STRINGSTRING
HEY2 HEY2 BHLHA9 BHLHA9 SREBF2 SREBF2 BHLHE23 BHLHE23 NCOA3 NCOA3 FIGLA FIGLA MXD1 MXD1 EPAS1 EPAS1 TCF23 TCF23 NCOA1 NCOA1 MSGN1 MSGN1 ID2 ID2 NPAS1 NPAS1 MLX MLX MNT MNT MESP2 MESP2 MESP1 MESP1 TCF12 TCF12 MGA MGA HIF1A HIF1A SOHLH2 SOHLH2 MLXIP MLXIP ASCL4 ASCL4 MYF5 MYF5 MYF6 MYF6 BHLHE41 BHLHE41 MYOD1 MYOD1 ASCL3 ASCL3 ATOH7 ATOH7 USF1 USF1 MYCL MYCL ID3 ID3 HES2 HES2 CLOCK CLOCK NEUROG1 NEUROG1 HAND1 HAND1 TCF21 TCF21 OLIG3 OLIG3 AHR AHR FERD3L FERD3L NEUROD6 NEUROD6 MLXIPL MLXIPL BHLHA15 BHLHA15 HES3 HES3 STRA8 STRA8 TAL2 TAL2 SOHLH1 SOHLH1 TFE3 TFE3 MSC MSC HES5 HES5 TCF4 TCF4 MYOG MYOG ARNT ARNT MXD4 MXD4 HES4 HES4 TWIST1 TWIST1 HAND2 HAND2 USF3 USF3 BHLHE40 BHLHE40 TCF15 TCF15 ATOH1 ATOH1 ID1 ID1 MYCN MYCN NEUROG3 NEUROG3 BHMG1 BHMG1 NEUROD4 NEUROD4 TFAP4 TFAP4 TAL1 TAL1 HES1 HES1 ARNTL ARNTL ATOH8 ATOH8 TCF3 TCF3 HEY1 HEY1 OLIG2 OLIG2 NPAS2 NPAS2 NCOA2 NCOA2 ID4 ID4 SCX SCX ARNT2 ARNT2 TFEB TFEB LYL1 LYL1 HELT HELT NPAS3 NPAS3 MXD3 MXD3 MYC MYC HES6 HES6 SREBF1 SREBF1 HES7 HES7 ASCL1 ASCL1 USF2 USF2 ASCL5 ASCL5 OLIG1-2 OLIG1-2 ARNTL2 ARNTL2 ASCL2 ASCL2 NHLH1 NHLH1 SIM1 SIM1 PTF1A PTF1A NHLH2 NHLH2 NEUROG2 NEUROG2 MITF MITF CK820_G0007197 CK820_G0007197 MAX MAX TFEC TFEC HEYL HEYL NEUROD2 NEUROD2 SIM2 SIM2 MXI1 MXI1 TCF24 TCF24 HIF3A HIF3A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HEY2Hairy/enhancer-of-split related with YRPW motif 2. (337 aa)
BHLHA9Basic helix-loop-helix family member a9. (235 aa)
SREBF2Sterol regulatory element binding transcription factor 2. (1142 aa)
BHLHE23Basic helix-loop-helix family member e23. (241 aa)
NCOA3Nuclear receptor coactivator. (1426 aa)
FIGLAFolliculogenesis specific bHLH transcription factor. (219 aa)
MXD1MAX dimerization protein 1. (221 aa)
EPAS1Endothelial PAS domain protein 1. (870 aa)
TCF23Transcription factor 23. (214 aa)
NCOA1Nuclear receptor coactivator. (1441 aa)
MSGN1MSGN1 isoform 1. (193 aa)
ID2Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein. (134 aa)
NPAS1Neuronal PAS domain protein 1. (590 aa)
MLXMAX dimerization protein MLX. (298 aa)
MNTMAX binding protein. (582 aa)
MESP2Mesoderm posterior bHLH transcription factor 2. (389 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (268 aa)
TCF12Transcription factor 12. (706 aa)
MGAMAX dimerization protein MGA. (3068 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
SOHLH2CCDC169-SOHLH2 isoform 1. (424 aa)
MLXIPMLX interacting protein. (919 aa)
ASCL4Achaete-scute family bHLH transcription factor 4. (173 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
MYF6Myogenic factor 6. (242 aa)
BHLHE41Basic helix-loop-helix family member e41. (482 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (320 aa)
ASCL3Achaete-scute family bHLH transcription factor 3. (181 aa)
ATOH7Atonal bHLH transcription factor 7. (152 aa)
USF1Upstream transcription factor 1. (310 aa)
MYCLMYCL isoform 2. (394 aa)
ID3Inhibitor of DNA binding 3, dominant negative helix-loop-helix protein. (119 aa)
HES2Hes family bHLH transcription factor 2. (173 aa)
CLOCKClock circadian regulator. (847 aa)
NEUROG1NEUROG1 isoform 1. (237 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
TCF21Transcription factor 21. (179 aa)
OLIG3Oligodendrocyte transcription factor 3. (272 aa)
AHRT0073207 isoform 1. (850 aa)
FERD3LFer3 like bHLH transcription factor. (166 aa)
NEUROD6Neurogenic differentiation factor. (337 aa)
MLXIPLMLX interacting protein like. (852 aa)
BHLHA15Basic helix-loop-helix family member a15. (189 aa)
