 MSX2 PROP1 PROP1 POU5F1 POU5F1 PBX2 PBX2 MEOX2 MEOX2 HOXA1 HOXA1 HOXA2 HOXA2 HOXA5 HOXA5 HOXA7 HOXA7 HOXA11 HOXA11 EVX1 EVX1 DLX5 DLX5 PAX4 PAX4 GBX1 GBX1 NKX2-6 NKX2-6 LHX2 LHX2 LMX1B LMX1B PRRX2 PRRX2 BARHL1 BARHL1 CDX4 CDX4 DLX1 DLX1 ZFHX4 ZFHX4 HOXA4 HOXA4 SIX4 SIX4 HOXB9 HOXB9 DMBX1 DMBX1 BARX1 BARX1 MNX1 MNX1 PHOX2A PHOX2A HOXA13-2 HOXA13-2 CK820_G0042272 CK820_G0042272 SIX5 SIX5 EN1 EN1 LBX1 LBX1 POU3F1 POU3F1 ZFHX2 ZFHX2 NKX6-3 NKX6-3 LHX1 LHX1 HOXD8 HOXD8 MSX1 MSX1 HOXD11 HOXD11 EMX1 EMX1 DLX6 DLX6 HOXA6 HOXA6 HOXD12 HOXD12 POU3F4 POU3F4 NKX1-1 NKX1-1 ANHX ANHX DUXB DUXB PBX1 PBX1 NKX1-2 NKX1-2 HOXB3 HOXB3 LHX3 LHX3 UNCX UNCX GSC2 GSC2 PAX6 PAX6 RHOXF1 RHOXF1 HOXA10 HOXA10 HMX1 HMX1 IRX5 IRX5 HOXA3 HOXA3 DBX1 DBX1 NKX3-2 NKX3-2 SHOX SHOX SIX1 SIX1 CDX2 CDX2 ARX ARX MIXL1 MIXL1 HOXC5 HOXC5 TLX1 TLX1 LHX8 LHX8 NKX2-1 NKX2-1 EN2-2 EN2-2 IRX4 IRX4 HOXC4 HOXC4 NKX2-3 NKX2-3 POU3F3 POU3F3 POU2F1 POU2F1 HMX3 HMX3 LHX9 LHX9 HOXD9 HOXD9 POU2F2 POU2F2 NKX3-1 NKX3-1 ALX4 ALX4 HMX2 HMX2 VSX1 VSX1 LEUTX LEUTX LHX6 LHX6 HOXD3 HOXD3 VAX1 VAX1 HOXD4 HOXD4 HOXB8 HOXB8 CUX2 CUX2 HOXD1 HOXD1 POU5F1B POU5F1B CUX1 CUX1 PAX3 PAX3 SHOX2 SHOX2 ESX1 ESX1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PAX7PAX7 isoform 2. (505 aa)
POU4F1POU domain protein. (350 aa)
BARHL2BarH like homeobox 2. (387 aa)
ALX3ALX homeobox 3. (343 aa)
LMX1ALIM homeobox transcription factor 1 alpha. (382 aa)
PRRX1Paired related homeobox 1. (245 aa)
LHX4LHX4 isoform 1. (390 aa)
HLXH2.0-like homeobox. (493 aa)
MKXMohawk homeobox. (352 aa)
DRGXDorsal root ganglia homeobox. (263 aa)
HHEXHematopoietically expressed homeobox. (270 aa)
PITX3Homeobox protein. (302 aa)
EMX2Empty spiracles homeobox 2. (252 aa)
NKX6-2NKX6-2 isoform 1. (276 aa)
VENTXVENTX isoform 1. (258 aa)
POU2F3POU domain protein. (436 aa)
BSXBrain specific homeobox. (233 aa)
BARX2BARX homeobox 2. (279 aa)
NANOGHomeobox protein NANOG; Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT] [...] (305 aa)
DBX2Developing brain homeobox 2. (339 aa)
HOXC13HOXC13 isoform 1. (330 aa)
HOXC12HOXC12 isoform 1. (280 aa)
HOXC11HOXC11 isoform 1. (304 aa)
HOXC9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (260 aa)
HOXC8HOXC8 isoform 1. (242 aa)
HOXC6HOXC6 isoform 1. (235 aa)
ALX1ALX homeobox 1. (326 aa)
LHX5LHX5 isoform 2. (402 aa)
GSX1GSX1 isoform 1. (264 aa)
PDX1Pancreas/duodenum homeobox protein 1; Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element [...] (283 aa)
NKX2-8NKX2-8 isoform 1. (239 aa)
OTX2Orthodenticle homeobox 2. (297 aa)
VSX2VSX2 isoform 1. (380 aa)
GSCHomeobox protein goosecoid; Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring (By similarity). Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm cell lineages in mammals (By similarity); Belongs to the paired homeobox family. Bicoid subfamily. (257 aa)
ISL2ISL LIM homeobox 2. (359 aa)
IRX3Iroquois homeobox 3. (500 aa)
IRX6Iroquois homeobox 6. (445 aa)
ZFHX3Zinc finger homeobox 3. (3688 aa)
