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SUPT6H SUPT6H SOCS1 SOCS1 FES FES SH2D7 SH2D7 CSK CSK SHC4 SHC4 SHF SHF SH2B3 SH2B3 SOCS2 SOCS2 STAT6 STAT6 CBL CBL INPPL1 INPPL1 BLNK BLNK SHE SHE BLK BLK RIN1 RIN1 SH2D1A SH2D1A CRKL CRKL LYN LYN SH2D1B SH2D1B CHN2 CHN2 MATK MATK TNS3 TNS3 JAK3 JAK3 JAK1 JAK1 LCK LCK FGR FGR SH2D3C SH2D3C SH2D4A SH2D4A FRK FRK LCP2 LCP2 ITK ITK FER FER RASA1 RASA1 DAPP1 DAPP1 STAP1 STAP1 CLNK CLNK NCK1 NCK1 CBLB CBLB GRAP2 GRAP2 SRMS SRMS PLCG1 PLCG1 SLA2 SLA2 HCK HCK INPP5D INPP5D TNS4 TNS4 YES1 YES1 VAV2 VAV2 CRK CRK BCAR3 BCAR3 CISH CISH JAK2 JAK2 STAT4 STAT4 FYN FYN PIK3R1 PIK3R1 SRC SRC PLCG2 PLCG2 GRAPL GRAPL STAP2 STAP2 SYK SYK CK820_G0050194 CK820_G0050194 SH2B2 SH2B2 ABL1 ABL1 STAT1 STAT1 STAT3 STAT3 STAT2 STAT2 CBLC CBLC TXK TXK SH3BP2 SH3BP2 STAT5B STAT5B TEC TEC GRB7 GRB7 RIN2 RIN2 PIK3R3 PIK3R3 SHC3 SHC3 TNS2 TNS2 SLA SLA SOCS4 SOCS4 PTK6 PTK6 SOCS5 SOCS5 PTPN11 PTPN11 GRB10 GRB10 SH2D6 SH2D6 SHC1 SHC1 SH2D2A SH2D2A PTPN6 PTPN6 SHB SHB TYK2 TYK2 SH2B1 SH2B1 TNS1 TNS1 CHN1 CHN1 GRB14 GRB14 NCK2 NCK2 ZAP70 ZAP70 RINL RINL PIK3R2 PIK3R2 HSH2D HSH2D VAV1 VAV1 SH2D3A SH2D3A BMX BMX SOCS3 SOCS3 RIN3 RIN3 SOCS7 SOCS7 ABL2 ABL2 VAV3 VAV3 SHD SHD SOCS6 SOCS6 GRB2 GRB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SUPT6HTranscription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1726 aa)
SOCS1Suppressor of cytokine signaling 1. (211 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (827 aa)
SH2D7SH2 domain containing 7. (451 aa)
CSKTyrosine-protein kinase. (450 aa)
SHC4SHC adaptor protein 4. (630 aa)
SHFSrc homology 2 domain containing F. (423 aa)
SH2B3SH2B adaptor protein 3. (575 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
CBLCas-Br-M (Murine) ecotropic retroviral transforming sequence. (906 aa)
INPPL1Inositol polyphosphate phosphatase-like 1. (1258 aa)
BLNKBLNK isoform 2. (456 aa)
SHESrc homology 2 domain containing E. (495 aa)
BLKTyrosine-protein kinase. (505 aa)
RIN1Ras and Rab interactor 1. (783 aa)
SH2D1ASH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. (128 aa)
CRKLV-crk sarcoma virus CT10 oncogene homolog (Avian)-like. (303 aa)
LYNTyrosine-protein kinase. (512 aa)
SH2D1BSH2 domain containing 1B. (132 aa)
CHN2Chimaerin; GTPase-activating protein for p21-rac. (468 aa)
MATKTyrosine-protein kinase. (508 aa)
TNS3TNS3 isoform 2. (1445 aa)
JAK3Tyrosine-protein kinase. (1124 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
LCKTyrosine-protein kinase. (539 aa)
FGRTyrosine-protein kinase. (529 aa)
SH2D3CSH2 domain containing 3C. (860 aa)
SH2D4ASH2 domain containing 4A. (454 aa)
FRKTyrosine-protein kinase. (505 aa)
LCP2Lymphocyte cytosolic protein 2. (533 aa)
ITKTyrosine-protein kinase. (620 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
RASA1RAS p21 protein activator (GTPase activating protein) 1. (1047 aa)
DAPP1Dual adaptor of phosphotyrosine and 3-phosphoinositides 1. (280 aa)
STAP1Signal transducing adaptor family member 1. (295 aa)
CLNKCytokine dependent hematopoietic cell linker. (428 aa)
NCK1Cytoplasmic protein. (377 aa)
CBLBCas-Br-M (Murine) ecotropic retroviral transforming sequence b. (982 aa)