HES3HES3 isoform 1. (185 aa)
STRA8Stimulated by retinoic acid 8. (330 aa)
TAL2TAL bHLH transcription factor 2. (108 aa)
SOHLH1Spermatogenesis and oogenesis specific basic helix-loop-helix 1. (387 aa)
TFE3Transcription factor binding to IGHM enhancer 3. (406 aa)
MSCMSC isoform 1. (295 aa)
HES5Hes family bHLH transcription factor 5. (165 aa)
TCF4Transcription factor 4. (773 aa)
MYOGMYOG isoform 1. (249 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (789 aa)
MXD4MAX dimerization protein 4. (209 aa)
HES4Hes family bHLH transcription factor 4. (221 aa)
TWIST1TWIST1 isoform 2. (163 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
USF3USF3 isoform 1. (2240 aa)
BHLHE40Basic helix-loop-helix family, member e40. (412 aa)
TCF15Transcription factor 15. (197 aa)
ATOH1Protein atonal homolog 1; Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity). (356 aa)
ID1Inhibitor of DNA binding 1, dominant negative helix-loop-helix protein. (155 aa)
MYCNMYCN isoform 2. (464 aa)
NEUROG3NEUROG3 isoform 1. (214 aa)
BHMG1BHMG1 isoform 1. (638 aa)
NEUROD4Neurogenic differentiation factor. (331 aa)
TFAP4Transcription factor AP-4 (Activating enhancer binding protein 4). (338 aa)
TAL1TAL bHLH transcription factor 1, erythroid differentiation factor. (331 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator-like. (628 aa)
ATOH8Atonal bHLH transcription factor 8. (323 aa)
TCF3TCF3 isoform 3. (673 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
OLIG2OLIG2 isoform 1. (323 aa)
NPAS2Neuronal PAS domain protein 2. (827 aa)
NCOA2Nuclear receptor coactivator. (1464 aa)
ID4Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein. (161 aa)
SCXScleraxis bHLH transcription factor. (201 aa)
ARNT2ARNT2 isoform 2. (759 aa)
TFEBTranscription factor EB. (490 aa)
LYL1LYL1 basic helix-loop-helix family member. (280 aa)
HELTHELT isoform 3. (327 aa)
NPAS3NPAS3 isoform 1. (937 aa)
MXD3MXD3 isoform 5. (387 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (454 aa)
HES6Hes family bHLH transcription factor 6. (224 aa)
SREBF1SREBF1 isoform 6. (1177 aa)
HES7Hes family bHLH transcription factor 7. (259 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (232 aa)
USF2Upstream transcription factor 2, c-fos interacting. (336 aa)
ASCL5Achaete-scute family bHLH transcription factor 5. (206 aa)
OLIG1-2OLIG1 isoform 1. (272 aa)
ARNTL2Aryl hydrocarbon receptor nuclear translocator like 2. (635 aa)
ASCL2Achaete-scute family bHLH transcription factor 2. (193 aa)
NHLH1Nescient helix-loop-helix 1. (133 aa)
SIM1Single-minded homolog 1; Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult. (767 aa)
PTF1APancreas associated transcription factor 1a. (328 aa)
NHLH2Nescient helix-loop-helix 2. (135 aa)
NEUROG2NEUROG2 isoform 1. (272 aa)
MITFMITF isoform 1. (519 aa)
CK820_G0007197TFEB isoform 4. (550 aa)
MAXMYC associated factor X. (162 aa)
TFECTranscription factor EC; Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter. Collaborates with MITF in target gene activation. Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence. Binds to mu E3 DNA sequence of the imm [...] (347 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
NEUROD2Neurogenic differentiation factor. (382 aa)
SIM2SIM bHLH transcription factor 2. (667 aa)
MXI1MAX interactor 1, dimerization protein. (295 aa)
TCF24Transcription factor 24. (167 aa)
HIF3AHypoxia inducible factor 3 subunit alpha. (669 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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