MEOX1Homeobox protein MOX-1; Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints. Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independen [...] (254 aa)
HOXB1Homeobox protein Hox-B1; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures (By similarity); Belongs to the Antp homeobox family. Labial subfamily. (301 aa)
HOXB2HOXB2 isoform 1. (356 aa)
HOXB4HOXB4 isoform 1. (251 aa)
HOXB5HOXB5 isoform 1. (269 aa)
HOXB6HOXB6 isoform 1. (224 aa)
HOXB7HOXB7 isoform 2. (217 aa)
HOXB13HOXB13 isoform 1. (284 aa)
DLX4Distal-less homeobox 4. (240 aa)
DLX3Distal-less homeobox 3. (287 aa)
RAXRetina and anterior neural fold homeobox. (346 aa)
RAX2Retina and anterior neural fold homeobox protein 2; May be involved in modulating the expression of photoreceptor specific genes. Binds to the Ret-1 and Bat-1 element within the rhodopsin promoter (By similarity). (184 aa)
CRXCone-rod homeobox. (299 aa)
SIX2SIX homeobox 2. (291 aa)
OTX1Orthodenticle homeobox 1. (354 aa)
VAX2Ventral anterior homeobox 2. (290 aa)
TLX2T-cell leukemia homeobox 2. (284 aa)
DLX2Distal-less homeobox 2. (328 aa)
EVX2Even-skipped homeobox 2. (476 aa)
HOXD13HOXD13 isoform 1. (344 aa)
HOXD10Homeobox protein Hox-D10; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. (410 aa)
GBX2Gastrulation brain homeobox 2. (348 aa)
NKX2-4NKX2-4 isoform 1. (354 aa)
NKX2-2NKX2-2 isoform 1. (273 aa)
ISXIntestine specific homeobox. (245 aa)
HESX1Homeobox expressed in ES cells 1; Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation (By similarity). (185 aa)
POU1F1POU domain protein. (317 aa)
ARGFXArginine-fifty homeobox. (315 aa)
PHOX2BPaired like homeobox 2B. (314 aa)
GSX2GSX2 isoform 2. (304 aa)
NKX6-1NKX6-1 isoform 2. (367 aa)
PITX2Homeobox protein. (324 aa)
POU4F2POU domain protein. (406 aa)
IRX2Iroquois homeobox 2. (471 aa)
IRX1Iroquois homeobox 1. (480 aa)
ISL1ISL LIM homeobox 1. (349 aa)
OTPOrthopedia homeobox. (325 aa)
PITX1Homeobox protein. (314 aa)
CDX1CDX1 isoform 1. (265 aa)
TLX3TLX3 isoform 1. (291 aa)
NKX2-5NKX2-5 isoform 1. (325 aa)
MSX2Homeobox protein MSX-2; Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter (By similarity); Belongs to the Msh homeobox family. (267 aa)
PROP1PROP paired-like homeobox 1. (226 aa)
POU5F1POU domain, class 5, transcription factor 1; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency (By similarity). (360 aa)
PBX2Pre-B-cell leukemia homeobox 2. (430 aa)
MEOX2Mesenchyme homeobox 2. (302 aa)
HOXA1HOXA1 isoform 2. (335 aa)
HOXA2HOXA2 isoform 1. (376 aa)
HOXA5HOXA5 isoform 1. (270 aa)
HOXA7Homeobox protein Hox-A7; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. (230 aa)
HOXA11HOXA11 isoform 2. (313 aa)
EVX1EVX1 isoform 2. (407 aa)
DLX5Distal-less homeobox 5. (289 aa)
PAX4PAX4 isoform 1. (351 aa)
GBX1Gastrulation brain homeobox 1. (363 aa)
NKX2-6NKX2-6 isoform 1. (301 aa)
LHX2LHX2 isoform 1. (406 aa)
LMX1BLIM homeobox transcription factor 1 beta. (402 aa)
PRRX2Paired related homeobox 2. (253 aa)
BARHL1BarH like homeobox 1. (327 aa)
CDX4Caudal type homeobox 4. (284 aa)
DLX1Distal-less homeobox 1. (255 aa)
ZFHX4Zinc finger homeobox 4. (3615 aa)