GRAP2GRB2 related adaptor protein 2. (330 aa)
SRMSTyrosine-protein kinase. (447 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
SLA2Src like adaptor 2. (261 aa)
HCKTyrosine-protein kinase. (526 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1189 aa)
TNS4TNS4 isoform 1. (715 aa)
YES1Tyrosine-protein kinase. (558 aa)
VAV2Vav guanine nucleotide exchange factor 2. (878 aa)
CRKV-crk sarcoma virus CT10 oncogene homolog (Avian). (304 aa)
BCAR3Breast cancer anti-estrogen resistance 3. (825 aa)
CISHCytokine inducible SH2 containing protein. (275 aa)
JAK2Tyrosine-protein kinase. (1143 aa)
STAT4Signal transducer and activator of transcription. (748 aa)
FYNTyrosine-protein kinase. (537 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
SRCTyrosine-protein kinase. (542 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
GRAPLGRAP isoform 4. (100 aa)
STAP2Signal transducing adaptor family member 2. (407 aa)
SYKTyrosine-protein kinase. (635 aa)
CK820_G0050194GRAP isoform 1. (153 aa)
SH2B2Uncharacterized protein. (677 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
STAT3Signal transducer and activator of transcription. (790 aa)
STAT2Signal transducer and activator of transcription. (851 aa)
CBLCCbl proto-oncogene C. (474 aa)
TXKTyrosine-protein kinase. (527 aa)
SH3BP2SH3 domain binding protein 2. (618 aa)
STAT5BSignal transducer and activator of transcription. (772 aa)
TECTyrosine-protein kinase. (631 aa)
GRB7Growth factor receptor bound protein 7. (555 aa)
RIN2Ras and Rab interactor 2. (944 aa)
PIK3R3Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa)
SHC3SHC3 isoform 2. (598 aa)
TNS2TNS2 isoform 7. (1419 aa)
SLASrc like adaptor. (316 aa)
SOCS4Suppressor of cytokine signaling 4. (440 aa)
PTK6Tyrosine-protein kinase. (451 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
GRB10Growth factor receptor-bound protein 10. (594 aa)
SH2D6SH2 domain containing 6. (143 aa)
SHC1SHC (Src homology 2 domain containing) transforming protein 1. (584 aa)
SH2D2ASH2D2A isoform 1. (361 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
SHBSrc homology 2 domain containing adaptor protein B. (509 aa)
TYK2Tyrosine-protein kinase. (1184 aa)
SH2B1SH2B adaptor protein 1. (756 aa)
TNS1TNS1 isoform 5. (1740 aa)
CHN1Chimaerin; GTPase-activating protein for p21-rac. (459 aa)
GRB14Growth factor receptor-bound protein 14. (540 aa)
NCK2Cytoplasmic protein. (380 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
RINLRas and Rab interactor like. (566 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
HSH2DHSH2D isoform 1. (352 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
SH2D3ASH2 domain containing 3A. (576 aa)
BMXTyrosine-protein kinase. (679 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
RIN3Ras and Rab interactor 3. (983 aa)
SOCS7Suppressor of cytokine signaling 7. (580 aa)
ABL2Tyrosine-protein kinase. (1182 aa)
VAV3VAV3 isoform 2. (927 aa)
SHDSrc homology 2 domain containing transforming protein D. (340 aa)
SOCS6Suppressor of cytokine signaling 6. (535 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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