STRINGSTRING
CASP10 CASP10 CASP3 CASP3 CASP12 CASP12 CASP5 CASP5 CASP4 CASP4 CASP2 CASP2 CASP8 CASP8 CASP6 CASP6 CASP1 CASP1 CASP7 CASP7 CASP14 CASP14 CASP9 CASP9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CASP10CASP10 isoform 4; Belongs to the peptidase C14A family. (523 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (277 aa)
CASP12CASP12 isoform 1; Belongs to the peptidase C14A family. (341 aa)
CASP5CASP5 isoform 3; Belongs to the peptidase C14A family. (448 aa)
CASP4Caspase 4, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (377 aa)
CASP2Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (452 aa)
CASP8Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (538 aa)
CASP6Caspase 6, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (293 aa)
CASP1CASP1 isoform 4; Belongs to the peptidase C14A family. (404 aa)
CASP7CASP7 isoform 1; Belongs to the peptidase C14A family. (388 aa)
CASP14CASP14 isoform 1; Belongs to the peptidase C14A family. (242 aa)
CASP9CASP9 isoform 4; Belongs to the peptidase C14A family. (421 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.