HOXA4HOXA4 isoform 1. (320 aa)
SIX4SIX homeobox 4. (781 aa)
HOXB9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (250 aa)
DMBX1Diencephalon/mesencephalon homeobox 1. (377 aa)
BARX1BARX homeobox 1. (254 aa)
MNX1Motor neuron and pancreas homeobox 1. (398 aa)
PHOX2APaired like homeobox 2A. (284 aa)
HOXA13-2HOXA13 isoform 1. (388 aa)
CK820_G0042272TPRX1 isoform 2. (510 aa)
SIX5SIX homeobox 5. (738 aa)
EN1Homeobox protein engrailed-like. (396 aa)
LBX1Ladybird homeobox 1. (281 aa)
POU3F1POU domain protein. (451 aa)
ZFHX2ZFHX2 isoform 1. (2572 aa)
NKX6-3NKX6-3 isoform 1. (265 aa)
LHX1LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis (By similarity). (406 aa)
HOXD8Homeobox protein Hox-D8; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. (289 aa)
MSX1Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). (303 aa)
HOXD11HOXD11 isoform 2. (339 aa)
EMX1Empty spiracles homeobox 1. (290 aa)
DLX6DLX6 isoform 1. (295 aa)
HOXA6HOXA6 isoform 2. (233 aa)
HOXD12HOXD12 isoform 1. (270 aa)
POU3F4POU domain protein. (361 aa)
NKX1-1NKX1-1 isoform 1. (408 aa)
ANHXAnomalous homeobox. (379 aa)
DUXBDouble homeobox B. (345 aa)
PBX1Pre-B-cell leukemia homeobox 1. (486 aa)
NKX1-2NKX1-2 isoform 1. (310 aa)
HOXB3HOXB3 isoform 13. (431 aa)
LHX3LHX3 isoform 2. (402 aa)
UNCXUNCX isoform 1. (531 aa)
GSC2Goosecoid homeobox 2. (205 aa)
PAX6PAX6 isoform 13. (436 aa)
RHOXF1RHOXF1 isoform 1. (184 aa)
HOXA10HOXA10 isoform 2. (410 aa)
HMX1H6 family homeobox 1. (348 aa)
IRX5Iroquois homeobox 5. (483 aa)
HOXA3HOXA3 isoform 3. (443 aa)
DBX1Developing brain homeobox 1. (345 aa)
NKX3-2NKX3-2 isoform 1. (333 aa)
SHOXShort stature homeobox. (292 aa)
SIX1SIX homeobox 1. (284 aa)
CDX2Caudal type homeobox 2. (313 aa)
ARXARX isoform 1. (559 aa)
MIXL1Mix paired-like homeobox. (232 aa)
HOXC5HOXC5 isoform 1. (222 aa)
TLX1T cell leukemia homeobox 1. (330 aa)
LHX8LHX8 isoform 2. (377 aa)
NKX2-1NKX2-1 isoform 1. (401 aa)
EN2-2Homeobox protein engrailed-like. (336 aa)
IRX4IRX4 isoform 3. (543 aa)
HOXC4HOXC4 isoform 1. (264 aa)
NKX2-3NKX2-3 isoform 1. (366 aa)
POU3F3POU domain protein. (476 aa)
POU2F1POU domain protein. (766 aa)
HMX3H6 family homeobox 3. (357 aa)
LHX9LHX9 isoform 2. (397 aa)
HOXD9HOXD9 isoform 1. (356 aa)
POU2F2POU domain protein. (622 aa)
NKX3-1NKX3-1 isoform 1. (234 aa)
ALX4ALX homeobox 4. (411 aa)
HMX2H6 family homeobox 2. (273 aa)
VSX1Visual system homeobox 1. (365 aa)
LEUTXLEUTX isoform 2. (198 aa)
LHX6LHX6 isoform 3. (428 aa)
HOXD3HOXD3 isoform 3. (432 aa)
VAX1Ventral anterior homeobox 1. (334 aa)
HOXD4Homeobox protein Hox-D4; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. Deformed subfamily. (255 aa)
HOXB8HOXB8 isoform 1. (243 aa)
CUX2Homeobox protein cut-like. (1489 aa)
HOXD1HOXD1 isoform 1. (328 aa)
POU5F1BPOU domain protein. (359 aa)
CUX1Homeobox protein cut-like. (1515 aa)
PAX3PAX3 isoform 4. (505 aa)
SHOX2SHOX2 isoform 2. (343 aa)
ESX1ESX homeobox 1. (431 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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